Detailed information of TA system TA211949

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1710184..1710799
• Replicon: chromosome
• Accession: NZ_CP080494
• Organism: Pseudomonas sp. So3.2b

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: K1X80_RS07595
• Protein ID: WP_115127579.1
• Coordinates: 1710617..1710799 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: K1X80_RS07590
• Protein ID: WP_057439755.1
• Coordinates: 1710184..1710594 (-)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K1X80_RS07555 (K1X80_07555)	1705727..1706202	+	476	Protein_1494	hypothetical protein	-
K1X80_RS07560 (K1X80_07560)	1706207..1706695	-	489	WP_057958768.1	DMT family transporter	-
K1X80_RS07565 (K1X80_07565)	1706773..1707690	+	918	WP_233096829.1	LysR family transcriptional regulator	-
K1X80_RS07570 (K1X80_07570)	1707754..1708395	+	642	WP_057439757.1	LysE family translocator	-
K1X80_RS07575 (K1X80_07575)	1708514..1709041	+	528	WP_220172765.1	DUF4142 domain-containing protein	-
K1X80_RS07580 (K1X80_07580)	1709427..1709573	+	147	WP_164844853.1	hypothetical protein	-
K1X80_RS07585 (K1X80_07585)	1709587..1710087	-	501	WP_057958770.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-
K1X80_RS07590 (K1X80_07590)	1710184..1710594	-	411	WP_057439755.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
K1X80_RS07595 (K1X80_07595)	1710617..1710799	-	183	WP_115127579.1	type II toxin-antitoxin system HicA family toxin	Toxin
K1X80_RS07605 (K1X80_07605)	1711255..1712139	-	885	WP_120732097.1	alpha/beta hydrolase	-
K1X80_RS07610 (K1X80_07610)	1712435..1713127	-	693	WP_120732098.1	pseudouridine synthase	-
K1X80_RS07615 (K1X80_07615)	1713127..1713339	-	213	WP_057439751.1	cysteine-rich CWC family protein	-
K1X80_RS28090	1713557..1713916	+	360	WP_115127582.1	hypothetical protein	-
K1X80_RS07620 (K1X80_07620)	1714062..1714490	+	429	WP_169960411.1	DUF3757 domain-containing protein	-
K1X80_RS07625 (K1X80_07625)	1714513..1715625	-	1113	WP_057439749.1	enoyl-CoA hydratase/isomerase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6766.01 Da
• Isoelectric Point: 10.9646

>T211949 WP_115127579.1 NZ_CP080494:c1710799-1710617 [Pseudomonas sp. So3.2b]
VDSRYLIGHIVADGWYLVRVRGSHHHFKHPAKPGLVTIPHPKKHLLDKTAKSILKQALLA

Nucleotide

• Length: 183 bp

>T211949 NZ_CP106878:c2444348-2443998 [Fervidibacillus albus]
TTGATTGTTAAACGAGGCGACGTTTATTTTGCTGACCTTTCCCCTGTCGTTGGATCCGAGCAAGGTGGTGTTAGACCCGT
TCTTATTTTGCAAAATGACATCGGGAATCGGTTTAGCCCTACGGTAATCGTTGCCGCAATAACAGCCCAAATCCAAAAGG
CGAAATTGCCGACCCATGTGGAAATTGATGCAAAAAAATATGGGTTTGAAAGGGATTCGGTTATACTATTAGAACAAATT
CGAACGATTGATAAACAACGACTGACCGATAAAATTACTCATCTCGATGAGGACATGATGGAAAAAGTTGATGAAGCATT
GCGAATTAGTATGGGTTTAATCGAATTTTAA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14789.76 Da
• Isoelectric Point: 4.4077

>AT211949 WP_057439755.1 NZ_CP080494:c1710594-1710184 [Pseudomonas sp. So3.2b]
MLYPIAISTGDDDHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFELLAEEGAPIPSAQKVTLHAANPLYAGCTWAV
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQER

Nucleotide

• Length: 411 bp

>AT211949 NZ_CP106878:c2444635-2444354 [Fervidibacillus albus]
GTGTCCGAATCCAGTGTTACCCAAGAAATTTTAGTAAGCTTACCACAAAGCCTTTTGTCGGAAATTGATGGCTATGTGAA
ACAGGAAAATTGCAATCGGGACGAACTCATCTATCAAGCGACGAAAGCGTTTTTGCATGAGAAAAAAAAGAGACATATAC
GCGAATCGATGAGACGGGGATATATGGAAATGGCAAAAATCAACTTATCGATCGCGATGGAGGCCATCCATGCAGAATAT
GAGGCAGAACATACCGTTGAGAGACTAGTGAGTGGAGGATAA