Detailed information of TA system TA211942

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 1369510..1370057
• Replicon: chromosome
• Accession: NZ_CP080478
• Organism: Vibrio parahaemolyticus strain Vp2015094

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K0819_RS06750
• Protein ID: WP_140060746.1
• Coordinates: 1369755..1370057 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U3A269
• Locus tag: K0819_RS06745
• Protein ID: WP_005448240.1
• Coordinates: 1369510..1369767 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K0819_RS06685	1364893..1364970	+	78	Protein_1240	DUF3265 domain-containing protein	-
K0819_RS06690 (K0819_06655)	1365055..1365603	+	549	WP_025502402.1	hypothetical protein	-
K0819_RS06695 (K0819_06660)	1365770..1366168	+	399	WP_242444782.1	GNAT family N-acetyltransferase	-
K0819_RS06700	1366308..1366373	+	66	Protein_1243	DUF3265 domain-containing protein	-
K0819_RS06705 (K0819_06665)	1366928..1367272	+	345	WP_140202069.1	hypothetical protein	-
K0819_RS06710 (K0819_06670)	1367269..1367388	+	120	WP_154218809.1	DUF3265 domain-containing protein	-
K0819_RS06715 (K0819_06675)	1367416..1367880	+	465	WP_140202142.1	hypothetical protein	-
K0819_RS06720 (K0819_06680)	1367864..1367986	+	123	WP_225462250.1	DUF3265 domain-containing protein	-
K0819_RS06725 (K0819_06685)	1368047..1368418	+	372	WP_219588066.1	hypothetical protein	-
K0819_RS06730 (K0819_06690)	1368424..1368708	+	285	WP_219588067.1	hypothetical protein	-
K0819_RS06735 (K0819_06695)	1368864..1369313	+	450	WP_108695186.1	hypothetical protein	-
K0819_RS06740 (K0819_06700)	1369336..1369428	+	93	WP_079858411.1	DUF3265 domain-containing protein	-
K0819_RS06745 (K0819_06705)	1369510..1369767	+	258	WP_005448240.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
K0819_RS06750 (K0819_06710)	1369755..1370057	+	303	WP_140060746.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K0819_RS06755 (K0819_06715)	1370093..1370185	+	93	WP_077673135.1	DUF3265 domain-containing protein	-
K0819_RS06760 (K0819_06720)	1370277..1371068	+	792	WP_140336879.1	hypothetical protein	-
K0819_RS06765	1371608..1371737	+	130	Protein_1256	DUF3265 domain-containing protein	-
K0819_RS06770	1371747..1371959	+	213	WP_081280266.1	hypothetical protein	-
K0819_RS06775 (K0819_06725)	1372245..1372904	+	660	WP_069505126.1	Bax inhibitor-1 family protein	-
K0819_RS06780 (K0819_06730)	1373039..1373548	+	510	WP_069505854.1	hypothetical protein	-
K0819_RS06785 (K0819_06735)	1373563..1373655	+	93	WP_079863683.1	DUF3265 domain-containing protein	-
K0819_RS06790 (K0819_06740)	1373674..1373964	-	291	WP_046268373.1	type II toxin-antitoxin system RelE/ParE family toxin	-
K0819_RS06795 (K0819_06745)	1373954..1374202	-	249	WP_004730320.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
K0819_RS06800 (K0819_06750)	1374277..1374345	+	69	WP_074531725.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1300951..1417771	116820
	-	inside	Integron	-	-	1301474..1409111	107637

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11592.48 Da
• Isoelectric Point: 4.8951

>T211942 WP_140060746.1 NZ_CP080478:1369755-1370057 [Vibrio parahaemolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIVSKVERLEAFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Nucleotide

• Length: 303 bp

>T211942 NZ_CP106873:c2995624-2995253 [Mycobacterium avium subsp. paratuberculosis K-10]
ATGATTCTCGTTGACACGTCGGTATGGATCGATCATCTGCACGTCGCCGACAAGCGACTCATAGAGTTCCTGACCAACGA
CGCAATCGGTTGCCACCAAATGGTGATCGAGGAGTTGGCATTGGGTGCGATCAGGCGGCGCGCCGATCTATTGCGCCTGC
TGTCCAATCTTCGGGCGTTCCCGTTGTTGACGCATGCGGAGGTCCTTCATCTCGTCGAATGCCACCGCTTGTGGGGCCGC
GGACTGAGTGCGATCGACGTCCATCTTCTCGGGTCGGTTGCTCTGGTCGACGGTGCACGGCTATGGACCAGGGACAAGAA
TTTAAAAGCGGCGGGCTGGGACGTGGGTATCGCGATCGTCGACGAGCTCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9606.10 Da
• Isoelectric Point: 6.7269

>AT211942 WP_005448240.1 NZ_CP080478:1369510-1369767 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Nucleotide

• Length: 258 bp

>AT211942 NZ_CP106873:c2995817-2995611 [Mycobacterium avium subsp. paratuberculosis K-10]
ATGAGGACGACGGTGACGATTGACGACGCCTTATTGGCAGAGGCGGCCGAACTGACCGGGGTGACAGAGAGCGTGGCGCT
CCTCCGTCAGGGACTGCAGACACTCGTTCGGGTAGAGAGCGCCCGTCGGCTGGCGGCGCTCGGCGGCACGGATCGGAAGG
CATCGGTCGGCCCTCGCCGGAGGGCACCCGCCGATGATTCTCGTTGA

Structures

Antitoxin

• AlphaFold DB: A0A432DGX8