Detailed information of TA system TA021194

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 734850..735321
• Replicon: chromosome
• Accession: NC_007146
• Organism: Haemophilus influenzae 86-028NP

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: Q4QMQ6
• Locus tag: NTHI_RS03755
• Protein ID: WP_005661452.1
• Coordinates: 735139..735321 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: NTHI_RS03750
• Protein ID: WP_005650837.1
• Coordinates: 734850..735146 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NTHI_RS03725 (NTHI0775)	730062..730814	-	753	WP_011272149.1	DUF3800 domain-containing protein	-
NTHI_RS03730 (NTHI0776)	730826..731632	-	807	WP_011272150.1	shikimate dehydrogenase	-
NTHI_RS03735 (NTHI0777)	731636..732187	-	552	WP_011272151.1	threonylcarbamoyl-AMP synthase	-
NTHI_RS03740 (NTHI0778)	732203..732739	-	537	WP_011272152.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
NTHI_RS03745 (NTHI0779)	732749..734665	-	1917	WP_011272153.1	ABC transporter ATP-binding protein	-
NTHI_RS03750 (NTHI0780)	734850..735146	-	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
NTHI_RS03755 (NTHI0781)	735139..735321	-	183	WP_005661452.1	shikimate 5-dehydrogenase	Toxin
NTHI_RS03760 (NTHI0782)	735591..738557	-	2967	WP_041174743.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7348.36 Da
• Isoelectric Point: 6.3057

>T21194 WP_005661452.1 NC_007146:c735321-735139 [Haemophilus influenzae 86-028NP]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVIQTTQQRLSELKERLKNE

Nucleotide

• Length: 183 bp

>T21194 NC_007146:c735321-735139 [Haemophilus influenzae 86-028NP]
ATGTACGAGATTCTCTTTTACAGAGACCAAAATGACATTGAGCCAGTGAAAGAATATCTGCTATCGCTGGCTCAAAATGA
AAGCAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAATCCAAACAACCCAACAACGCTTAAGTGAATTAA
AAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT21194 WP_005650837.1 NC_007146:c735146-734850 [Haemophilus influenzae 86-028NP]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT21194 NC_007146:c735146-734850 [Haemophilus influenzae 86-028NP]
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGCGAAAG
TAATTTACGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAACTTGAAACGTTGTTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA

Structures

Toxin

• AlphaFold DB: Q4QMQ6