Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 2532937..2533573 | Replicon | chromosome |
| Accession | NZ_CP080508 | ||
| Organism | Bacillus subtilis strain HD15 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | G4NU33 |
| Locus tag | K0V03_RS13380 | Protein ID | WP_003156187.1 |
| Coordinates | 2533223..2533573 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | G4NU32 |
| Locus tag | K0V03_RS13375 | Protein ID | WP_003225183.1 |
| Coordinates | 2532937..2533218 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K0V03_RS13355 (K0V03_13355) | 2529296..2529895 | - | 600 | WP_003246687.1 | rhomboid family intramembrane serine protease | - |
| K0V03_RS13360 (K0V03_13360) | 2529990..2530355 | + | 366 | WP_003234281.1 | holo-ACP synthase | - |
| K0V03_RS13365 (K0V03_13365) | 2530521..2531537 | + | 1017 | WP_003234282.1 | outer membrane lipoprotein carrier protein LolA | - |
| K0V03_RS13370 (K0V03_13370) | 2531652..2532821 | + | 1170 | WP_003234284.1 | alanine racemase | - |
| K0V03_RS13375 (K0V03_13375) | 2532937..2533218 | + | 282 | WP_003225183.1 | type II toxin-antitoxin system antitoxin EndoAI | Antitoxin |
| K0V03_RS13380 (K0V03_13380) | 2533223..2533573 | + | 351 | WP_003156187.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
| K0V03_RS13385 (K0V03_13385) | 2533688..2534512 | + | 825 | WP_009966610.1 | RsbT co-antagonist protein RsbRA | - |
| K0V03_RS13390 (K0V03_13390) | 2534517..2534882 | + | 366 | WP_015715277.1 | RsbT antagonist protein RsbS | - |
| K0V03_RS13395 (K0V03_13395) | 2534886..2535287 | + | 402 | WP_003246640.1 | serine/threonine-protein kinase RsbT | - |
| K0V03_RS13400 (K0V03_13400) | 2535299..2536306 | + | 1008 | WP_003234295.1 | phosphoserine phosphatase RsbU | - |
| K0V03_RS13405 (K0V03_13405) | 2536368..2536697 | + | 330 | WP_003234298.1 | anti-sigma factor antagonist RsbV | - |
| K0V03_RS13410 (K0V03_13410) | 2536694..2537176 | + | 483 | WP_003234299.1 | anti-sigma B factor RsbW | - |
| K0V03_RS13415 (K0V03_13415) | 2537142..2537930 | + | 789 | WP_003246715.1 | RNA polymerase sigma factor SigB | - |
| K0V03_RS13420 (K0V03_13420) | 2537930..2538529 | + | 600 | WP_070548596.1 | phosphoserine phosphatase RsbX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12977.98 Da Isoelectric Point: 4.8781
>T211957 WP_003156187.1 NZ_CP080508:2533223-2533573 [Bacillus subtilis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
Download Length: 351 bp
>T211957 NZ_CP106885:c3663046-3662627 [Achromobacter spanius]
ATGATTCTGCTGGACACCAATGTCATCTCCGAGCCGCTGCGCCAGGCGCCCGCCGACGCCGTCATCGAATGGATAGACCG
GCAGCCCCTGGAAACCTTGTTTCTTTCCGCCGTCACCGTCGCTGAATTGCGCTTTGGCGTGGCCTGCATGCCAGTGGGAA
AACGGCGCGACGCCTTGCATGGCGACCTGGAACAGCGCGTCCTGGCCCTGTTTGCCGGGCGCATCCTGGCTTTCGATACG
TCCGCCAGCCTGGAATACGTCGCGCTGATGGCGCGTGCGCGGGCCTCGGGCCAGGCCATCGGCGGGCCAGACGGCTACAT
CGCCGCCACCGCCGCCGCGCACGGGATGAGCGTCGCGACCCGGGACGTGGCGCCCTTTGAAGCCGCCGGCGTGTCCGTCA
TCAACCCGTGGGGCGCCTAG
ATGATTCTGCTGGACACCAATGTCATCTCCGAGCCGCTGCGCCAGGCGCCCGCCGACGCCGTCATCGAATGGATAGACCG
GCAGCCCCTGGAAACCTTGTTTCTTTCCGCCGTCACCGTCGCTGAATTGCGCTTTGGCGTGGCCTGCATGCCAGTGGGAA
AACGGCGCGACGCCTTGCATGGCGACCTGGAACAGCGCGTCCTGGCCCTGTTTGCCGGGCGCATCCTGGCTTTCGATACG
TCCGCCAGCCTGGAATACGTCGCGCTGATGGCGCGTGCGCGGGCCTCGGGCCAGGCCATCGGCGGGCCAGACGGCTACAT
CGCCGCCACCGCCGCCGCGCACGGGATGAGCGTCGCGACCCGGGACGTGGCGCCCTTTGAAGCCGCCGGCGTGTCCGTCA
TCAACCCGTGGGGCGCCTAG
Antitoxin
Download Length: 94 a.a. Molecular weight: 10546.92 Da Isoelectric Point: 6.4708
>AT211957 WP_003225183.1 NZ_CP080508:2532937-2533218 [Bacillus subtilis]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG
Download Length: 282 bp
>AT211957 NZ_CP106885:c3663294-3663043 [Achromobacter spanius]
ATGCCTATGTTGACCGTGAGAAATATCTCTGAAGAGGTACATCGCGCCCTGCGCGTGCGCGCCGCCCAGCATGGCCGAAG
CACCGAAGCCGAGGTCCGCGCCATTCTTGAAGACGCCGTCAAGCCTGAAGGGCGCGTCAAGCTGGGTTCGCTGCTTCTGC
AGATCGGCCGCCAGGCCAGGCTCACCGACGAGGAAGCCGCCTTGTTCGACCAACGCGACAAGGCGCCCGCCGCCCCACCG
AGGTTTGAATGA
ATGCCTATGTTGACCGTGAGAAATATCTCTGAAGAGGTACATCGCGCCCTGCGCGTGCGCGCCGCCCAGCATGGCCGAAG
CACCGAAGCCGAGGTCCGCGCCATTCTTGAAGACGCCGTCAAGCCTGAAGGGCGCGTCAAGCTGGGTTCGCTGCTTCTGC
AGATCGGCCGCCAGGCCAGGCTCACCGACGAGGAAGCCGCCTTGTTCGACCAACGCGACAAGGCGCCCGCCGCCCCACCG
AGGTTTGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|