Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 141936..142441 Replicon chromosome
Accession NZ_CP080518
Organism Pseudomonas aeruginosa strain YY322

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag KMW38_RS00655 Protein ID WP_003083773.1
Coordinates 141936..142217 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag KMW38_RS00660 Protein ID WP_003083775.1
Coordinates 142214..142441 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KMW38_RS00630 (KMW38_00630) 137187..138536 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
KMW38_RS00635 (KMW38_00635) 138585..139271 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
KMW38_RS00640 (KMW38_00640) 139372..140106 + 735 WP_003117208.1 GntR family transcriptional regulator -
KMW38_RS00645 (KMW38_00645) 140286..140696 + 411 WP_003110659.1 aegerolysin family protein -
KMW38_RS00650 (KMW38_00650) 140728..141636 - 909 WP_003083769.1 LysR family transcriptional regulator -
KMW38_RS00655 (KMW38_00655) 141936..142217 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
KMW38_RS00660 (KMW38_00660) 142214..142441 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
KMW38_RS00665 (KMW38_00665) 142616..143236 - 621 WP_003101226.1 hypothetical protein -
KMW38_RS00670 (KMW38_00670) 143337..143837 + 501 WP_003162763.1 LEA type 2 family protein -
KMW38_RS00675 (KMW38_00675) 143910..144251 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
KMW38_RS00680 (KMW38_00680) 144333..145760 - 1428 WP_003083784.1 GABA permease -
KMW38_RS00685 (KMW38_00685) 145929..147422 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T211977 WP_003083773.1 NZ_CP080518:c142217-141936 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T211977 NZ_CP106890:2055012-2055114 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT211977 WP_003083775.1 NZ_CP080518:c142441-142214 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT211977 NZ_CP106890:c2055120-2054976 [Klebsiella pneumoniae]
ACATATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGT
TGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References