Detailed information of TA system TA211987

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 8873037..8873671
• Replicon: chromosome
• Accession: NZ_CP080521
• Organism: Pseudonocardia sp. DSM 110487

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: K1T35_RS41585
• Protein ID: WP_220257164.1
• Coordinates: 8873037..8873444 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: K1T35_RS41590
• Protein ID: WP_220257165.1
• Coordinates: 8873435..8873671 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K1T35_RS41555 (K1T35_41555)	8868786..8869205	-	420	WP_220257159.1	MerR family transcriptional regulator	-
K1T35_RS41560 (K1T35_41560)	8869234..8869986	+	753	WP_220257160.1	methyltransferase domain-containing protein	-
K1T35_RS41565 (K1T35_41565)	8869973..8871565	-	1593	WP_255621274.1	multicopper oxidase domain-containing protein	-
K1T35_RS41570 (K1T35_41570)	8871520..8871942	-	423	WP_220257161.1	hypothetical protein	-
K1T35_RS41575 (K1T35_41575)	8872042..8872374	+	333	WP_220257162.1	helix-turn-helix transcriptional regulator	-
K1T35_RS41580 (K1T35_41580)	8872371..8873069	+	699	WP_220257163.1	permease prefix domain 1-containing protein	-
K1T35_RS41585 (K1T35_41585)	8873037..8873444	-	408	WP_220257164.1	PIN domain nuclease	Toxin
K1T35_RS41590 (K1T35_41590)	8873435..8873671	-	237	WP_220257165.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
K1T35_RS41595 (K1T35_41595)	8873736..8874659	+	924	WP_220257166.1	SDR family oxidoreductase	-
K1T35_RS41600 (K1T35_41600)	8874810..8875355	+	546	WP_220257167.1	hypothetical protein	-
K1T35_RS41605 (K1T35_41605)	8875389..8876318	-	930	WP_220257168.1	ABC transporter substrate-binding protein	-
K1T35_RS41610 (K1T35_41610)	8876315..8877037	-	723	WP_220257169.1	ABC transporter permease	-
K1T35_RS41615 (K1T35_41615)	8877034..8877690	-	657	WP_220257170.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-123)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-44)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14750.18 Da
• Isoelectric Point: 10.2085

>T211987 WP_220257164.1 NZ_CP080521:c8873444-8873037 [Pseudonocardia sp. DSM 110487]
VELIDSSAWIEFFRRTGSRANVAVREMMQKRPGDVAITEPVMLELLAGAPGGRAFRQIEKLTGALQLLPVDAAVDYRDAA
MAYRAVRNGGKTVRKTMDCLIAAVAVRTGATLVHRDRDFDVLAAALPDLRVRSLV

Nucleotide

• Length: 408 bp

>T211987 NZ_CP106894:31734-32048 [Enterobacter hormaechei]
ATGCATTTAATCTCAATGAAGGCAATTTTGGATGCGGTAAGCCAGTTCCCGCAACACAGAGAAGAGCTTCTCTTTTTAGG
ACGAGTTATTGAAAAGAGCCACTGCCCGACGCCCGCTGCACTGAGAAAACTTTTCCCAACGCTGGATAACTTCAAGTATC
TTGATAAGCATTATGTTATTGATATTGCAAATAACAATCTCAGAGTAGTGGCTCTCATCTTCTTTGAAAGCCAAAAGTTT
TATGTGCGCCATGTTTTTACTCATAAGGAATATGACCGTTTTACGGAGAAACATCGCACTAAGGGGAAGAAATGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9019.24 Da
• Isoelectric Point: 4.5498

>AT211987 WP_220257165.1 NZ_CP080521:c8873671-8873435 [Pseudonocardia sp. DSM 110487]
MGRTNIDIDDELVAEAMRKYGLKTKKEAVDLALRRLVGPRLSPEFIESLEGIGWEGDLDEMRRSKIQDWAQAEVREWS

Nucleotide

• Length: 237 bp

>AT211987 NZ_CP106894:32048-32464 [Enterobacter hormaechei]
ATGATCGTCGCTGATGCAATGAAAGCTACGCACGCCCTTGTTGCGGCCGTTCCTTTACTGGGTGAACAGCCGAGCGAGAA
AGATTATAAGGATGCGCTTGAGCTGGTTGAGTATCTCCTTATGAACGAGCCCAATAGCCCCTTGCTGGATATTGTGTGCG
CCAGAATTAGCCGTTACGAAGCTAATCGGCCAGAGATAGTCGCATTACGCAAGGAGATGGAGTCCGTTCCCGTCGGAATT
GCAGTTTTAAGAACCTTGATGGATCAATACAATCTGACGATATCGGATTTTAAGGATGAAATTGGTAGTAAATCGATGGT
TTCACGGGTTCTGAATGGTCAGAGACAGCTTACCCTGAACCATATTAAAAAGCTGGCGGCCAGATTTGGGGTATCACCTG
CGTTATTTATTGAGTGA