Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | spoIISABC/SpoIISA-SpoIISB |
| Location | 3407042..3407958 | Replicon | chromosome |
| Accession | NZ_CP080508 | ||
| Organism | Bacillus subtilis strain HD15 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | O34853 |
| Locus tag | K0V03_RS18215 | Protein ID | WP_003244695.1 |
| Coordinates | 3407212..3407958 (-) | Length | 249 a.a. |
Antitoxin (Protein)
| Gene name | spoIISB | Uniprot ID | G4EXD8 |
| Locus tag | K0V03_RS18210 | Protein ID | WP_003232646.1 |
| Coordinates | 3407042..3407212 (-) | Length | 57 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K0V03_RS18175 (K0V03_18175) | 3403905..3404234 | + | 330 | WP_085186201.1 | XkdW family protein | - |
| K0V03_RS18180 (K0V03_18180) | 3404231..3404395 | + | 165 | WP_085186199.1 | XkdX family protein | - |
| K0V03_RS18185 (K0V03_18185) | 3404439..3405278 | + | 840 | WP_085186197.1 | phage-like element PBSX protein XepA | - |
| K0V03_RS18190 (K0V03_18190) | 3405331..3405600 | + | 270 | WP_003232655.1 | hemolysin XhlA family protein | - |
| K0V03_RS18195 (K0V03_18195) | 3405613..3405876 | + | 264 | WP_003232653.1 | phage holin | - |
| K0V03_RS18200 (K0V03_18200) | 3405889..3406782 | + | 894 | WP_003245230.1 | N-acetylmuramoyl-L-alanine amidase | - |
| K0V03_RS18205 (K0V03_18205) | 3406819..3406956 | - | 138 | WP_003232648.1 | three component toxin-antitoxin-antitoxin system antitoxin SpoIISC | - |
| K0V03_RS18210 (K0V03_18210) | 3407042..3407212 | - | 171 | WP_003232646.1 | three component toxin-antitoxin-antitoxin system antitoxin SpoIISB | Antitoxin |
| K0V03_RS18215 (K0V03_18215) | 3407212..3407958 | - | 747 | WP_003244695.1 | toxin-antitoxin-antitoxin system toxin SpoIISA | Toxin |
| K0V03_RS18220 (K0V03_18220) | 3408068..3409069 | - | 1002 | WP_014479569.1 | inorganic phosphate transporter | - |
| K0V03_RS18225 (K0V03_18225) | 3409082..3409699 | - | 618 | WP_003218470.1 | DUF47 domain-containing protein | - |
| K0V03_RS18230 (K0V03_18230) | 3409975..3411291 | - | 1317 | WP_085186195.1 | serine/threonine exchanger | - |
| K0V03_RS18235 (K0V03_18235) | 3411680..3412630 | + | 951 | WP_085186193.1 | ring-cleaving dioxygenase | - |
| K0V03_RS22360 | 3412740..3412841 | + | 102 | Protein_3556 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 249 a.a. Molecular weight: 29061.50 Da Isoelectric Point: 4.6191
>T211958 WP_003244695.1 NZ_CP080508:c3407958-3407212 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG
Download Length: 747 bp
>T211958 NZ_CP106885:5900038-5900220 [Achromobacter spanius]
ATGAACAGCCGCGAGATCATCAGACAGCTTCGCCAAGCGGGCTGGGTATTCCGACATGCGAAAGGCTCGCATCACATTTT
CGTCCACCCGCAAAAACCTGGGCATATCAGCGTGCCTCACCCCAAGAAAGACTTGGGAATCGGACTGGTTACGAAGCTGC
TGACGCAAGCCGGCCTGAAGTAG
ATGAACAGCCGCGAGATCATCAGACAGCTTCGCCAAGCGGGCTGGGTATTCCGACATGCGAAAGGCTCGCATCACATTTT
CGTCCACCCGCAAAAACCTGGGCATATCAGCGTGCCTCACCCCAAGAAAGACTTGGGAATCGGACTGGTTACGAAGCTGC
TGACGCAAGCCGGCCTGAAGTAG
Antitoxin
Download Length: 57 a.a. Molecular weight: 6654.72 Da Isoelectric Point: 11.0203
>AT211958 WP_003232646.1 NZ_CP080508:c3407212-3407042 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA
Download Length: 171 bp
>AT211958 NZ_CP106885:5900270-5900662 [Achromobacter spanius]
ATGAAATATCCAATCGCCATTGAACCCGGCAGCGAGACGCAAGCGTGGGGCGTCGTCGTGCCAGATCTGCCGGGCTGCTT
TTCCGCCGCCGACTCAGGCATAGACGAAGCTATCGAGAACGCAAAAGAAGCGATCGAACTGTGGATTGAAACCGCGTTGG
ATAGTGGCACCCCCGTGCCCGTTGCCACCAGCATTGCGGGTCACCAAGCGAATCCAGAATTCGCAGGCTGGATTTGGGCC
ATCGTTGAAATCGATCCGGCCGTCATGGACGACACCATCGAACGCATCAACATCACGCTGCCCCGCCGAATCCTTGCAAG
GATCGACGCCAAAGCGCGTGCGGCGGGAGAAAGCCGATCTGGCTACATCGCTCATCTGGCGTTGACGCACTAG
ATGAAATATCCAATCGCCATTGAACCCGGCAGCGAGACGCAAGCGTGGGGCGTCGTCGTGCCAGATCTGCCGGGCTGCTT
TTCCGCCGCCGACTCAGGCATAGACGAAGCTATCGAGAACGCAAAAGAAGCGATCGAACTGTGGATTGAAACCGCGTTGG
ATAGTGGCACCCCCGTGCCCGTTGCCACCAGCATTGCGGGTCACCAAGCGAATCCAGAATTCGCAGGCTGGATTTGGGCC
ATCGTTGAAATCGATCCGGCCGTCATGGACGACACCATCGAACGCATCAACATCACGCTGCCCCGCCGAATCCTTGCAAG
GATCGACGCCAAAGCGCGTGCGGCGGGAGAAAGCCGATCTGGCTACATCGCTCATCTGGCGTTGACGCACTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|