21197

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1067846..1068477 Replicon chromosome
Accession NC_007146
Organism Haemophilus influenzae 86-028NP

Toxin (Protein)


Gene name vapC Uniprot ID Q4QLW0
Locus tag NTHI_RS05375 Protein ID WP_005651560.1
Coordinates 1067846..1068244 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q4QLV9
Locus tag NTHI_RS05380 Protein ID WP_005648011.1
Coordinates 1068244..1068477 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTHI_RS05355 (NTHI1115) 1063029..1064147 + 1119 WP_011272304.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
NTHI_RS05360 (NTHI1116) 1064148..1065170 + 1023 WP_005693292.1 outer membrane-stress sensor serine endopeptidase DegS -
NTHI_RS05365 (NTHI1118) 1065244..1066059 - 816 WP_011272305.1 DNA-formamidopyrimidine glycosylase -
NTHI_RS05370 (NTHI1119) 1066291..1067826 - 1536 WP_011272306.1 L-2,4-diaminobutyrate decarboxylase -
NTHI_RS05375 (NTHI1120) 1067846..1068244 - 399 WP_005651560.1 tRNA(fMet)-specific endonuclease VapC Toxin
NTHI_RS05380 (NTHI1121) 1068244..1068477 - 234 WP_005648011.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
NTHI_RS05385 (NTHI1122) 1068624..1069988 - 1365 WP_005651563.1 diaminobutyrate--2-oxoglutarate transaminase -
NTHI_RS05390 (NTHI1123) 1070335..1070505 - 171 WP_005613503.1 50S ribosomal protein L33 -
NTHI_RS05395 (NTHI1124) 1070517..1070753 - 237 WP_005542826.1 50S ribosomal protein L28 -
NTHI_RS05400 (NTHI1125) 1070967..1071632 - 666 WP_013526173.1 DNA repair protein RadC -
NTHI_RS05405 (NTHI1126) 1071795..1072997 + 1203 WP_011272308.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15115.46 Da        Isoelectric Point: 8.0514

>T21197 WP_005651560.1 NC_007146:c1068244-1067846 [Haemophilus influenzae 86-028NP]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Download         Length: 399 bp

>T21197 NC_007146:c1068244-1067846 [Haemophilus influenzae 86-028NP]
GTGTTGAAATATATGCTTGATACTAACATTGTGATTTACGTGATTAAGCGTAGGCCATTGGAAATTCTTTCTCGCTTTAA
TCAAAATGCAGGAAAAATGTGCGTGAGTAGCATTACTGTGGCTGAACTCTATTATGGAGCTGAAAAAAGCGAATATCCCG
AAAGAAACATTGCGGTTATTGAAGATTTCTTATCACGCCTCACCATTTTAGATTACCAACCAAAGCATGCAGCTCATTTC
GGCAATATTAAAGCTGAACTCTCTAAACAAGGGAAATTGATTGGCGAAAATGATATTCATATAGCTGCTCATGCTCGTAG
TGAAGGGTTAATTCTGGTTAGTAACAATTTAAGAGAATTTGAGCGAGTTATAGCATTACGTACAGAAAATTGGGTGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8880.98 Da        Isoelectric Point: 4.4013

>AT21197 WP_005648011.1 NC_007146:c1068477-1068244 [Haemophilus influenzae 86-028NP]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Download         Length: 234 bp

>AT21197 NC_007146:c1068477-1068244 [Haemophilus influenzae 86-028NP]
ATGATTGAAGCCTCTGTTTTTATGACTAATCGAAGTCAAGCTGTGCGTTTGCCCGCTGAAGTTCGCTTTTCTGAAGAAAT
CAAAAAATTATCGGTTCGTGTATCGGGCAGTGATCGGATTTTATCGCCTCTCAACCAATCTTGGGATAGTTTTTTCTTGA
ATGATCAAGCAGTTAGCGATGATTTTATGAATGAACGAGAAATTGCATTTCAACCAGAGCGTGAGGCTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4QLW0

Antitoxin

Source ID Structure
AlphaFold DB A0A806DGS0

References