Detailed information of TA system TA211944

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 1407440..1407999
• Replicon: chromosome
• Accession: NZ_CP080478
• Organism: Vibrio parahaemolyticus strain Vp2015094

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K0819_RS07090
• Protein ID: WP_140202137.1
• Coordinates: 1407440..1407718 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A347UR21
• Locus tag: K0819_RS07095
• Protein ID: WP_005398409.1
• Coordinates: 1407715..1407999 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K0819_RS07030 (K0819_06975)	1402645..1402992	+	348	WP_140202050.1	hypothetical protein	-
K0819_RS07035 (K0819_06980)	1403130..1403663	+	534	WP_140202051.1	cysteine hydrolase family protein	-
K0819_RS07040 (K0819_06985)	1403918..1404115	+	198	WP_140336902.1	hypothetical protein	-
K0819_RS07045	1404126..1404206	+	81	Protein_1312	DUF3265 domain-containing protein	-
K0819_RS07050 (K0819_06990)	1404294..1404647	+	354	WP_031819140.1	DUF6404 family protein	-
K0819_RS07055 (K0819_06995)	1404678..1404767	+	90	WP_072609598.1	DUF3265 domain-containing protein	-
K0819_RS07060 (K0819_07000)	1404797..1405177	+	381	WP_180805911.1	energy transducer TonB	-
K0819_RS07065 (K0819_07005)	1405672..1405761	+	90	WP_072828858.1	DUF3265 domain-containing protein	-
K0819_RS07070 (K0819_07010)	1405802..1406245	+	444	WP_140202134.1	GNAT family N-acetyltransferase	-
K0819_RS07075 (K0819_07020)	1406386..1406862	+	477	WP_140202176.1	GNAT family N-acetyltransferase	-
K0819_RS07080 (K0819_07025)	1406880..1406971	+	92	Protein_1319	DUF3265 domain-containing protein	-
K0819_RS07085 (K0819_07030)	1407229..1407411	+	183	WP_193234549.1	DUF3265 domain-containing protein	-
K0819_RS07090 (K0819_07035)	1407440..1407718	-	279	WP_140202137.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K0819_RS07095 (K0819_07040)	1407715..1407999	-	285	WP_005398409.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
K0819_RS07100 (K0819_07045)	1408197..1409111	+	915	WP_109883209.1	hypothetical protein	-
K0819_RS07105 (K0819_07050)	1409098..1410247	-	1150	Protein_1324	IS3 family transposase	-
K0819_RS07110 (K0819_07055)	1410370..1410615	+	246	WP_025506430.1	hypothetical protein	-
K0819_RS07115 (K0819_07060)	1410647..1411616	-	970	Protein_1326	IS30 family transposase	-
K0819_RS07120 (K0819_07065)	1411872..1412309	+	438	WP_017448875.1	DUF5675 family protein	-
K0819_RS07125 (K0819_07070)	1412313..1412807	+	495	WP_017448876.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1300951..1417771	116820
	-	inside	Integron	-	-	1301474..1409111	107637

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (1-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-69)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10863.52 Da
• Isoelectric Point: 4.3430

>T211944 WP_140202137.1 NZ_CP080478:c1407718-1407440 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRAM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T211944 NZ_CP106874:2032359-2033294 [Shewanella xiamenensis]
ATGAATAAGTCATCGATATACTACCAGCAAGTGACCTTGCTTATTCGGATGTTGCCGCTCGTCGCCCAAGAGAAGGTATT
TGCCCTAAAGGGCGGTACGGCTATCAACCTATTTGTACGCAACTTCCCACGCTTATCGGTCGATATCGATTTGGCTTATC
TTCCTTTGGAGCCAAGGGAACAAGCGCTACAAAGTGTGAAGGAAGCGCTTGGTCGTTTGACTGCGCAGATCAATCTACAA
CCGAACCTTAGTGCAGTATTTCAAGACAATAAATATGATGAGCTCAGGGTTGTCGTGACAAGTGATAGAGTCACAATAAA
AATTGAAGTCTCTCCTGTTGCGAGAGGTACGCTACACAAAGCGGTATTAATGCCAGTCGTTGAGTTAGTTGAAGAAGAAT
TTGGGTACGCAGAGATCCCCGTTGTAAGCCTGCCTGATCTATACGGTGGTAAGTTATGTGCAGCGATGGATAGACAGCAC
CCAAGGGATCTTTTCGATGTGAAAATGCTGCTGGCGGAAGAGGGGATCAGTCGAGAGATTTTAGTCGGCTTTCTCACTTA
TACACTTAGCCATCCAAGGCCCATTAATGAAGTGATGTCTCCACGCTGGAAACCGCTTGATGAAAGCTTTCAAACTGAAT
TCAATGGAATGACGACAAAGCCGATTAAACTCAATGAGCTGCTTTTAACTCGCTCAGAAATGCTAACAGCGTTGCAGCAT
CACTTTACTGCAAAAGATAGAGACTTTTTATTATCCTTTAAACAGGGTCAGCCTGATTGGTCATTGTTTGATGAACCGAG
CATTGCGGCACTACCTGCGGTGAGATGGAAGTTATTGAATATCCAAAACCTAGCGAAAAACAAATCCAAGCATCAAGAAC
AACTCATTAAACTGGCTGATGTATTGGAAACGTGGGTTGCAGGTCGGATACTGTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11069.40 Da
• Isoelectric Point: 9.2167

>AT211944 WP_005398409.1 NZ_CP080478:c1407999-1407715 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT211944 NZ_CP106874:2031578-2032366 [Shewanella xiamenensis]
ATGTCATCAAAAATAAACTGGCTGATTAATCATACGAGTCCTGGTGCGGTAGTGCTTCAGTCGTGGTTGACACAAAATGA
GATCAGCTCATCTTTGGTGAGAAAATATGTGCAGAGTGGTTGGTTGTACAAGATAAGTGCGGGGGTTTATGTTCGTCCTA
AGTCAACAGGCAAGTTACAGCCTCATTGGGTTGAAGCGCTCAAGGCTGTGAATGAGCAGCTAAAGCTTCCTGTTCACCTT
GCGGGAGTCAGTAGCCTAACGCATCAAGGGCTTAGTCATTATCTTCAACTAAGCAGCGAACAAGTTTGGGTTGGCTGTCA
AAGTAAGCAGGCGTTGCCAAAGTGGTTCCGCGAATTGGAGGAGCAAAATTGGCTTTTCTATACCAGTAGCAAGCTGACCC
AAACGTTGGAAAAAGACTTTATTACTATAGGGGTGAACAATAGGGAAGTTAAGGCAAGTTGTGCGGAGCTTGCCGCCTAT
GAGGTCGTCAATGCCATTGGCAAACATATCAGTTTTGAGCATGCCGCGGAGCTGTTTCAAGGGTTAGTGAATCTCAGCCC
ACGTAAAATACAGTCAATACTGAATCGAAGTGAAGCCGTACAAGCTAATCGCGTATTTCTCTTTTTAGGCCACTACTATC
AACACCAGTGGAGCAAAAGGCTAGATGAGCAGCAAATCACGCTTGGTGCGGGAAAGCGTCAGGTGGTGGCTCATGGCCGT
TACGATGGGCGGTATCAAATAACAGTGCCAGCATCGTTTATTAAGACAGAAGAAAATCAATATGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A347UR21