Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1350610..1351199 Replicon chromosome
Accession NC_007146
Organism Haemophilus influenzae 86-028NP

Toxin (Protein)


Gene name hicA Uniprot ID Q4QL51
Locus tag NTHI_RS06745 Protein ID WP_005653200.1
Coordinates 1350610..1350858 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q4QL50
Locus tag NTHI_RS06750 Protein ID WP_005653201.1
Coordinates 1350855..1351199 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTHI_RS06720 (NTHI1421) 1346090..1346722 + 633 WP_011272461.1 energy-coupling factor transporter transmembrane protein EcfT -
NTHI_RS06725 (NTHI1422) 1346724..1347350 + 627 WP_011272462.1 energy-coupling factor ABC transporter ATP-binding protein -
NTHI_RS06730 (NTHI1423) 1347457..1348647 - 1191 WP_005657030.1 aspartate/tyrosine/aromatic aminotransferase -
NTHI_RS06735 (NTHI1424) 1348787..1349875 - 1089 WP_005686592.1 5-(carboxyamino)imidazole ribonucleotide synthase -
NTHI_RS06740 (NTHI1425) 1349945..1350439 - 495 WP_005653194.1 5-(carboxyamino)imidazole ribonucleotide mutase -
NTHI_RS06745 (NTHI1426) 1350610..1350858 + 249 WP_005653200.1 type II toxin-antitoxin system HicA family toxin Toxin
NTHI_RS06750 (NTHI1427) 1350855..1351199 + 345 WP_005653201.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NTHI_RS06755 (NTHI1428) 1351243..1353852 + 2610 WP_011272463.1 aminopeptidase N -
NTHI_RS06760 (NTHI1429) 1353924..1354538 - 615 WP_005657019.1 riboflavin synthase -
NTHI_RS06765 (NTHI1430) 1354582..1355976 + 1395 WP_005657016.1 sodium-coupled multidrug efflux MATE transporter HmrM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9425.93 Da        Isoelectric Point: 10.4673

>T21198 WP_005653200.1 NC_007146:1350610-1350858 [Haemophilus influenzae 86-028NP]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

>T21198 NC_007146:1350610-1350858 [Haemophilus influenzae 86-028NP]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCTCACCCTGAAAATTATATTAAAGGTGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.04 Da        Isoelectric Point: 4.8151

>AT21198 WP_005653201.1 NC_007146:1350855-1351199 [Haemophilus influenzae 86-028NP]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIQEKIFREKPSLR

Download         Length: 345 bp

>AT21198 NC_007146:1350855-1351199 [Haemophilus influenzae 86-028NP]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTGTTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGCTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATCATAGCAGGCGATCGTTCTCTTAATGCTTTTGTTACGGAAGCGATTCAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M6BP03

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GMF9

References