211963

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 473874..474379 Replicon chromosome
Accession NZ_CP080511
Organism Pseudomonas aeruginosa strain DJ06

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag K1T67_RS02210 Protein ID WP_003083773.1
Coordinates 474098..474379 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag K1T67_RS02205 Protein ID WP_003083775.1
Coordinates 473874..474101 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1T67_RS02180 (K1T67_02180) 468892..470385 + 1494 WP_023109527.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
K1T67_RS02185 (K1T67_02185) 470554..471981 + 1428 WP_003083784.1 GABA permease -
K1T67_RS02190 (K1T67_02190) 472063..472404 - 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
K1T67_RS02195 (K1T67_02195) 472477..472977 - 501 WP_003101228.1 LEA type 2 family protein -
K1T67_RS02200 (K1T67_02200) 473078..473698 + 621 WP_003101226.1 hypothetical protein -
K1T67_RS02205 (K1T67_02205) 473874..474101 + 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
K1T67_RS02210 (K1T67_02210) 474098..474379 + 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
K1T67_RS02215 (K1T67_02215) 474679..475587 + 909 WP_003083769.1 LysR family transcriptional regulator -
K1T67_RS02220 (K1T67_02220) 475619..476029 - 411 WP_003101225.1 aegerolysin family protein -
K1T67_RS02225 (K1T67_02225) 476209..476943 - 735 WP_003117208.1 GntR family transcriptional regulator -
K1T67_RS02230 (K1T67_02230) 477044..477730 - 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
K1T67_RS02235 (K1T67_02235) 477779..479128 - 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T211963 WP_003083773.1 NZ_CP080511:474098-474379 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T211963 NZ_CP106886:2055000-2055102 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT211963 WP_003083775.1 NZ_CP080511:473874-474101 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT211963 NZ_CP106886:c2055108-2054964 [Klebsiella pneumoniae]
ACATATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGT
TGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References