Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3741897..3742554 Replicon chromosome
Accession NZ_CP080470
Organism Enterobacter hormaechei strain ECC59

Toxin (Protein)


Gene name cptA Uniprot ID A0A837FG63
Locus tag K0823_RS17995 Protein ID WP_003863439.1
Coordinates 3741897..3742307 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag K0823_RS18000 Protein ID WP_003863437.1
Coordinates 3742288..3742554 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0823_RS17975 (K0823_17975) 3737895..3739628 - 1734 WP_126524546.1 single-stranded-DNA-specific exonuclease RecJ -
K0823_RS17980 (K0823_17980) 3739634..3740347 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K0823_RS17985 (K0823_17985) 3740376..3741272 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
K0823_RS17990 (K0823_17990) 3741374..3741895 + 522 WP_003863440.1 flavodoxin FldB -
K0823_RS17995 (K0823_17995) 3741897..3742307 - 411 WP_003863439.1 protein YgfX Toxin
K0823_RS18000 (K0823_18000) 3742288..3742554 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
K0823_RS18005 (K0823_18005) 3742849..3743829 + 981 WP_100154205.1 tRNA-modifying protein YgfZ -
K0823_RS18010 (K0823_18010) 3743915..3744574 - 660 WP_003863433.1 hemolysin III family protein -
K0823_RS18015 (K0823_18015) 3744841..3745572 + 732 WP_213781980.1 MurR/RpiR family transcriptional regulator -
K0823_RS18020 (K0823_18020) 3745689..3747122 + 1434 WP_220153326.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16339.24 Da        Isoelectric Point: 11.4775

>T211938 WP_003863439.1 NZ_CP080470:c3742307-3741897 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T211938 NZ_CP106870:c243568-243323 [Brucella sp. bbatCR03]
ATGAAGATCATCTGGGACGAACCGAAGCGACAGACCAACATTGCCAAGCACGGCTTGGACTTCGCTGACCTGCATTTCGA
ATTCTTCCTGTCGGCTAAGGTCTTCCCCACCAAGGCAGATCGCCTGATGGCAATCGGAGAATTCAACGGCCTGATTATCA
TCGCCGTCATTTTCAAGCCGGTTGGTTCGGAAGCCCTCTCCGTGATCTCCATGCGTCCAGCAAGCCAGAAGGAAAGGAAG
CTCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT211938 WP_003863437.1 NZ_CP080470:c3742554-3742288 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT211938 NZ_CP106870:c243323-243009 [Brucella sp. bbatCR03]
ATGGGTATCAAATTTTCCTCTAAGCGCCCTCTCACTCAGGAAGAAGAGGCAGAAATTCAGAAGATGATCGCAAGCGATCC
CGATGCACCGGAAGCCACCGATGAACAGCTTGCCAAGGCCAAGCCTTTCAAGGAAGCCTTTCCAGATATGGCCGCCAAGA
TGGAGAAGGCCATTCGAGGCCGGCCGCGCATCGACAATCCCAAGACGCCGGTTACTATCCGGCTCGATCAGGATGTAGTT
CAACGCTTCAAGGCCACCGGCAAAGGCTGGCAGGGCCGTATGAACGATGCCCTGCGCAAAGCTGTCGGGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FG63

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References