Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 2475103..2475716 Replicon chromosome
Accession NZ_CP080494
Organism Pseudomonas sp. So3.2b

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag K1X80_RS11270 Protein ID WP_220172894.1
Coordinates 2475465..2475716 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag K1X80_RS11265 Protein ID WP_057959161.1
Coordinates 2475103..2475468 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1X80_RS28140 2470557..2470778 + 222 Protein_2219 biotin/lipoyl-binding protein -
K1X80_RS28145 2470966..2471658 + 693 WP_258571554.1 HlyD family secretion protein -
K1X80_RS11250 (K1X80_11250) 2471648..2473168 + 1521 WP_057959158.1 MDR family MFS transporter -
K1X80_RS11255 (K1X80_11255) 2473202..2473786 - 585 WP_057959159.1 TetR/AcrR family transcriptional regulator -
K1X80_RS11260 (K1X80_11260) 2473929..2475101 + 1173 WP_115127923.1 MFS transporter -
K1X80_RS11265 (K1X80_11265) 2475103..2475468 - 366 WP_057959161.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K1X80_RS11270 (K1X80_11270) 2475465..2475716 - 252 WP_220172894.1 type II toxin-antitoxin system HicA family toxin Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9494.13 Da        Isoelectric Point: 9.5640

>T211951 WP_220172894.1 NZ_CP080494:c2475716-2475465 [Pseudomonas sp. So3.2b]
VFKNEKLLAKLLNLQMAFTWPELVTLLGWLGYRQIEGAGSRVKFDIGDPSAMITLHKPHPGNELKYYIRRQIIEQLESGG
LIQ

Download         Length: 252 bp

>T211951 NZ_CP106883:c108556-108191 [Acidovorax sp. 5MLIR]
ATGAAATGGGATGTCGAGTACACAGATGACTTTGGCGACTGGTGGGCCGGCTTGACTGCAGAAGAGCAGGAATCGCTGGA
TACATCGGTACGTCTGTTGGAAGCGCGTGGGCCTACCCTGGGTTTTCCTCATAGCAGCGGAATCAATGGCTCACGGCACA
GCCATATGCGGGAATTGCGCACTCAGCATGATGGGCGCCCACTTCGAACCTTGTACGCGTTTGATCCCCGACGATCAGCT
ATTTTGTTGATTGGCGGGGACAAGACAGGAAACGACCGTTGGTATGACGTCCATGTTCCCATCGCCGACAGGCTTTACGA
CGAACATCTGGAGCAACTTCGAAAGGAAGGGCTGATCAATGGCTAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13353.20 Da        Isoelectric Point: 7.3512

>AT211951 WP_057959161.1 NZ_CP080494:c2475468-2475103 [Pseudomonas sp. So3.2b]
VSNQLKYKGYIGSIEASVEDNCLFGKLLFIRPLVSYEGQTVAQLEAAFREAVEDYLVTCQTLGQAPEKPCKGSFNVRVGH
DLHLAAALAATQKKVTLNDLTRQALNEFLRHHRTDSHPALG

Download         Length: 366 bp

>AT211951 NZ_CP106883:c108198-107872 [Acidovorax sp. 5MLIR]
ATGGCTAAGAAATTCTCTGAACTGCGGCAGCAAATGTCACCCGAGGCACAGGCCCGCGCCGAGGTTCAGGCACAGGCAAT
GCTTGCCGAGATGCCGCTCAATGAGCTGCGCCAAGCGCGTGGCCTGTCGCAAAAGATGCTGGCGGATGTACTCCGCGTTC
AGCAGCCTTCCATTGCCAAAATGGAGAGGCGCACGGATATGTACCTTTCCACGCTACGCAGTCACATCGAGGCGATGGGC
GGACAGCTGGAGATCGTGGCGCGCTTCCCGGACGGCGCGGTGAAGATCAATAACTTCGCCGATCTGAGCGGCAAAGCGGT
AGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References