Detailed information of TA system TA211993

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 6113901..6114535
• Replicon: chromosome
• Accession: NZ_CP080524
• Organism: Mesorhizobium sp. AR10

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LHFGNBLO_RS33315
• Protein ID: WP_258604401.1
• Coordinates: 6113901..6114293 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LHFGNBLO_RS33320
• Protein ID: WP_258604403.1
• Coordinates: 6114293..6114535 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LHFGNBLO_RS33295 (LHFGNBLO_005917)	6109364..6110536	-	1173	WP_258604397.1	glycosyltransferase family 4 protein	-
LHFGNBLO_RS33300 (LHFGNBLO_005918)	6110709..6111707	+	999	WP_258604398.1	glycosyltransferase	-
LHFGNBLO_RS33305 (LHFGNBLO_005919)	6111676..6112995	+	1320	WP_258604399.1	O-antigen ligase	-
LHFGNBLO_RS33310 (LHFGNBLO_005920)	6113071..6113886	+	816	WP_258604400.1	pyrroline-5-carboxylate reductase	-
LHFGNBLO_RS33315 (LHFGNBLO_005921)	6113901..6114293	-	393	WP_258604401.1	type II toxin-antitoxin system VapC family toxin	Toxin
LHFGNBLO_RS33320 (LHFGNBLO_005922)	6114293..6114535	-	243	WP_258604403.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
LHFGNBLO_RS33325 (LHFGNBLO_005923)	6114659..6115975	-	1317	WP_258604405.1	NAD(P)H-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-128)

Antitoxin

• Antitoxin VapB-like (1-78)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 13838.76 Da
• Isoelectric Point: 4.3596

>T211993 WP_258604401.1 NZ_CP080524:c6114293-6113901 [Mesorhizobium sp. AR10]
MFVDTSVVVAILSGEEDAGDWSNRIEAAPRRITSALVVLEAAMRLSTMLAVEPPVAEAAIEAFLREAEIEIVPIDAGDAK
LAIQAFSDYGKGRGHPAQLNLADCLSYACAKGRGFALLYKGNDFSHTDLA

Nucleotide

• Length: 393 bp

>T211993 NZ_CP106894:c3823461-3823051 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTGGTGTTTGATAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGACAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGGGATCTGCGCCGGCTAATCGTGCAACAGCCGA
CGCAGGAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8924.24 Da
• Isoelectric Point: 8.8062

>AT211993 WP_258604403.1 NZ_CP080524:c6114535-6114293 [Mesorhizobium sp. AR10]
MNLQIRDPRARALARELAAKRKISMTEAVIEALESELKRESGRVPLAERLAVIANEFKARAGEGGRAVNKDEIDDMWGHP

Nucleotide

• Length: 243 bp

>AT211993 NZ_CP106894:c3823708-3823442 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA