Detailed information of TA system TA211950

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2009024..2009641
• Replicon: chromosome
• Accession: NZ_CP080494
• Organism: Pseudomonas sp. So3.2b

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: K1X80_RS09100
• Protein ID: WP_057438840.1
• Coordinates: 2009024..2009212 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: K1X80_RS09105
• Protein ID: WP_057958970.1
• Coordinates: 2009237..2009641 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K1X80_RS09070 (K1X80_09070)	2004130..2004972	+	843	WP_057438836.1	alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase PhnJ	-
K1X80_RS09075 (K1X80_09075)	2004933..2005742	+	810	WP_120734408.1	phosphonate C-P lyase system protein PhnK	-
K1X80_RS09080 (K1X80_09080)	2005739..2006461	+	723	WP_120732262.1	phosphonate C-P lyase system protein PhnL	-
K1X80_RS09085 (K1X80_09085)	2006451..2007596	+	1146	WP_057438838.1	alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase	-
K1X80_RS09090 (K1X80_09090)	2007596..2008162	+	567	WP_057444570.1	phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN	-
K1X80_RS09095 (K1X80_09095)	2008153..2008902	+	750	WP_057958969.1	phosphonate metabolism protein PhnP	-
K1X80_RS09100 (K1X80_09100)	2009024..2009212	+	189	WP_057438840.1	type II toxin-antitoxin system HicA family toxin	Toxin
K1X80_RS09105 (K1X80_09105)	2009237..2009641	+	405	WP_057958970.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
K1X80_RS09110 (K1X80_09110)	2010000..2011514	+	1515	WP_178112949.1	M10 family metallopeptidase C-terminal domain-containing protein	-
K1X80_RS09115 (K1X80_09115)	2011538..2012734	-	1197	WP_057438842.1	MFS transporter	-
K1X80_RS09120 (K1X80_09120)	2012965..2013969	-	1005	WP_057438843.1	sulfate ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7132.31 Da
• Isoelectric Point: 11.4962

>T211950 WP_057438840.1 NZ_CP080494:2009024-2009212 [Pseudomonas sp. So3.2b]
VQSRLLIKELQEAGWVLDRVMGSHHIFTHRYNPSTIPVPHPKKDLPLGTVRSIRQRAGLFSF

Nucleotide

• Length: 189 bp

>T211950 NZ_CP106883:c17682-17317 [Acidovorax sp. 5MLIR]
ATGAAATGGGATGTCGAGTACACAGATGACTTTGGCGACTGGTGGGCCGGCTTGACTGCAGAAGAGCAGGAATCGCTGGA
TACATCGGTACGTCTGTTGGAAGCGCGTGGGCCTACCCTGGGTTTTCCTCATAGCAGCGGAATCAATGGCTCACGGCACA
GCCATATGCGGGAATTGCGCACTCAGCATGATGGGCGCCCACTTCGAACCTTGTACGCGTTTGATCCCCGACGATCAGCT
ATTTTGTTGATTGGCGGGGACAAGACAGGAAACGACCGTTGGTATGACGTCCATGTTCCCATCGCCGACAGGCTTTACGA
CGAACATCTGGAGCAACTTCGAAAGGAAGGGCTGATCAATGGCTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14687.63 Da
• Isoelectric Point: 4.6098

>AT211950 WP_057958970.1 NZ_CP080494:2009237-2009641 [Pseudomonas sp. So3.2b]
MQYPICIEWGDDFTATGIQIPDIPGAVTAGDSFEEAYNAAVEVAHILLQELAGEGHAIPMPTSVATHHGNEEYAGMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHKVKSRSSFLADAALEKLVRS

Nucleotide

• Length: 405 bp

>AT211950 NZ_CP106883:c17324-16998 [Acidovorax sp. 5MLIR]
ATGGCTAAGAAATTCTCTGAACTGCGGCAGCAAATGTCACCCGAGGCACAGGCCCGCGCCGAGGTTCAGGCACAGGCAAT
GCTTGCCGAGATGCCGCTCAATGAGCTGCGCCAAGCGCGTGGCCTGTCGCAAAAGATGCTGGCGGATGTACTCCGCGTTC
AGCAGCCTTCCATTGCCAAAATGGAGAGGCGCACGGATATGTACCTTTCCACGCTACGCAGTCACATCGAGGCGATGGGC
GGACAGCTGGAGATCGTGGCGCGCTTCCCGGACGGCGCGGTGAAGATCAATAACTTCGCCGATCTGAGCGGCAAAGCGGT
AGCGTAG