Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/RHH(antitoxin) |
Location | 141936..142441 | Replicon | chromosome |
Accession | NZ_CP080518 | ||
Organism | Pseudomonas aeruginosa strain YY322 |
Toxin (Protein)
Gene name | parE | Uniprot ID | V6A7K8 |
Locus tag | KMW38_RS00655 | Protein ID | WP_003083773.1 |
Coordinates | 141936..142217 (-) | Length | 94 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | A0A1C7BDS9 |
Locus tag | KMW38_RS00660 | Protein ID | WP_003083775.1 |
Coordinates | 142214..142441 (-) | Length | 76 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KMW38_RS00630 (KMW38_00630) | 137187..138536 | + | 1350 | WP_003142411.1 | C4-dicarboxylate transporter DctA | - |
KMW38_RS00635 (KMW38_00635) | 138585..139271 | + | 687 | WP_003083762.1 | FadR/GntR family transcriptional regulator | - |
KMW38_RS00640 (KMW38_00640) | 139372..140106 | + | 735 | WP_003117208.1 | GntR family transcriptional regulator | - |
KMW38_RS00645 (KMW38_00645) | 140286..140696 | + | 411 | WP_003110659.1 | aegerolysin family protein | - |
KMW38_RS00650 (KMW38_00650) | 140728..141636 | - | 909 | WP_003083769.1 | LysR family transcriptional regulator | - |
KMW38_RS00655 (KMW38_00655) | 141936..142217 | - | 282 | WP_003083773.1 | type II toxin-antitoxin system toxin ParE | Toxin |
KMW38_RS00660 (KMW38_00660) | 142214..142441 | - | 228 | WP_003083775.1 | CopG family ribbon-helix-helix protein | Antitoxin |
KMW38_RS00665 (KMW38_00665) | 142616..143236 | - | 621 | WP_003101226.1 | hypothetical protein | - |
KMW38_RS00670 (KMW38_00670) | 143337..143837 | + | 501 | WP_003162763.1 | LEA type 2 family protein | - |
KMW38_RS00675 (KMW38_00675) | 143910..144251 | + | 342 | WP_003101229.1 | zinc ribbon domain-containing protein YjdM | - |
KMW38_RS00680 (KMW38_00680) | 144333..145760 | - | 1428 | WP_003083784.1 | GABA permease | - |
KMW38_RS00685 (KMW38_00685) | 145929..147422 | - | 1494 | WP_003101230.1 | CoA-acylating methylmalonate-semialdehyde dehydrogenase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10462.19 Da Isoelectric Point: 10.0435
>T211977 WP_003083773.1 NZ_CP080518:c142217-141936 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP
Download Length: 282 bp
>T211977 NZ_CP106890:2055012-2055114 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 76 a.a. Molecular weight: 8556.58 Da Isoelectric Point: 5.5740
>AT211977 WP_003083775.1 NZ_CP080518:c142441-142214 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ
Download Length: 228 bp
>AT211977 NZ_CP106890:c2055120-2054976 [Klebsiella pneumoniae]
ACATATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGT
TGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
ACATATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGT
TGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|