Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 97666..98315 Replicon chromosome
Accession NZ_CP080521
Organism Pseudonocardia sp. DSM 110487

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K1T35_RS00510 Protein ID WP_220258230.1
Coordinates 97923..98315 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K1T35_RS00505 Protein ID WP_220258229.1
Coordinates 97666..97926 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1T35_RS00475 (K1T35_00475) 92692..93030 - 339 WP_220262294.1 metallopeptidase family protein -
K1T35_RS48625 93440..94057 - 618 Protein_91 septum formation family protein -
K1T35_RS00485 (K1T35_00485) 94675..95301 + 627 WP_255621440.1 hypothetical protein -
K1T35_RS00490 (K1T35_00490) 95307..96473 + 1167 WP_220258226.1 glutathionylspermidine synthase family protein -
K1T35_RS00495 (K1T35_00495) 96493..96954 + 462 WP_220258227.1 DUF350 domain-containing protein -
K1T35_RS00500 (K1T35_00500) 96958..97602 - 645 WP_220258228.1 endonuclease -
K1T35_RS00505 (K1T35_00505) 97666..97926 + 261 WP_220258229.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
K1T35_RS00510 (K1T35_00510) 97923..98315 + 393 WP_220258230.1 type II toxin-antitoxin system VapC family toxin Toxin
K1T35_RS00515 (K1T35_00515) 98315..98599 + 285 WP_220258231.1 hypothetical protein -
K1T35_RS00520 (K1T35_00520) 98638..99432 + 795 WP_220258232.1 HAD family hydrolase -
K1T35_RS00525 (K1T35_00525) 99723..100148 + 426 WP_220262296.1 phosphatase PAP2 family protein -
K1T35_RS00530 (K1T35_00530) 100145..101065 + 921 WP_220258233.1 decaprenyl-phosphate phosphoribosyltransferase -
K1T35_RS00535 (K1T35_00535) 101090..101977 + 888 WP_220258234.1 glucose-1-phosphate thymidylyltransferase RfbA -
K1T35_RS00540 (K1T35_00540) 101987..102964 + 978 WP_220258235.1 dTDP-glucose 4,6-dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-117)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-64)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 13839.84 Da        Isoelectric Point: 4.3568

>T211984 WP_220258230.1 NZ_CP080521:97923-98315 [Pseudonocardia sp. DSM 110487]
VKGLLATSVFIALESGRPLDEQRIPDETAVSVVTLAELQAGVLAATDIDVRARRLATLDAVADIELIDIDESAARAWARM
RVHLAGTGRRVNVNDLWIAAVAASRGLPVVTQDDDFGPVEGVMGLDVIRV

Download         Length: 393 bp

>T211984 NZ_CP106891:36452-36922 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACTCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCTGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9642.94 Da        Isoelectric Point: 11.8310

>AT211984 WP_220258229.1 NZ_CP080521:97666-97926 [Pseudonocardia sp. DSM 110487]
MSSVPSRELRNDTAGVLRRVEAGERVTVTVNGRPVAELVPVQRSRRSWIRRDELVARLRRVQADPGLRDDLARLAGDTTD
DLGPIR

Download         Length: 261 bp

>AT211984 NZ_CP106891:36012-36455 [Klebsiella pneumoniae]
ATGAAAACTTTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCCAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACTTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACGGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References