Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 469907..470544 Replicon chromosome
Accession NZ_CP080509
Organism Bacillus sp. 7D3

Toxin (Protein)


Gene name mazF Uniprot ID G4NU33
Locus tag KTJ85_RS02270 Protein ID WP_003156187.1
Coordinates 470194..470544 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID I2HMS5
Locus tag KTJ85_RS02265 Protein ID WP_003156188.1
Coordinates 469907..470188 (+) Length 94 a.a.

Genomic Context

KTJ85_RS02250KTJ85_RS19445KTJ85_RS02260KTJ85_RS02265KTJ85_RS02270KTJ85_RS02275KTJ85_RS02280KTJ85_RS02285KTJ85_RS02290KTJ85_RS02295KTJ85_RS02300KTJ85_RS02305KTJ85_RS02310KTJ85_RS02245
Location: 466960..467325 (366 bp)
Type: Others
Protein ID: WP_115998347.1
Location: 467490..468497 (1008 bp)
Type: Others
Protein ID: WP_065980767.1
Location: 468619..469788 (1170 bp)
Type: Others
Protein ID: WP_115998346.1
Location: 469907..470188 (282 bp)
Type: Antitoxin
Protein ID: WP_003156188.1
Location: 470194..470544 (351 bp)
Type: Toxin
Protein ID: WP_003156187.1
Location: 470665..471486 (822 bp)
Type: Others
Protein ID: WP_065980769.1
Location: 471491..471856 (366 bp)
Type: Others
Protein ID: WP_003156180.1
Location: 471859..472260 (402 bp)
Type: Others
Protein ID: WP_065980770.1
Location: 472272..473279 (1008 bp)
Type: Others
Protein ID: WP_013351098.1
Location: 473343..473672 (330 bp)
Type: Others
Protein ID: WP_014469786.1
Location: 473669..474151 (483 bp)
Type: Others
Protein ID: WP_003156173.1
Location: 474117..474905 (789 bp)
Type: Others
Protein ID: WP_013351101.1
Location: 474905..475507 (603 bp)
Type: Others
Protein ID: WP_065980772.1
Location: 466268..466867 (600 bp)
Type: Others
Protein ID: WP_013351092.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KTJ85_RS02245 (KTJ85_02245)466268..466867-600WP_013351092.1rhomboid family intramembrane serine protease-
KTJ85_RS02250 (KTJ85_02250)466960..467325+366WP_115998347.1holo-ACP synthase-
KTJ85_RS19445467490..468497+1008WP_065980767.1outer membrane lipoprotein carrier protein LolA-
KTJ85_RS02260 (KTJ85_02260)468619..469788+1170WP_115998346.1alanine racemase-
KTJ85_RS02265 (KTJ85_02265)469907..470188+282WP_003156188.1type II toxin-antitoxin system antitoxin EndoAIAntitoxin
KTJ85_RS02270 (KTJ85_02270)470194..470544+351WP_003156187.1type II toxin-antitoxin system endoribonuclease NdoAToxin
KTJ85_RS02275 (KTJ85_02275)470665..471486+822WP_065980769.1STAS domain-containing protein-
KTJ85_RS02280 (KTJ85_02280)471491..471856+366WP_003156180.1RsbT antagonist protein RsbS-
KTJ85_RS02285 (KTJ85_02285)471859..472260+402WP_065980770.1anti-sigma regulatory factor-
KTJ85_RS02290 (KTJ85_02290)472272..473279+1008WP_013351098.1PP2C family protein-serine/threonine phosphatase-
KTJ85_RS02295 (KTJ85_02295)473343..473672+330WP_014469786.1anti-sigma factor antagonist-
KTJ85_RS02300 (KTJ85_02300)473669..474151+483WP_003156173.1anti-sigma B factor RsbW-
KTJ85_RS02305 (KTJ85_02305)474117..474905+789WP_013351101.1RNA polymerase sigma factor SigB-
KTJ85_RS02310 (KTJ85_02310)474905..475507+603WP_065980772.1PP2C family serine/threonine-protein phosphatase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8781

>T211959 WP_003156187.1 NZ_CP080509:470194-470544 [Bacillus sp. 7D3]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF

Download         Length: 351 bp

>T211959 NZ_CP106886:325933-326301 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10562.92 Da        Isoelectric Point: 6.4706

>AT211959 WP_003156188.1 NZ_CP080509:469907-470188 [Bacillus sp. 7D3]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG

Download         Length: 282 bp

>AT211959 NZ_CP106886:325715-325936 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB4MDX
PDB4ME7
PDB1NE8

Antitoxin

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Source
ID
Structure
AlphaFold DBI2HMS5

References