Detailed information of TA system TA211975

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/RHH(antitoxin)
• Location: 4429203..4429756
• Replicon: chromosome
• Accession: NZ_CP080512
• Organism: Pseudomonas protegens strain CM-YJ10_15-44

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: K1T36_RS19945
• Protein ID: WP_258571670.1
• Coordinates: 4429203..4429457 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: K1T36_RS19950
• Protein ID: WP_102864761.1
• Coordinates: 4429484..4429756 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K1T36_RS19925 (K1T36_19925)	4424843..4425811	-	969	WP_220222917.1	hypothetical protein	-
K1T36_RS19930 (K1T36_19930)	4426159..4426542	+	384	WP_220222918.1	nucleotide pyrophosphohydrolase	-
K1T36_RS19935 (K1T36_19935)	4426568..4428442	+	1875	WP_220222919.1	DUF2075 domain-containing protein	-
K1T36_RS19940 (K1T36_19940)	4428733..4429125	+	393	WP_220222920.1	DUF3077 domain-containing protein	-
K1T36_RS19945 (K1T36_19945)	4429203..4429457	-	255	WP_258571670.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K1T36_RS19950 (K1T36_19950)	4429484..4429756	-	273	WP_102864761.1	CopG family ribbon-helix-helix protein	Antitoxin
K1T36_RS19955 (K1T36_19955)	4430117..4432156	-	2040	WP_220222922.1	LTA synthase family protein	-
K1T36_RS19960 (K1T36_19960)	4432206..4432817	-	612	WP_220222923.1	hypothetical protein	-
K1T36_RS19965 (K1T36_19965)	4432817..4434112	-	1296	WP_220222924.1	sialidase family protein	-
K1T36_RS19970 (K1T36_19970)	4434158..4434703	-	546	WP_220222925.1	cytochrome b/b6 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-82)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-40)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9814.18 Da
• Isoelectric Point: 4.8893

>T211975 WP_258571670.1 NZ_CP080512:c4429457-4429203 [Pseudomonas protegens]
MERCRQFLVEKGPLIAQRAAQVIERQIARLEEDPEIGRPFPELPELRELIIDFGDSGYVALYRHERADDAVYILAFRHQK
EAGY

Nucleotide

• Length: 255 bp

>T211975 NZ_CP106890:772493-772978 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10466.69 Da
• Isoelectric Point: 6.0866

>AT211975 WP_102864761.1 NZ_CP080512:c4429756-4429484 [Pseudomonas protegens]
MATSIKIDDELKKRIQHLAGLRQRSSHWIMREAIAQYVEREEAREGFKQEALASWAAYQETGRHLTGEETRAWLNTWGTE
AEAELPKCHD

Nucleotide

• Length: 273 bp

>AT211975 NZ_CP106890:772203-772496 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA