Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 214350..214876 Replicon plasmid pECC59-1
Accession NZ_CP080471
Organism Enterobacter hormaechei strain ECC59

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag K0823_RS23920 Protein ID WP_000323025.1
Coordinates 214350..214637 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag K0823_RS23925 Protein ID WP_000534858.1
Coordinates 214637..214876 (-) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0823_RS23885 (K0823_23885) 209920..210096 - 177 WP_001371930.1 hypothetical protein -
K0823_RS23890 (K0823_23890) 210607..211551 + 945 WP_000778029.1 DUF5417 domain-containing protein -
K0823_RS23895 (K0823_23895) 211647..212249 + 603 WP_001371889.1 hypothetical protein -
K0823_RS23900 (K0823_23900) 212309..212659 + 351 WP_000743059.1 hypothetical protein -
K0823_RS23905 (K0823_23905) 212706..212909 + 204 WP_001015183.1 hypothetical protein -
K0823_RS23910 (K0823_23910) 213191..213511 + 321 WP_000332796.1 hypothetical protein -
K0823_RS23915 (K0823_23915) 214124..214249 - 126 WP_229020258.1 DUF5431 family protein -
K0823_RS23920 (K0823_23920) 214350..214637 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
K0823_RS23925 (K0823_23925) 214637..214876 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
K0823_RS25500 214901..215005 + 105 Protein_225 protein YdfV -
K0823_RS23930 (K0823_23930) 215139..216062 - 924 WP_000167917.1 cation diffusion facilitator family transporter -
K0823_RS23935 (K0823_23935) 216262..216834 - 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
K0823_RS23940 (K0823_23940) 217310..218548 - 1239 WP_000219087.1 IS110-like element ISEsa2 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid ant(2'')-Ia / aadA2 / qacE / sul1 / qnrA1 / tet(A) / blaSHV-12 / dfrA16 - 1..272385 272385


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T211941 WP_000323025.1 NZ_CP080471:c214637-214350 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T211941 NZ_CP106873:c2215284-2214877 [Mycobacterium avium subsp. paratuberculosis K-10]
ATGACTGCAAGGCCGGCGGCCGGGGTGCTCGACACCTCGGTGTTCATCGCGTCCGAAAGCGGACGGCAGCTGGACGAGGC
GCGTATCCCCGACGAGGTAGCCACCACCGTCGTCACCCTTGCCGAACTTCACGCCGGCGTATTAGCCGCGACGACGTCCA
ACGTTCGGGCGCAACGCCTCGCAACGCTGGAATCGATAGCGGATATGGAAATGCTGCCAGTCGACGACGACGCGGTCCGC
ATGTGGGCAAGGTTGCGGATCCACCTAGCCGAGGCTGGACGGCGGATGCGGGCTAATGATCTGTGGATCGCGGCGATCGC
GGCATCGCGGGGACTGCCCGTTGTCACCCAGGATGACGACTTCGCCGCACTCGACGGCGCGGCGAACCTGGCGATTATTC
GGGTTTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT211941 WP_000534858.1 NZ_CP080471:c214876-214637 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT211941 NZ_CP106873:c2215541-2215281 [Mycobacterium avium subsp. paratuberculosis K-10]
ATGTCTGAAGTGGCGTCTCGCGAGCTGCGCAACGATACGGCGGGGGTACTGCGGCGCGTACGGGAAGGGGAGGACGTCAC
CATCACCATCAACGGCCGAGCCGTCGCGATGCTGACCCCGCTGCGGCCGCAGCGACGGCGGTGGCTGAGCAAGGCGGAGT
TGCTGTCGCGCTTGCGCCGCGCGCAAGCCGATCCCGGGCTACGCCAAGACCTCGCAACCCTTGCAGGCGACACCACTGAG
GACCTCGGTCCGATCCGATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References