Detailed information of TA system TA211990

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 5263636..5264107
• Replicon: chromosome
• Accession: NZ_CP080524
• Organism: Mesorhizobium sp. AR10

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LHFGNBLO_RS29330
• Protein ID: WP_258602833.1
• Coordinates: 5263636..5263902 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: LHFGNBLO_RS29335
• Protein ID: WP_258602840.1
• Coordinates: 5263886..5264107 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LHFGNBLO_RS29305 (LHFGNBLO_005122)	5258739..5259629	-	891	WP_258602812.1	YicC/YloC family endoribonuclease	-
LHFGNBLO_RS29310 (LHFGNBLO_005123)	5259814..5261046	-	1233	WP_258602813.1	endolytic transglycosylase MltG	-
LHFGNBLO_RS29315 (LHFGNBLO_005124)	5261134..5262396	-	1263	WP_258602821.1	beta-ketoacyl-ACP synthase II	-
LHFGNBLO_RS29320 (LHFGNBLO_005125)	5262431..5262667	-	237	WP_056109445.1	acyl carrier protein	-
LHFGNBLO_RS29325 (LHFGNBLO_005126)	5262857..5263594	-	738	WP_258602830.1	3-oxoacyl-[acyl-carrier-protein] reductase	-
LHFGNBLO_RS29330 (LHFGNBLO_005127)	5263636..5263902	-	267	WP_258602833.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LHFGNBLO_RS29335 (LHFGNBLO_005128)	5263886..5264107	-	222	WP_258602840.1	ribbon-helix-helix protein, CopG family	Antitoxin
LHFGNBLO_RS29340 (LHFGNBLO_005129)	5264194..5265141	-	948	WP_258602842.1	ACP S-malonyltransferase	-
LHFGNBLO_RS29345 (LHFGNBLO_005130)	5265403..5267325	+	1923	WP_258602844.1	LTA synthase family protein	-
LHFGNBLO_RS29350 (LHFGNBLO_005131)	5267634..5268134	+	501	WP_258602846.1	30S ribosomal protein S6	-
LHFGNBLO_RS29355 (LHFGNBLO_005132)	5268134..5268382	+	249	WP_006203718.1	30S ribosomal protein S18	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-39)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10437.07 Da
• Isoelectric Point: 10.1808

>T211990 WP_258602833.1 NZ_CP080524:c5263902-5263636 [Mesorhizobium sp. AR10]
VAWTLEYARSARKFVEKLDPQTRHRIRDFIENRIAVLDNPRELGKPLKGPLATFWRYRVGDYRIICDVQDDRLVILVVTI
GHRGDVYR

Nucleotide

• Length: 267 bp

>T211990 NZ_CP106894:c1116241-1116023 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTCGAACGTGT
TATTGAAAAAAATAAATACGAGCTCTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTGGCTGAAC
TAACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTATGGAAATTTGTTCGTTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8535.59 Da
• Isoelectric Point: 4.2614

>AT211990 WP_258602840.1 NZ_CP080524:c5264107-5263886 [Mesorhizobium sp. AR10]
MPTSIRLAPEIEERLDFLANKTGRSKAYYLRELIERGLEDVEDYYLAAEVLERIRSGEEEVVKAEDFWRGLDA

Nucleotide

• Length: 222 bp

>AT211990 NZ_CP106894:c1116643-1116269 [Enterobacter hormaechei]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAACGAGCTGATCGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGCCT
ATTTCGCTGCTTCACCAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA