Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 33184..33752 Replicon plasmid p2
Accession NZ_CP080481
Organism Vibrio parahaemolyticus strain Vp2015094

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag K0819_RS24970 Protein ID WP_017449239.1
Coordinates 33411..33752 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag K0819_RS24965 Protein ID WP_017449238.1
Coordinates 33184..33414 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0819_RS24945 (K0819_24820) 28878..29783 - 906 WP_071653124.1 endonuclease/exonuclease/phosphatase family protein -
K0819_RS24950 (K0819_24825) 29977..30315 - 339 WP_129831085.1 hypothetical protein -
K0819_RS24955 (K0819_24830) 31630..32013 + 384 Protein_27 recombinase family protein -
K0819_RS24960 (K0819_24835) 32008..32610 - 603 WP_224067207.1 site-specific integrase -
K0819_RS24965 (K0819_24840) 33184..33414 + 231 WP_017449238.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
K0819_RS24970 (K0819_24845) 33411..33752 + 342 WP_017449239.1 endoribonuclease MazF Toxin
K0819_RS24975 (K0819_24850) 34055..34630 - 576 WP_017449240.1 hypothetical protein -
K0819_RS24980 34630..34857 - 228 WP_240433720.1 hypothetical protein -
K0819_RS24985 34920..35342 - 423 WP_017449242.1 hypothetical protein -
K0819_RS24990 (K0819_24860) 35602..35693 - 92 Protein_34 DUF3265 domain-containing protein -
K0819_RS24995 (K0819_24865) 36574..37650 - 1077 WP_017449243.1 replication initiation protein -
K0819_RS25000 (K0819_24870) 38035..38169 + 135 Protein_36 IS6 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..93083 93083


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-108)

Antitoxin

Antitoxin PemI-like

(1-75)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12189.68 Da        Isoelectric Point: 5.8124

>T211946 WP_017449239.1 NZ_CP080481:33411-33752 [Vibrio parahaemolyticus]
MTYAVPEKGDVVVMSFNPQSGHEQAGDSRPGLVISPKEFNQATGFALVCPITNQSKGYPFEVEITGSQKTTGVVLADQVK
SLDWRARRARVVDSVSNETLGTVRDYVTTIANG

Download         Length: 342 bp

>T211946 NZ_CP106874:4267876-4268175 [Shewanella xiamenensis]
ATGAATAATAAACGCTATAAACTGAGTAGGTTAGCTCAGGCTCACCTACTAAAGATTAAAGACTACGCCCTTCAACACTT
TTCTGAGTCGCAGTGGCACAAATACCAACAAAGCCTAATATCCGGCTTGCAAATGTTAGCCGATAACCCCGGATTAGGCA
GAAGCTGCAACGATATTTATCCCAACGGTTTCTACTTCCCTATAGGTAAACACACCGCCTACTTCACCAAAGAAGACGAC
TTTATCCTTATCGTTGCCCTGTTAGGTCAACCACAGCTACCCCAACATCATCTGAAATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8499.87 Da        Isoelectric Point: 6.4604

>AT211946 WP_017449238.1 NZ_CP080481:33184-33414 [Vibrio parahaemolyticus]
MSQTIAKWGHSAAVRIPSKVLKNMDMAVGDKVEVKVFNRQIIIEPAKPTLAQLLSQITDENRHDEVITETMGNELL

Download         Length: 231 bp

>AT211946 NZ_CP106874:4267625-4267867 [Shewanella xiamenensis]
ATGCAAACATTAACCGCCAATGACGCCAAACGAAATTTCGGTGAGTTGCTGCTAAACGCTCAACGTGAACCCATCAAGAT
CAGCAAAAACAGTAAAGATGCGGTTGTGGTCATGTCTATCCACGATTACGAACAGCTTGAGGCGATGAAAGCCGACTATC
TGAAGCACTGTTTCAACGCTGCTAAAGAAGACTTAGCGCAAGGTAATGTTGTTGATGGCGAAGATTTTCTTAACGCCCTG
TAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References