Detailed information of TA system TA211945

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 17645..18183
• Replicon: plasmid p2
• Accession: NZ_CP080481
• Organism: Vibrio parahaemolyticus strain Vp2015094

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: K0819_RS24925
• Protein ID: WP_029865329.1
• Coordinates: 17884..18183 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: K0819_RS24920
• Protein ID: WP_029865327.1
• Coordinates: 17645..17887 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K0819_RS24905 (K0819_24780)	12964..13593	-	630	WP_031501824.1	site-specific integrase	-
K0819_RS24910 (K0819_24785)	13593..14888	-	1296	WP_031501826.1	hypothetical protein	-
K0819_RS24915 (K0819_24790)	15876..17369	-	1494	WP_029865326.1	hypothetical protein	-
K0819_RS24920 (K0819_24795)	17645..17887	+	243	WP_029865327.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
K0819_RS24925 (K0819_24800)	17884..18183	+	300	WP_029865329.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..93083	93083

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11602.27 Da
• Isoelectric Point: 9.9225

>T211945 WP_029865329.1 NZ_CP080481:17884-18183 [Vibrio parahaemolyticus]
VKPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEVRDGYRKFPQGSHVIFYRQIGSQS
IEIIRILHKSMDVNPIFGA

Nucleotide

• Length: 300 bp

>T211945 NZ_CP106874:c3322274-3321834 [Shewanella xiamenensis]
GTGGCAGAGCTGCGCCATAGTTTTAGTGTAAAAGCCTCCTTTGACCAACGTCTCTCGTTGGTCGTATTTGTTTGTGTCTG
TAGCACTTCTTTACTTCTCTGGCCAGAAACGGATACCGCAGTACTACATGGACTGAGGGCTATACTCGCCGTCTTAATAT
TGGGATTCTTGTGCTCTCAGTTATGGCAACTGAGGAAATGGCATTGCCGTTTTGAACTTAATGGTCAAGGAGAAGGCTGG
CTATCAACGGGAGAGGCGTTTCACGTATTGCCCAGAACTTGGGTAACGCCGTTTATCTGCTTGGTTTACTATCAATCTGC
AAATAAGTTGCATCTCTTATCTCTATGGGCGGATATGTTTAGTGATACAGATTATCGCCACTTGTGCCGACTATTACTTA
AAGTTAAAACTCAGGCGGTGAGCCAACACGAACTACTTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8983.90 Da
• Isoelectric Point: 4.2213

>AT211945 WP_029865327.1 NZ_CP080481:17645-17887 [Vibrio parahaemolyticus]
MAKNTSITLGDHFDGFITNQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFINELDSEERK

Nucleotide

• Length: 243 bp

>AT211945 NZ_CP106874:c3322503-3322255 [Shewanella xiamenensis]
TTGGAGTTAATGAACATTGCACGGGTCCGTTGGGCATGTCGCCGCGGAATGCTCGAATTAGACGTTTTGTTCCAGCCCTT
CGTTGAGAATGTTTATCAGGATTTGTCTGATGAAGATAAAGCCCTGTTTATTCGTTTGCTCGAGTGTGAAGATCCTGAAT
TATTTGCATGGTTTATGGGTCATGAAGTTTGCCCTGATCCTGAGCTTGCCCGCATGGTAGTGCAAGTCCGTGGCAGAGCT
GCGCCATAG