Detailed information of TA system TA211972

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 1018636..1019174
• Replicon: chromosome
• Accession: NZ_CP080512
• Organism: Pseudomonas protegens strain CM-YJ10_15-44

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K1T36_RS04535
• Protein ID: WP_220223703.1
• Coordinates: 1018896..1019174 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7U9L9U0
• Locus tag: K1T36_RS04530
• Protein ID: WP_047283908.1
• Coordinates: 1018636..1018899 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K1T36_RS04515 (K1T36_04515)	1014619..1016904	-	2286	WP_220223702.1	TonB-dependent siderophore receptor	-
K1T36_RS04520 (K1T36_04520)	1017111..1017791	+	681	WP_011059221.1	Fe2+-dependent dioxygenase	-
K1T36_RS04525 (K1T36_04525)	1017795..1018580	+	786	WP_077933345.1	tetratricopeptide repeat protein	-
K1T36_RS04530 (K1T36_04530)	1018636..1018899	+	264	WP_047283908.1	ribbon-helix-helix domain-containing protein	Antitoxin
K1T36_RS04535 (K1T36_04535)	1018896..1019174	+	279	WP_220223703.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K1T36_RS04540 (K1T36_04540)	1019245..1020408	-	1164	WP_015634137.1	type III PLP-dependent enzyme	-
K1T36_RS04545 (K1T36_04545)	1021087..1022244	-	1158	WP_015634138.1	ABC transporter ATP-binding protein	-
K1T36_RS04550 (K1T36_04550)	1022241..1022894	-	654	WP_011059225.1	ABC transporter permease	-
K1T36_RS04555 (K1T36_04555)	1022907..1023800	-	894	WP_015634139.1	glycine betaine ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Ribbon-helix-helix protein, CopG (7-44)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10724.37 Da
• Isoelectric Point: 10.2944

>T211972 WP_220223703.1 NZ_CP080512:1018896-1019174 [Pseudomonas protegens]
MRQLKWTSKALSDLARLFEFLAQANRSTAARTVQSLVQAPDALLSNPRLGEQLEEFKPRDVRRLLVGHYEMRYEIQGMAL
SILSIWHVREDR

Nucleotide

• Length: 279 bp

>T211972 NZ_CP106888:c85185-84880 [Klebsiella pneumoniae]
ATGCAGTTCACCGTCTACGAATACACACGCGAGAGCCATTATCGTCTTTTTGTGGATGTGCAGAGCGACATTGTCGAGAC
GCCTGGGCGACGCATAGTGATCCCGTTGCTGGAATCGCACCACTTATCAGAAAAGGTTAATCAGCAGCTTTTCCCGGTGG
TTAGCGTCAATGGGAAAGAATACCGTGCCGTGACTTCCGAATTATCCGGAGTCTCTGTCAGTGTCATCGGCGACGCTGTG
GCCGATCTCAGCCATGAGGCAAATGCCATTAAAAATGCCCTGAACCTGATGTTCTGGGGCATTTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9676.08 Da
• Isoelectric Point: 5.6706

>AT211972 WP_047283908.1 NZ_CP080512:1018636-1018899 [Pseudomonas protegens]
MPATKVLTAHIPLDLADKVDQLASRLERSRAWVVKQALVAWVDQEEERRRLTLEALADVDAGRVVDHQSVLAWAQSLSGD
NPLPLPK

Nucleotide

• Length: 264 bp

>AT211972 NZ_CP106888:c85403-85185 [Klebsiella pneumoniae]
ATGAAACACAGAGCCAGCGTCACAGTAGACAAGGAACATTATCTGGAATTACTCGCGGCAGGCGTGAATATTTCGGGACT
GGTGAATGAGGCTATCGGACGGGAAGCCCGGCGCATCCAGGCTGAACGCTGGAAAGCAGAGAACCGGGAAGGGATGGAAG
AGGTAGCGAATTTCATCGCGCAGCACGGCTCTTTTGCCGACGAAAACCGGAGCTGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U9L9U0