Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 254313..254956 Replicon chromosome
Accession NZ_CP080507
Organism Horticoccus luteus strain KSB-15

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K0B96_RS00960 Protein ID WP_220162777.1
Coordinates 254558..254956 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K0B96_RS00955 Protein ID WP_220162775.1
Coordinates 254313..254540 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0B96_RS00925 (K0B96_00925) 249742..250050 - 309 WP_220162766.1 YhbY family RNA-binding protein -
K0B96_RS00930 (K0B96_00930) 250132..250821 - 690 WP_220162768.1 pseudouridine synthase -
K0B96_RS00935 (K0B96_00935) 250964..252265 + 1302 WP_255558787.1 sugar ABC transporter substrate-binding protein -
K0B96_RS00940 (K0B96_00940) 252262..253152 + 891 WP_220162770.1 sugar ABC transporter permease -
K0B96_RS00945 (K0B96_00945) 253149..254024 + 876 WP_220162772.1 carbohydrate ABC transporter permease -
K0B96_RS00950 (K0B96_00950) 254094..254258 + 165 WP_220162774.1 hypothetical protein -
K0B96_RS00955 (K0B96_00955) 254313..254540 + 228 WP_220162775.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
K0B96_RS00960 (K0B96_00960) 254558..254956 + 399 WP_220162777.1 type II toxin-antitoxin system VapC family toxin Toxin
K0B96_RS00965 (K0B96_00965) 255246..256412 + 1167 WP_220162779.1 cation:proton antiporter -
K0B96_RS00970 (K0B96_00970) 256616..256942 - 327 WP_220162781.1 hypothetical protein -
K0B96_RS00975 (K0B96_00975) 257075..257704 - 630 WP_220162783.1 hypothetical protein -
K0B96_RS00980 (K0B96_00980) 257768..258751 + 984 WP_220162785.1 WYL domain-containing transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14612.04 Da        Isoelectric Point: 7.8460

>T211953 WP_220162777.1 NZ_CP080507:254558-254956 [Horticoccus luteus]
MRYLLDTDICIYIIKQRPASVFKRFKPIPVGDIGISSITYSELCFGVSKSQQVARNLAALQSFVSPLEIIPYDDTVGLFY
GKVRHELESAGKPIDPLDTLIAAHAMSLAAILVTNNAKEFRRVQGLAVEVWA

Download         Length: 399 bp

>T211953 NZ_CP106885:1457578-1457787 [Achromobacter spanius]
ATGCATGGGAATTTCGGCGACGTAGAGGCGGTGGGTGAGGGCGTCAGTGAAATGCGCGTGAGTATTGGCGCCGGCTACCG
CCTGTATTACGCCCGGGCCGACGAGCTGGTCTACGTGCTGCTTTGTGGCGGTGACAAGACCAGCCAGGCCAGGGATATCG
CCCGCGCCAAACGCCTTTGGACGGACATTAAGCGGAGCATCGAGAAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8632.81 Da        Isoelectric Point: 10.2690

>AT211953 WP_220162775.1 NZ_CP080507:254313-254540 [Horticoccus luteus]
MDTAKLFKNGRSQAVRLPQQYRFPGDQVFIRRFGKAIVLLPEKNSWDVLIESTKEFSDDFLAGRNQGTSDKREAL

Download         Length: 228 bp

>AT211953 NZ_CP106885:1457784-1458092 [Achromobacter spanius]
ATGAGCAAATTACGCGACTTCGACGCAGCGAATTATTTGAAAGATGACGAAACGATCGCGCATTACCTGGCCGACGCGGC
AGCGGAGGACGATCCTGATGCGTTCCTGCAAGCCCTAGGCGACGTGGCGCGCGCGCGCGGCATCACAGAAATCGCTCGTG
AAACAGGGCTTGCCAGAACGAATCTTTATCGGGTGCTCGCGCCCGGCGCGAACCCCAGCTATCACACCCTGCGCAAGGTC
ATGAACGCGCTTGGTGTATCGCTCACCGCCCTTGTCAGGCGCAAATCCGATCCCACGCCGCAAGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References