Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1425914..1426558 | Replicon | chromosome |
| Accession | NC_007146 | ||
| Organism | Haemophilus influenzae 86-028NP | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | Q4QKY0 |
| Locus tag | NTHI_RS07120 | Protein ID | WP_005643265.1 |
| Coordinates | 1425914..1426099 (+) | Length | 62 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | Q4QKX9 |
| Locus tag | NTHI_RS07125 | Protein ID | WP_005692602.1 |
| Coordinates | 1426130..1426558 (+) | Length | 143 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NTHI_RS07085 (NTHI1498) | 1421309..1421560 | - | 252 | WP_005688811.1 | hypothetical protein | - |
| NTHI_RS07090 (NTHI1499) | 1421679..1421990 | - | 312 | WP_005651098.1 | hypothetical protein | - |
| NTHI_RS07095 (NTHI1501) | 1422376..1422561 | - | 186 | WP_005651099.1 | hypothetical protein | - |
| NTHI_RS07100 (NTHI1502) | 1422722..1423870 | - | 1149 | WP_005651101.1 | type I restriction enzyme HsdR N-terminal domain-containing protein | - |
| NTHI_RS07105 (NTHI1503) | 1423881..1424741 | - | 861 | WP_011272498.1 | hypothetical protein | - |
| NTHI_RS07110 (NTHI1504) | 1424804..1425169 | - | 366 | WP_011272499.1 | DNA-directed RNA polymerase sigma-70 factor | - |
| NTHI_RS07115 (NTHI1505) | 1425171..1425758 | - | 588 | WP_011272500.1 | recombination protein NinG | - |
| NTHI_RS07120 (NTHI1507) | 1425914..1426099 | + | 186 | WP_005643265.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| NTHI_RS07125 (NTHI1508) | 1426130..1426558 | + | 429 | WP_005692602.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| NTHI_RS07130 (NTHI1509) | 1426559..1427068 | - | 510 | WP_005692600.1 | DUF1367 family protein | - |
| NTHI_RS07135 (NTHI1510) | 1427073..1427663 | - | 591 | WP_011272501.1 | N-6-adenine methyltransferase | - |
| NTHI_RS07140 (NTHI1511) | 1427660..1428295 | - | 636 | WP_011272502.1 | replication P | - |
| NTHI_RS07145 (NTHI1512) | 1428280..1429062 | - | 783 | WP_011272503.1 | helix-turn-helix domain-containing protein | - |
| NTHI_RS07150 (NTHI1513) | 1429064..1429297 | - | 234 | WP_005651121.1 | helix-turn-helix domain-containing protein | - |
| NTHI_RS07155 (NTHI1515) | 1429343..1429795 | - | 453 | WP_005651123.1 | hypothetical protein | - |
| NTHI_RS07160 (NTHI1516) | 1429839..1430045 | - | 207 | WP_006995067.1 | helix-turn-helix domain-containing protein | - |
| NTHI_RS07165 (NTHI1517) | 1430179..1431147 | + | 969 | WP_011272504.1 | helix-turn-helix transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1404973..1460251 | 55278 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 62 a.a. Molecular weight: 6716.88 Da Isoelectric Point: 11.1595
>T21199 WP_005643265.1 NC_007146:1425914-1426099 [Haemophilus influenzae 86-028NP]
MRSSDLIKELKSAGCTFVRHGKGDHQIWQSPITGKTFPVPHPKQHVPIGTLRSIKKSAGLL
MRSSDLIKELKSAGCTFVRHGKGDHQIWQSPITGKTFPVPHPKQHVPIGTLRSIKKSAGLL
Download Length: 186 bp
>T21199 NC_007146:1425914-1426099 [Haemophilus influenzae 86-028NP]
ATGCGATCCAGCGACTTAATCAAGGAACTTAAAAGTGCAGGTTGTACTTTTGTCAGGCACGGTAAAGGCGATCATCAAAT
CTGGCAATCGCCCATCACAGGGAAGACGTTCCCCGTACCGCATCCAAAACAACACGTACCCATCGGCACATTAAGATCCA
TCAAAAAATCGGCAGGGCTTCTATAG
ATGCGATCCAGCGACTTAATCAAGGAACTTAAAAGTGCAGGTTGTACTTTTGTCAGGCACGGTAAAGGCGATCATCAAAT
CTGGCAATCGCCCATCACAGGGAAGACGTTCCCCGTACCGCATCCAAAACAACACGTACCCATCGGCACATTAAGATCCA
TCAAAAAATCGGCAGGGCTTCTATAG
Antitoxin
Download Length: 143 a.a. Molecular weight: 16458.45 Da Isoelectric Point: 4.3241
>AT21199 WP_005692602.1 NC_007146:1426130-1426558 [Haemophilus influenzae 86-028NP]
MLFTIGIETPTNENEAYGITVPALFTEEYSCFSAADTLEEIPTQVTDAIHSILEMMFEDGIDINELQDKGYRHYQTQEDF
NYCDTWLLLDVDISAYQGKRHRINISLPEYLIKRIDSRVASNPIYKDRSHFLAIASQKELRQ
MLFTIGIETPTNENEAYGITVPALFTEEYSCFSAADTLEEIPTQVTDAIHSILEMMFEDGIDINELQDKGYRHYQTQEDF
NYCDTWLLLDVDISAYQGKRHRINISLPEYLIKRIDSRVASNPIYKDRSHFLAIASQKELRQ
Download Length: 429 bp
>AT21199 NC_007146:1426130-1426558 [Haemophilus influenzae 86-028NP]
ATGTTATTCACTATCGGCATTGAAACCCCAACAAACGAAAATGAAGCCTACGGCATTACGGTGCCAGCATTATTTACTGA
AGAATATTCCTGCTTTAGTGCCGCTGATACCCTTGAGGAAATCCCAACGCAGGTGACTGATGCCATTCATTCCATCTTAG
AAATGATGTTTGAAGACGGAATAGACATCAACGAACTTCAAGATAAAGGCTATCGTCACTACCAAACGCAAGAAGATTTC
AACTATTGCGATACTTGGTTGTTGCTTGATGTAGATATTTCCGCATATCAAGGCAAACGCCACCGTATTAATATCAGCTT
GCCTGAATACCTTATCAAACGTATTGATAGCCGTGTTGCAAGCAATCCAATCTACAAAGACCGCAGCCACTTTTTAGCGA
TTGCCTCACAAAAAGAGCTACGGCAATAA
ATGTTATTCACTATCGGCATTGAAACCCCAACAAACGAAAATGAAGCCTACGGCATTACGGTGCCAGCATTATTTACTGA
AGAATATTCCTGCTTTAGTGCCGCTGATACCCTTGAGGAAATCCCAACGCAGGTGACTGATGCCATTCATTCCATCTTAG
AAATGATGTTTGAAGACGGAATAGACATCAACGAACTTCAAGATAAAGGCTATCGTCACTACCAAACGCAAGAAGATTTC
AACTATTGCGATACTTGGTTGTTGCTTGATGTAGATATTTCCGCATATCAAGGCAAACGCCACCGTATTAATATCAGCTT
GCCTGAATACCTTATCAAACGTATTGATAGCCGTGTTGCAAGCAATCCAATCTACAAAGACCGCAGCCACTTTTTAGCGA
TTGCCTCACAAAAAGAGCTACGGCAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|