Detailed information of TA system TA211948

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 492552..493207
• Replicon: chromosome
• Accession: NZ_CP080491
• Organism: Microbacterium sp. Se5.02b

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: K1X59_RS02475
• Protein ID: WP_183151734.1
• Coordinates: 492812..493207 (+)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: K1X59_RS02470
• Protein ID: WP_183151733.1
• Coordinates: 492552..492815 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K1X59_RS20615	487749..488129	+	381	WP_258567029.1	carboxyltransferase domain-containing protein	-
K1X59_RS20620	488057..488689	+	633	WP_258567030.1	carboxyltransferase domain-containing protein	-
K1X59_RS20625	488626..489036	+	411	Protein_502	allophanate hydrolase	-
K1X59_RS20630	489135..489326	+	192	WP_258567252.1	biotin-dependent carboxyltransferase family protein	-
K1X59_RS02460 (K1X59_02460)	489323..491035	+	1713	WP_183151731.1	biotin carboxylase N-terminal domain-containing protein	-
K1X59_RS02465 (K1X59_02465)	491111..492439	-	1329	WP_183151732.1	solute carrier family 23 protein	-
K1X59_RS02470 (K1X59_02470)	492552..492815	+	264	WP_183151733.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
K1X59_RS02475 (K1X59_02475)	492812..493207	+	396	WP_183151734.1	type II toxin-antitoxin system VapC family toxin	Toxin
K1X59_RS02480 (K1X59_02480)	493212..494090	-	879	WP_183151735.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
K1X59_RS02485 (K1X59_02485)	494168..494794	+	627	WP_220173881.1	PadR family transcriptional regulator	-
K1X59_RS02490 (K1X59_02490)	494791..496344	+	1554	WP_183151736.1	DHA2 family efflux MFS transporter permease subunit	-
K1X59_RS20635	496597..496935	+	339	WP_258567031.1	GNAT family N-acetyltransferase	-
K1X59_RS20640	497127..498170	-	1044	Protein_512	ROK family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-86)

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 14084.03 Da
• Isoelectric Point: 4.3953

>T211948 WP_183151734.1 NZ_CP080491:492812-493207 [Microbacterium sp. Se5.02b]
VIVDSSALVAILMEEAEAAEFSFRLATEDPMISAASLTECMIVLHGKAGEGMVRELDVLLRSAAVAVLPVDEAQARLAGN
AYARYGRGSGSPARLNYGDCFSYALAITRDEPLLFKGDDFVHTDVRRMESA

Nucleotide

• Length: 396 bp

>T211948 NZ_CP106877:2919064-2919414 [Fervidibacillus halotolerans]
TTGATTGTTAAAAGAGGCGACGTTTATTTTGCTGACCTTTCCCCTGTCGTTGGATCTGAGCAAGGAGGCGTTAGACCTGT
CCTTATTTTGCAAAATGACATCGGGAATCGGTTTAGCCCTACTGTAATCGTTGCCGCAATTACAGCCCAAATTCAAAAGG
CAAAACTGCCGACCCATGTGGAAATTGATGCGAAGAAATATGGATTTGAACGGGATTCGGTTATACTTTTGGAACAAATT
CGAACGATTGATAAACAACGATTAACAGACAAAATAACTCATCTCGATGATGATATGATGGAAAAAGTTGATGAATCATT
ACGAATTAGTTTAGGGTTAATCGAATTTTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9890.16 Da
• Isoelectric Point: 5.2473

>AT211948 WP_183151733.1 NZ_CP080491:492552-492815 [Microbacterium sp. Se5.02b]
MSLNIKNETTHELVRRLAALTGQSQTGAVEDAVRRRLAELEQSREEEIERKRAAIDAVVARARLIPRTGRTTEEIMDELY
DEAGMPR

Nucleotide

• Length: 264 bp

>AT211948 NZ_CP106877:2918777-2919058 [Fervidibacillus halotolerans]
GTGTCCGAATCTGGTGTAACGCAAGAAATATTAGTCAGCTTACCGCAAAGCCTTTTGTCGGAAATTGATGGCTATGTGAA
ACAGGAAAATTGCAATCGGGACGAACTGATCTATCAAGCGACAAAAGCTTTTTTGTATGAGAAAAAAAAGAGACATATTC
GCGAATCGATGAGACGGGGATATATGGAAATGGCAAAAATCAATTTATCGATCGCGATGGAAGCCATCCATGCGGAATAT
GAGGCAGAACATACTGTTGAGAGATTAGTGAGCGGGGGATAA