Detailed information of TA system TA211999

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 4985821..4986623
• Replicon: chromosome
• Accession: NZ_CP080525
• Organism: Mesorhizobium sp. AR07

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: -
• Locus tag: BPNPMPFG_RS25115
• Protein ID: WP_258591312.1
• Coordinates: 4985821..4986348 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: -
• Locus tag: BPNPMPFG_RS25120
• Protein ID: WP_258591313.1
• Coordinates: 4986345..4986623 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BPNPMPFG_RS25095 (BPNPMPFG_004977)	4981318..4982703	-	1386	WP_258591308.1	glutamine synthetase family protein	-
BPNPMPFG_RS25100 (BPNPMPFG_004978)	4982732..4984114	-	1383	WP_258591309.1	aspartate aminotransferase family protein	-
BPNPMPFG_RS25105 (BPNPMPFG_004979)	4984271..4984723	+	453	WP_258591310.1	hypothetical protein	-
BPNPMPFG_RS25110 (BPNPMPFG_004980)	4984739..4985713	-	975	WP_258591311.1	WD40 repeat domain-containing protein	-
BPNPMPFG_RS25115 (BPNPMPFG_004981)	4985821..4986348	-	528	WP_258591312.1	GNAT family N-acetyltransferase	Toxin
BPNPMPFG_RS25120 (BPNPMPFG_004982)	4986345..4986623	-	279	WP_258591313.1	DUF1778 domain-containing protein	Antitoxin
BPNPMPFG_RS25125 (BPNPMPFG_004983)	4986712..4987767	-	1056	WP_258591314.1	GTP-binding protein	-
BPNPMPFG_RS25130 (BPNPMPFG_004984)	4987969..4988730	+	762	WP_258591315.1	intradiol ring-cleavage dioxygenase	-
BPNPMPFG_RS25135 (BPNPMPFG_004985)	4988948..4989418	+	471	WP_258591316.1	MarR family transcriptional regulator	-
BPNPMPFG_RS25140 (BPNPMPFG_004986)	4989544..4990416	-	873	WP_258591317.1	AraC family transcriptional regulator	-
BPNPMPFG_RS25145 (BPNPMPFG_004987)	4990469..4990876	+	408	WP_258596910.1	DUF2000 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (11-86)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 18880.51 Da
• Isoelectric Point: 7.8275

>T211999 WP_258591312.1 NZ_CP080525:c4986348-4985821 [Mesorhizobium sp. AR07]
VTLPSWHEEPIAKRHDRASFDCGDAQMDDFLRRFARQSHDQNAAKTFCAIDDTASERILGFYTIAPSAVAHETVPEAMTR
GLARHEVSGFKLARLATDRSVGGQGLGGQLLAAAALRCLRLAGEGGGILLIIDAKSERAARWYASYGAERLQGPDLTLVM
PLATFATSLRAKGLL

Nucleotide

• Length: 528 bp

>T211999 NZ_CP106896:c154948-154418 [Enterobacter hormaechei]
ATGGAGGGTTTAAGGATTGAGATTTTTTCAGAGGAAGTTGAATATGAATTAAGCAACTTCGATTGTGGAGAAGAGTATCT
GAATACTTTTCTTACTGACCATCTGAAACGGCAGCATAACAGTAAGATCTTACGTGGTTATGTTCTCGTGACGAGAGAGA
ATAAACCGCGTGTGATGGGGTACTACACGCTATCAGGAAGTTGCTTTGAGAAAATACTTCTACCCAGCAAAACACAACAA
AAGCGTGTACCCTACAAGAATGTGCCGAGCGTGACTTTGGGCCGTCTGGCAATTGATAAAAGCATTCACCACCAGGGATA
TGGAGAAACACTTGTTACCCATGCGATGAAAGTCGTGTATCAGGCCTCGCAGGCTGTGGGTATACACGGAATGTTCGTGG
AAGCGCTGAACGACAACGCCAAAAAATTCTACCTTCGACTGGGTTTCATTCAGTTAAAGGAAGAAAACTGTAACTCGCTC
TTTTACCCGACAAAATCTATTGAAGAATTGTTCGAAGTAAATGATGAATAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10180.81 Da
• Isoelectric Point: 7.2046

>AT211999 WP_258591313.1 NZ_CP080525:c4986623-4986345 [Mesorhizobium sp. AR07]
VPRSADNKTERFQIRIPPVQKAMIARAAALSHKDMADFILDKIVPEAQAVIEAAEVTKVSDRDFTRILDLLEHPPKPNAR
LQAAITALPDTL

Nucleotide

• Length: 279 bp

>AT211999 NZ_CP106896:c155221-154952 [Enterobacter hormaechei]
ATGTCAGCACTGAAAAAGCAGCGCATTGACCTGAGATTAAATGAAGACGACAAACACATGATCGAAGAAGCTGCAGCAAT
GACTAACCAGTCAATTTCGCAGTTCATGGTCAGTACCGCCTCAGAACGCGCTGCAGAAGTTATTGACCAGCACCGTCGTC
TGCTCCTCAATGAGGAGTCTTGGAACCTGGTTATGGATGCAATCATTAATCCGCCAGCACCGAATGACCGGCTGAAACGC
GCCGCTAACCGTCTCCGGGAACTGGAGTAA