Detailed information of TA system TA211943

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1373674..1374202
• Replicon: chromosome
• Accession: NZ_CP080478
• Organism: Vibrio parahaemolyticus strain Vp2015094

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K0819_RS06790
• Protein ID: WP_046268373.1
• Coordinates: 1373674..1373964 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: K5UYY9
• Locus tag: K0819_RS06795
• Protein ID: WP_004730320.1
• Coordinates: 1373954..1374202 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K0819_RS06735 (K0819_06695)	1368864..1369313	+	450	WP_108695186.1	hypothetical protein	-
K0819_RS06740 (K0819_06700)	1369336..1369428	+	93	WP_079858411.1	DUF3265 domain-containing protein	-
K0819_RS06745 (K0819_06705)	1369510..1369767	+	258	WP_005448240.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
K0819_RS06750 (K0819_06710)	1369755..1370057	+	303	WP_140060746.1	type II toxin-antitoxin system RelE/ParE family toxin	-
K0819_RS06755 (K0819_06715)	1370093..1370185	+	93	WP_077673135.1	DUF3265 domain-containing protein	-
K0819_RS06760 (K0819_06720)	1370277..1371068	+	792	WP_140336879.1	hypothetical protein	-
K0819_RS06765	1371608..1371737	+	130	Protein_1256	DUF3265 domain-containing protein	-
K0819_RS06770	1371747..1371959	+	213	WP_081280266.1	hypothetical protein	-
K0819_RS06775 (K0819_06725)	1372245..1372904	+	660	WP_069505126.1	Bax inhibitor-1 family protein	-
K0819_RS06780 (K0819_06730)	1373039..1373548	+	510	WP_069505854.1	hypothetical protein	-
K0819_RS06785 (K0819_06735)	1373563..1373655	+	93	WP_079863683.1	DUF3265 domain-containing protein	-
K0819_RS06790 (K0819_06740)	1373674..1373964	-	291	WP_046268373.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K0819_RS06795 (K0819_06745)	1373954..1374202	-	249	WP_004730320.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
K0819_RS06800 (K0819_06750)	1374277..1374345	+	69	WP_074531725.1	DUF3265 domain-containing protein	-
K0819_RS06805 (K0819_06755)	1374904..1375230	+	327	WP_140336880.1	hypothetical protein	-
K0819_RS06810	1375729..1375806	+	78	WP_257974004.1	DUF3265 domain-containing protein	-
K0819_RS06815 (K0819_06770)	1376449..1376541	+	93	WP_075111373.1	DUF3265 domain-containing protein	-
K0819_RS06820 (K0819_06775)	1376568..1377737	+	1170	WP_069505414.1	hypothetical protein	-
K0819_RS06825 (K0819_06780)	1377710..1377844	+	135	WP_175424524.1	DUF3265 domain-containing protein	-
K0819_RS06830 (K0819_06785)	1377886..1378470	+	585	WP_140336918.1	hypothetical protein	-
K0819_RS06835 (K0819_06790)	1378488..1378577	+	90	WP_079748782.1	DUF3265 domain-containing protein	-
K0819_RS06840 (K0819_06795)	1378622..1378993	+	372	WP_180789782.1	hypothetical protein	-
K0819_RS06845 (K0819_06800)	1379021..1379110	+	90	Protein_1272	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1300951..1417771	116820
	-	inside	Integron	-	-	1301474..1409111	107637

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11275.28 Da
• Isoelectric Point: 10.5932

>T211943 WP_046268373.1 NZ_CP080478:c1373964-1373674 [Vibrio parahaemolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSEVYRKAMKRLDD

Nucleotide

• Length: 291 bp

>T211943 NZ_CP106874:22627-23697 [Shewanella xiamenensis]
GTGGAACGGAGCTACAAGAACTTAAACCTTGATCGTGCGGCGATCAAAAATTTGGTGGAGAGTTTTGCAACTGAGCACCA
ATTTACGATTAAGTCGATATCAGCAATACCTGGCACACAAAAAGGAACTAGGATTGTTTTTGGACGCACAGGCAACAAAT
TTGCGACTGTAAATGTGTTTTTCAACAAAGATGGCACTTCAACTATACAGTATCTGACTGGTGCGAATCATGATATTGGT
AAATTAATGACCGATCATCTTTATGGTTCAATAAATCCAGCTGAATTTGAACAAGTTAATATGGTTCTTGAGGGGTTCAC
CGAGTCTGCTATATTACCTGTTTTAGAGTTTGCAGCTGAAGAGTCTCACATCAAAGTTGTTGTGCATGCTCAAGACGAAC
ATAAAACTGTATGGAAAATACGTTCTGAAGAATATCAAGATGAACTTACTGTAACACTTCATATCAGAACGGATAAACTT
CAAATACAAGGTCGTCCACTATCATGCTATAGGGTTTTTATTTTCAACCTATCAGAACTACTTGATTTACAGGGATTAGA
AAAGGTTCTGATTAGACAAGAAGATGGCAATGCTGAAATCGTTCAGCAAGAAGTGGCTCGTTCTTACCTGCAGTCAGTCC
TCGGTGAATCTTACGAACGACTGCACTCTAATGTAGAAAAATTGCTCATTTCTGGTCTTTGTGTTAAGCTCGCGTCCCCC
AATTTGCCTGACTACTGTATGTTGCTTTATCCGGAGTTGCGTTCAATTGAGGGGGCTTTAAAGAGTAAATTCATGGCCTT
GGGTATCGAAGTTGGTAAGGACGGATTTGGTGATTTTTTTGTAAAAGACCAAGGTGTTCATGTTTTGAATGCTGACTGTG
CAGCTTTGTGTGCGAATGCTGAAGCCGCAAAAATCATTAGTGAAGCCTATACTTTCTACAATAGAGAACGTCATGGCTTA
TTCCATATGGAAGCACTTGTTGAAGCTAGTAGAATGATTAGCAACATTGCCCATCTCATGACAAAATCTACTCAAGCTTG
GGATCTCATCAAGAAATTATATAGTATATAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9109.39 Da
• Isoelectric Point: 3.9610

>AT211943 WP_004730320.1 NZ_CP080478:c1374202-1373954 [Vibrio parahaemolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLTIAKERESEESISVNID
DL

Nucleotide

• Length: 249 bp

>AT211943 NZ_CP106874:23699-24064 [Shewanella xiamenensis]
ATGTTTAATATTAGACGGTTAAGCTTAGATTTAAACTCAATAGCTATTGTTACGGCAATTGGCTACGAGAATCCTTTGTC
TTCATTATCTGAAATTGAACATGAATTAACTTGTTTGCTCGGTCAAGAGTTAAATGGTGAGGTAATTTTTGATCTCGTTT
GCTCAAATGGCTTGGAATGGAACCGTTTTCTGTCATTACAAGTCAAAAACGGTTCCTTCGACTATAATTCTGTTTCTATA
TTAGATAAAACAGATTTTATTTCTCAATTATTTGATGAACAAGCATATTTCTTAAGTAATAATTTACATTATCTTCAAGA
CTCTGTACTTACTTCTGACGAAATTCCTCGTGTTATCGGTGTTTAG

Structures

Antitoxin

• AlphaFold DB: A0A0L1LA33