Detailed information of TA system TA211991

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 5367071..5367687
• Replicon: chromosome
• Accession: NZ_CP080524
• Organism: Mesorhizobium sp. AR10

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LHFGNBLO_RS29880
• Protein ID: WP_258603171.1
• Coordinates: 5367436..5367687 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LHFGNBLO_RS29875
• Protein ID: WP_258603170.1
• Coordinates: 5367071..5367439 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LHFGNBLO_RS29855 (LHFGNBLO_005232)	5363254..5364681	+	1428	WP_258603158.1	HlyD family type I secretion periplasmic adaptor subunit	-
LHFGNBLO_RS29860 (LHFGNBLO_005233)	5364968..5365249	+	282	WP_258603164.1	acylphosphatase	-
LHFGNBLO_RS29865 (LHFGNBLO_005234)	5365298..5365942	+	645	WP_258603167.1	TetR/AcrR family transcriptional regulator	-
LHFGNBLO_RS29870 (LHFGNBLO_005235)	5365911..5367074	+	1164	WP_258603168.1	isovaleryl-CoA dehydrogenase	-
LHFGNBLO_RS29875 (LHFGNBLO_005236)	5367071..5367439	-	369	WP_258603170.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LHFGNBLO_RS29880 (LHFGNBLO_005237)	5367436..5367687	-	252	WP_258603171.1	type II toxin-antitoxin system HicA family toxin	Toxin
LHFGNBLO_RS29885 (LHFGNBLO_005238)	5367807..5369414	+	1608	WP_258603173.1	carboxyl transferase domain-containing protein	-
LHFGNBLO_RS29890 (LHFGNBLO_005239)	5369416..5369946	+	531	WP_258603181.1	O-acetyl-ADP-ribose deacetylase	-
LHFGNBLO_RS29895 (LHFGNBLO_005240)	5370067..5370444	+	378	WP_258609960.1	hypothetical protein	-
LHFGNBLO_RS29900 (LHFGNBLO_005241)	5370511..5372472	+	1962	WP_258603183.1	acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (22-76)

Antitoxin

• Uncharacterised protein family HicB (52-102)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9217.66 Da
• Isoelectric Point: 11.4362

>T211991 WP_258603171.1 NZ_CP080524:c5367687-5367436 [Mesorhizobium sp. AR10]
MRGKHKQTLDAISNPVSGSIKWRDVEALLVALGARVSEGRGSRVRFTLNGITLRVHRPHPSPDAKAYVIREIRTFLIDSG
VEL

Nucleotide

• Length: 252 bp

>T211991 NZ_CP106894:c2295067-2294582 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCGCCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCATTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCACTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATACTTGCCCGTCTGGCTGTTGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATTGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCCGGCTTCCT
CAGTAG

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13860.54 Da
• Isoelectric Point: 5.6040

>AT211991 WP_258603170.1 NZ_CP080524:c5367439-5367071 [Mesorhizobium sp. AR10]
MKPYKGYLGTIEFDENDVVFHGRIMGIRDIFTYEADSAEELLKAFHECVDDYLEFCAEQNKEPEKPFSGKLALRTTPEVH
HLVSRAAASDGKSINQWVSDTLAEVARKRVDEGSTKVRTRAH

Nucleotide

• Length: 369 bp

>AT211991 NZ_CP106894:c2295321-2295055 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACAGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCGCAGTGGGACGTGTAA