Detailed information of TA system TA211996

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 2505601..2506217
• Replicon: chromosome
• Accession: NZ_CP080525
• Organism: Mesorhizobium sp. AR07

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: BPNPMPFG_RS12895
• Protein ID: WP_258595754.1
• Coordinates: 2505828..2506217 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: BPNPMPFG_RS12890
• Protein ID: WP_258595753.1
• Coordinates: 2505601..2505831 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BPNPMPFG_RS12870 (BPNPMPFG_002550)	2501141..2503348	+	2208	WP_258595749.1	OmpA family protein	-
BPNPMPFG_RS12875 (BPNPMPFG_002551)	2503743..2504177	+	435	WP_258595750.1	YqhA family protein	-
BPNPMPFG_RS12880 (BPNPMPFG_002552)	2504248..2504484	+	237	WP_258595751.1	type II toxin-antitoxin system ParD family antitoxin	-
BPNPMPFG_RS12885 (BPNPMPFG_002553)	2504520..2505386	-	867	WP_258595752.1	NAD(P)-dependent oxidoreductase	-
BPNPMPFG_RS12890 (BPNPMPFG_002554)	2505601..2505831	+	231	WP_258595753.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
BPNPMPFG_RS12895 (BPNPMPFG_002555)	2505828..2506217	+	390	WP_258595754.1	type II toxin-antitoxin system VapC family toxin	Toxin
BPNPMPFG_RS12900 (BPNPMPFG_002556)	2506218..2506910	-	693	WP_258595756.1	helix-turn-helix transcriptional regulator	-
BPNPMPFG_RS12905 (BPNPMPFG_002557)	2506919..2507791	-	873	WP_258595758.1	S1C family serine protease	-
BPNPMPFG_RS12910 (BPNPMPFG_002558)	2508017..2508964	+	948	WP_258595759.1	trypsin-like peptidase domain-containing protein	-
BPNPMPFG_RS12915 (BPNPMPFG_002559)	2509102..2509323	-	222	WP_258595760.1	hypothetical protein	-
BPNPMPFG_RS12920 (BPNPMPFG_002560)	2509490..2509915	-	426	WP_258595761.1	VOC family protein	-
BPNPMPFG_RS12925 (BPNPMPFG_002561)	2509982..2510608	+	627	WP_258595762.1	TetR/AcrR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-123)

Antitoxin

• Antitoxin VapB-like (1-74)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14200.46 Da
• Isoelectric Point: 6.4650

>T211996 WP_258595754.1 NZ_CP080525:2505828-2506217 [Mesorhizobium sp. AR07]
MIIDSSVLVAILRIEPGYERFVLAIAQAKRRLLAAPTFLETTMVLAGGRQDDILDRLDSFLRSSSIETIAFTADHAAVAR
QAFLRYGKGRHPAALNFGDCIAYATARLEAMPLLFKGDDFRLTDIEAAI

Nucleotide

• Length: 390 bp

>T211996 NZ_CP106896:32513-32998 [Enterobacter hormaechei]
GTGGGACATGTAACAGCACCAGAACCTCTGTCCGCTTTTCATCAGGTGGCTGAGTTCGTGAGCGGTGAAACTGTGCTCGA
TGACTGGTTAAAGCAGAAAGGCCTAAAAAACCAGGCTCTCGGAGCGGCCAGAACGTTTGTGGTATGTAAGAAAGATACGA
AGCAAATAGCCGGCTTTTACTCTCTGGCCACCGGGAGCGTCAATCATACTGAAGCGACAGGGAATCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGCCTTGCTGTCGATCTCTCATTGCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCGCTCACAG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCCGCGGACATTGTTCCTCAGACTTCCT
CAATAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8789.97 Da
• Isoelectric Point: 5.2072

>AT211996 WP_258595753.1 NZ_CP080525:2505601-2505831 [Mesorhizobium sp. AR07]
MARELARRRRVSVTEAIRQSLEREVARERLVPRDETDDLFQRLMAIADSAGKVPKRENAMTDDEILGYDEFGIPTK

Nucleotide

• Length: 231 bp

>AT211996 NZ_CP106896:32259-32525 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATAGATGCGGCTGCGGAAATCCTCCA
CAAGTCACGTACAGATTTCATTCTTGAAATGGCCTGTCAGGCTGCCGAGAATGTGATACTCGATCGCCGGGTATTTAACT
TTAACGATGAGCAATATGCGGAGTTCATCGATATGCTTGATGCACCGGTCGCAGATGATCCCATTATCGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACATGTAA