Detailed information of TA system TA021196

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 792077..792681
• Replicon: chromosome
• Accession: NC_007146
• Organism: Haemophilus influenzae 86-028NP

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q4QMK7
• Locus tag: NTHI_RS04020
• Protein ID: WP_011272186.1
• Coordinates: 792373..792681 (+)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q4QMK8
• Locus tag: NTHI_RS04015
• Protein ID: WP_005692346.1
• Coordinates: 792077..792373 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NTHI_RS04000 (NTHI0835)	787843..789228	+	1386	WP_011272183.1	L-seryl-tRNA(Sec) selenium transferase	-
NTHI_RS04005 (NTHI0836)	789225..791084	+	1860	WP_011272184.1	selenocysteine-specific translation elongation factor	-
NTHI_RS04010 (NTHI0837)	791103..791957	+	855	WP_011272185.1	DUF3298 domain-containing protein	-
NTHI_RS04015 (NTHI0838)	792077..792373	+	297	WP_005692346.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
NTHI_RS04020 (NTHI0839)	792373..792681	+	309	WP_011272186.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
NTHI_RS04025 (NTHI0840)	792738..795863	-	3126	WP_138154501.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
NTHI_RS04030 (NTHI0843)	796227..797525	+	1299	WP_006995277.1	trigger factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (8-98)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-93)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11929.69 Da
• Isoelectric Point: 7.8904

>T21196 WP_011272186.1 NC_007146:792373-792681 [Haemophilus influenzae 86-028NP]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIYCLLNRLPLPENYQDHALVGEWKGYRDCHIQGNLVLIYQYV
IHDEFDELKFSRLNTHSQTALK

Nucleotide

• Length: 309 bp

>T21196 NC_007146:792373-792681 [Haemophilus influenzae 86-028NP]
ATGTCAGAAGAGAAGCCATTAAAAGTAAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGCTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATATACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGCAATTTGGTACTGATTTACCAATACGTT
ATACACGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11003.27 Da
• Isoelectric Point: 4.2845

>AT21196 WP_005692346.1 NC_007146:792077-792373 [Haemophilus influenzae 86-028NP]
MALTNSSISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPIDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Nucleotide

• Length: 297 bp

>AT21196 NC_007146:792077-792373 [Haemophilus influenzae 86-028NP]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGCAAACAAAATCAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTATTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTCTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Structures

Toxin

• AlphaFold DB: Q4QMK7

Antitoxin

• AlphaFold DB: Q4QMK8