Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/DUF433(antitoxin)
Location 2353810..2354147 Replicon chromosome
Accession NZ_CP080507
Organism Horticoccus luteus strain KSB-15

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K0B96_RS09785 Protein ID WP_220160723.1
Coordinates 2353810..2353923 (-) Length 38 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K0B96_RS09790 Protein ID WP_255558607.1
Coordinates 2353929..2354147 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0B96_RS09750 (K0B96_09750) 2349455..2350219 - 765 WP_220160716.1 SDR family oxidoreductase -
K0B96_RS09755 (K0B96_09755) 2350216..2351295 - 1080 WP_220160717.1 mannonate dehydratase -
K0B96_RS09760 (K0B96_09760) 2351309..2351584 - 276 WP_220160718.1 hypothetical protein -
K0B96_RS09765 (K0B96_09765) 2351780..2352103 - 324 WP_220160719.1 DUF5615 family PIN-like protein -
K0B96_RS09770 (K0B96_09770) 2352100..2352366 - 267 WP_220160720.1 DUF433 domain-containing protein -
K0B96_RS09780 (K0B96_09780) 2353603..2353779 - 177 WP_220160722.1 hypothetical protein -
K0B96_RS09785 (K0B96_09785) 2353810..2353923 - 114 WP_220160723.1 DUF5615 family PIN-like protein Toxin
K0B96_RS09790 (K0B96_09790) 2353929..2354147 - 219 WP_255558607.1 DUF433 domain-containing protein Antitoxin
K0B96_RS09795 (K0B96_09795) 2354266..2354433 - 168 Protein_1930 tyrosine-type recombinase/integrase -
K0B96_RS09800 (K0B96_09800) 2355503..2356807 - 1305 WP_220160725.1 RHS repeat-associated core domain-containing protein -
K0B96_RS09805 (K0B96_09805) 2357152..2357571 - 420 WP_220160726.1 PIN domain-containing protein -
K0B96_RS09810 (K0B96_09810) 2357568..2357807 - 240 WP_220166618.1 hypothetical protein -
K0B96_RS09820 (K0B96_09820) 2358386..2358859 - 474 WP_220160728.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Domain of unknown function DUF5615

(2-37)

Antitoxin

Protein of unknown function DUF433

(4-59)


Sequences

Toxin        


Download         Length: 38 a.a.        Molecular weight: 3819.41 Da        Isoelectric Point: 4.2645

>T211956 WP_220160723.1 NZ_CP080507:c2353923-2353810 [Horticoccus luteus]
MVDAQLPPALARWLAEAGCEAQAVREIGLRGAVDGAI

Download         Length: 114 bp

>T211956 NZ_CP106885:c2706321-2706139 [Achromobacter spanius]
ATGAATAGCGCCGACATCATCAAACGACTTAAAGCGGATGGCTGGTATCTCGTGCACAGCGTCGGATCACACCACCAGTT
CAAACATCCAACCAAGCGCGGCAAGGTGACCGTGCCTCACCCGCGCAAAGACCTTCCAGCGCCGACAGCGCACAGCATTC
TCAAGCAAGCCGGCTTGAGATAG

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 7865.01 Da        Isoelectric Point: 4.4702

>AT211956 WP_255558607.1 NZ_CP080507:c2354147-2353929 [Horticoccus luteus]
MERITFNPNQCGGRPCIRGMRIRVKDVLDLVAAGVPEADILADYPDLEADDIKASLEYAAAQLDHPVLVASR

Download         Length: 219 bp

>AT211956 NZ_CP106885:c2706115-2705726 [Achromobacter spanius]
GTGCTTTACCTCATTTACGTACACAAGGAAAAGGGCAGCGCCTACGGAGCTTCCTTTCCGGATTTTCCGGGCTGCCATGC
GGCGGCGACCACGCTCCAAGAGTTGCCGTCCGCAGCGCAGGAAGCGGTTGAAGCCCATTTTTTCGGTGAAACGCAGCCCA
TCCCCTCACCCAGTGCGCCGGATGTATGGATGCAAAAGAAGGCGTTTCAGGGCGGCTTCTGGATGCTCGTCGATATTGAC
CTGTCCAAAGTCAACACCAAGGCCGTCCGGCTCAACATCAGCCTGCCCGAAAACCTTGTGCATAGGATTGACGCAGTGGC
CAGAGCGCGTCGGTTGTCGCGCTCTGCCTTCCTCGCCCTGGCAGCGGAACATGAAATGGAAGCGGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References