Detailed information of TA system TA211998

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-Phd
• Location: 4836308..4837011
• Replicon: chromosome
• Accession: NZ_CP080525
• Organism: Mesorhizobium sp. AR07

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: BPNPMPFG_RS24385
• Protein ID: WP_258591183.1
• Coordinates: 4836308..4836730 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: BPNPMPFG_RS24390
• Protein ID: WP_258591184.1
• Coordinates: 4836727..4837011 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BPNPMPFG_RS24365 (BPNPMPFG_004832)	4831717..4832352	+	636	WP_258591182.1	LysE family translocator	-
BPNPMPFG_RS24370 (BPNPMPFG_004833)	4832408..4833514	-	1107	WP_258590727.1	ISAs1 family transposase	-
BPNPMPFG_RS24375 (BPNPMPFG_004834)	4833793..4834893	+	1101	WP_258590528.1	ISAs1 family transposase	-
BPNPMPFG_RS24380 (BPNPMPFG_004835)	4834961..4835986	-	1026	WP_258596900.1	3-deoxy-7-phosphoheptulonate synthase	-
BPNPMPFG_RS24385 (BPNPMPFG_004836)	4836308..4836730	-	423	WP_258591183.1	type II toxin-antitoxin system VapC family toxin	Toxin
BPNPMPFG_RS24390 (BPNPMPFG_004837)	4836727..4837011	-	285	WP_258591184.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
BPNPMPFG_RS24395 (BPNPMPFG_004838)	4837179..4837973	-	795	WP_258591185.1	SDR family oxidoreductase	-
BPNPMPFG_RS24400 (BPNPMPFG_004839)	4837997..4838992	-	996	WP_258591186.1	inositol 2-dehydrogenase	-
BPNPMPFG_RS24405 (BPNPMPFG_004840)	4839105..4839872	-	768	WP_258591187.1	ATP-binding cassette domain-containing protein	-
BPNPMPFG_RS24410 (BPNPMPFG_004841)	4839875..4840951	-	1077	WP_258591188.1	ABC transporter permease	-
BPNPMPFG_RS24415 (BPNPMPFG_004842)	4841061..4842002	-	942	WP_258591189.1	sugar ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-125)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (17-76)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 15663.93 Da
• Isoelectric Point: 4.5883

>T211998 WP_258591183.1 NZ_CP080525:c4836730-4836308 [Mesorhizobium sp. AR07]
VRLLLDTNVLSEVTRPAPDARVLDWLDGLDEDRSFISVVSIAEIRRGVALMDEGRKREALAEWLARDLPQRFEQRVLPVD
EPVAFAWGDLMGLAKRRGRGLSSMDGLIAATAIAQELTLATRNKKDFEGFGIELFDPWTA

Nucleotide

• Length: 423 bp

>T211998 NZ_CP106896:69513-69929 [Enterobacter hormaechei]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10415.89 Da
• Isoelectric Point: 6.3680

>AT211998 WP_258591184.1 NZ_CP080525:c4837011-4836727 [Mesorhizobium sp. AR07]
MVMEVAMLSAPKEGTNWTVAGAKARLSEVIERAQSSPQTITRNGKPSVVVVSAEEWQRKTARKGTLAEFLLESPLRGADL
DLERQRDEPRDLPL

Nucleotide

• Length: 285 bp

>AT211998 NZ_CP106896:69286-69516 [Enterobacter hormaechei]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA