Detailed information of TA system TA211970

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 178204..178720
• Replicon: chromosome
• Accession: NZ_CP080512
• Organism: Pseudomonas protegens strain CM-YJ10_15-44

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F9XXF1
• Locus tag: K1T36_RS00795
• Protein ID: WP_011058535.1
• Coordinates: 178439..178720 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q4KKD3
• Locus tag: K1T36_RS00790
• Protein ID: WP_011058534.1
• Coordinates: 178204..178449 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K1T36_RS00775 (K1T36_00775)	175698..177308	+	1611	WP_220223516.1	glycosyltransferase family 39 protein	-
K1T36_RS00780 (K1T36_00780)	177418..177879	+	462	WP_011058532.1	YbaK/EbsC family protein	-
K1T36_RS00785 (K1T36_00785)	177894..178139	+	246	WP_011058533.1	DUF2789 domain-containing protein	-
K1T36_RS00790 (K1T36_00790)	178204..178449	+	246	WP_011058534.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
K1T36_RS00795 (K1T36_00795)	178439..178720	+	282	WP_011058535.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K1T36_RS00800 (K1T36_00800)	178863..179291	+	429	WP_011058536.1	winged helix DNA-binding protein	-
K1T36_RS00805 (K1T36_00805)	179288..181375	+	2088	WP_041751900.1	FUSC family protein	-
K1T36_RS00810 (K1T36_00810)	181372..181581	+	210	WP_011058538.1	DUF1656 domain-containing protein	-
K1T36_RS00815 (K1T36_00815)	181578..182468	+	891	WP_220223517.1	HlyD family secretion protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-69)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10839.72 Da
• Isoelectric Point: 10.2298

>T211970 WP_011058535.1 NZ_CP080512:178439-178720 [Pseudomonas protegens]
MTYSLEFLPSAHKEWNKLGHTLREQFKKKLAERLEVPRIPADALHGLPDCYKIKLKASGYRLVYQVIEERVVVCVVAVGK
RERGTVYEQARKR

Nucleotide

• Length: 282 bp

>T211970 NZ_CP106887:36452-36922 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACTCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCTGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8799.10 Da
• Isoelectric Point: 4.3988

>AT211970 WP_011058534.1 NZ_CP080512:178204-178449 [Pseudomonas protegens]
MQSILADKAVSVSELKKNPSAVLSGAQGGPVAVLNHNRVMGYMVPAEVFEALMERLDDLELAEIIRERSHETPVPVSLDD
L

Nucleotide

• Length: 246 bp

>AT211970 NZ_CP106887:36012-36455 [Klebsiella pneumoniae]
ATGAAAACTTTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCCAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACTTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACGGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Structures

Toxin

• AlphaFold DB: F9XXF1

Antitoxin

• AlphaFold DB: Q4KKD3