Detailed information of TA system TA211939

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4526765..4527372
• Replicon: chromosome
• Accession: NZ_CP080470
• Organism: Enterobacter hormaechei strain ECC59

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A4Q4AAS0
• Locus tag: K0823_RS21825
• Protein ID: WP_057979982.1
• Coordinates: 4527187..4527372 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: K0823_RS21820
• Protein ID: WP_023315016.1
• Coordinates: 4526765..4527172 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K0823_RS21805 (K0823_21805)	4523509..4524762	+	1254	WP_015572749.1	valine--pyruvate transaminase	-
K0823_RS21810 (K0823_21810)	4524770..4525225	-	456	WP_045343649.1	4Fe-4S dicluster domain-containing protein	-
K0823_RS21815 (K0823_21815)	4525685..4526761	+	1077	WP_023323870.1	type I restriction enzyme HsdR N-terminal domain-containing protein	-
K0823_RS21820 (K0823_21820)	4526765..4527172	-	408	WP_023315016.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
K0823_RS21825 (K0823_21825)	4527187..4527372	-	186	WP_057979982.1	type II toxin-antitoxin system HicA family toxin	Toxin
K0823_RS21830 (K0823_21830)	4527622..4529160	-	1539	WP_006808612.1	aldehyde dehydrogenase AldB	-
K0823_RS21835 (K0823_21835)	4529327..4530211	+	885	WP_003860164.1	ROK family protein	-
K0823_RS21840 (K0823_21840)	4530215..4532053	-	1839	WP_220153430.1	selenocysteine-specific translation elongation factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6852.08 Da
• Isoelectric Point: 11.5191

>T211939 WP_057979982.1 NZ_CP080470:c4527372-4527187 [Enterobacter hormaechei]
VKSADIITVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Nucleotide

• Length: 186 bp

>T211939 NZ_CP106873:850934-851395 [Mycobacterium avium subsp. paratuberculosis K-10]
GTGGCCAAGCTTTCCGGATCCATCGATGTTCCGCTGCCCCCCGAGGTGGCCTGGCAGCACGCCTCCGACCTGTCCCGGTA
CAAGGAGTGGCTGACCATTCACCGGGTGTGGCGCAGCACCTTGCCCGACCAGATCGACAAGGGCACCGTCGTCGAGTCGA
TCGTCGAGGTCAAAGGCATGCTCAACCGGATCAAATGGACGGTGGTGCGCTACAAGCCACCGGAGGGGATGACGCTCAAC
GGCGACGGCGTCGGCGGGGTCAAGGTCAAGCTGATGGCCAAGGTGCAGCCCAAGGCGGACGGTTCCGTCGTCAGCTTCGA
CGTGCACCTCGGCGGTCCGGCGCTGTTCGGGCCCATCGGCATGATCGTCGCGGCCGCGCTGCGCGGCGACATCGACCAGT
CGCTGGAGAACTTCGTCACGGTGTTCGCCCGATCGGATCCGAGCACCAACGGTCATCGCTGA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 15205.20 Da
• Isoelectric Point: 4.5036

>AT211939 WP_023315016.1 NZ_CP080470:c4527172-4526765 [Enterobacter hormaechei]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEMLPLPGMVEAHLASHPEDFIGGQWL
LVDINMKQFEGRVERINITIPRRLLVKIDSFVSEHPQFTNRSAFLAEAARRVLPR

Nucleotide

• Length: 408 bp

>AT211939 NZ_CP106873:850742-850930 [Mycobacterium avium subsp. paratuberculosis K-10]
ATGGGATTCCTGGACAAGGCCAAGGACCTGTTGTCGCAGAACGCCGACAAGGTCGAGATGGCCATCGACAAGGCCGGCGA
GTTCGTCGACGAGAAGACCCAGGGCAAGTACTCCGACACCATCCACCAGGTGCAGGAGCAGGCCAAGAAGGCCACCGGCG
CCACCGAGACCGGCGACCAGCAGGGCTGA

Structures

Toxin

• AlphaFold DB: A0A4Q4AAS0