Detailed information of TA system TA211967

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 2531879..2533137
• Replicon: chromosome
• Accession: NZ_CP080511
• Organism: Pseudomonas aeruginosa strain DJ06

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9I4U4
• Locus tag: K1T67_RS11800
• Protein ID: WP_003112528.1
• Coordinates: 2532382..2533137 (+)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: K1T67_RS11795
• Protein ID: WP_003086329.1
• Coordinates: 2531879..2532247 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K1T67_RS11775 (K1T67_11775)	2528042..2528317	+	276	WP_010792073.1	zinc ribbon domain-containing protein	-
K1T67_RS11780 (K1T67_11780)	2528320..2528796	-	477	WP_003112531.1	hypothetical protein	-
K1T67_RS11785 (K1T67_11785)	2528875..2530464	+	1590	WP_079280589.1	aldehyde dehydrogenase family protein	-
K1T67_RS11790 (K1T67_11790)	2530520..2531806	+	1287	WP_003163134.1	FAD-binding oxidoreductase	-
K1T67_RS11795 (K1T67_11795)	2531879..2532247	+	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
K1T67_RS11800 (K1T67_11800)	2532382..2533137	+	756	WP_003112528.1	RES family NAD+ phosphorylase	Toxin
K1T67_RS11805 (K1T67_11805)	2533906..2535267	+	1362	WP_003081943.1	DNA recombination protein RmuC	-
K1T67_RS11810 (K1T67_11810)	2535423..2537966	-	2544	WP_023110293.1	acyl-homoserine-lactone acylase QuiP	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28278.42 Da
• Isoelectric Point: 7.7294

>T211967 WP_003112528.1 NZ_CP080511:2532382-2533137 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T211967 NZ_CP106886:c4897323-4897039 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT211967 WP_003086329.1 NZ_CP080511:2531879-2532247 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT211967 NZ_CP106886:c4897555-4897313 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Toxin

• AlphaFold DB: Q9I4U4

Antitoxin

• AlphaFold DB: V6AJU7