Detailed information of TA system TA211937

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA(toxin)
• Location: 3072911..3074694
• Replicon: chromosome
• Accession: NZ_CP080470
• Organism: Enterobacter hormaechei strain ECC59

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: K0823_RS14770
• Protein ID: WP_023314540.1
• Coordinates: 3072911..3074260 (+)
• Length: 450 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A837FFV9
• Locus tag: K0823_RS14775
• Protein ID: WP_003859317.1
• Coordinates: 3074257..3074694 (+)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K0823_RS14745 (K0823_14745)	3068734..3069669	-	936	WP_045343060.1	tRNA dihydrouridine(16) synthase DusC	-
K0823_RS14750 (K0823_14750)	3069838..3070233	+	396	WP_003859308.1	CidA/LrgA family protein	-
K0823_RS14755 (K0823_14755)	3070230..3070925	+	696	WP_003859310.1	CidB/LrgB family autolysis modulator	-
K0823_RS14760 (K0823_14760)	3071054..3071938	+	885	WP_003859312.1	cytidine deaminase	-
K0823_RS14765 (K0823_14765)	3072066..3072776	+	711	WP_003859314.1	outer membrane permeability protein SanA	-
K0823_RS14770 (K0823_14770)	3072911..3074260	+	1350	WP_023314540.1	HipA domain-containing protein	Toxin
K0823_RS14775 (K0823_14775)	3074257..3074694	+	438	WP_003859317.1	helix-turn-helix transcriptional regulator	Antitoxin
K0823_RS14780 (K0823_14780)	3074733..3075743	-	1011	WP_003859318.1	galactose/methyl galactoside ABC transporter permease MglC	-
K0823_RS14785 (K0823_14785)	3075759..3077279	-	1521	WP_003859320.1	galactose/methyl galactoside ABC transporter ATP-binding protein MglA	-
K0823_RS14790 (K0823_14790)	3077359..3078357	-	999	WP_017383382.1	galactose/glucose ABC transporter substrate-binding protein MglB	-
K0823_RS14795 (K0823_14795)	3078653..3079675	-	1023	WP_045337656.1	HTH-type transcriptional regulator GalS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-406)

Antitoxin

• Cro/C1-type helix-turn-helix domain (75-128)

Sequences

Toxin

Protein

• Length: 450 a.a.
• Molecular weight: 51137.78 Da
• Isoelectric Point: 4.6562

>T211937 WP_023314540.1 NZ_CP080470:3072911-3074260 [Enterobacter hormaechei]
METLTVQAYLNETWTDIALIKYPGSEKNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFRYIPDKLSRWGLL

Nucleotide

• Length: 1350 bp

>T211937 NZ_CP106869:c4584907-4584755 [Xanthomonas sp. AM6]
ATGAAGCGACTGCTCACCTTGATGATGCTGACCCTGTTCTGCGCGGGCATGCTGACTGGCTGCAACACCATGGCCGGTGC
CGGCAAAGACATGCAGAAGGCGGGCGAGAAGGTGGAAGACAAGGCGGGCGATTGCAGCGACGGCAAGTGCTGA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 16185.64 Da
• Isoelectric Point: 10.5154

>AT211937 WP_003859317.1 NZ_CP080470:3074257-3074694 [Enterobacter hormaechei]
MKTPNEAESELLQTLAQVRSVNKKRHHDEAEEPDKPSVVKRQRVTQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADVINKIFKPFGLQTGLVPVSKSLIASLFS

Nucleotide

• Length: 438 bp

>AT211937 NZ_CP106869:c4584669-4584535 [Xanthomonas sp. AM6]
ATGAAGCGTACTTTTGCGTGGATGCTGCTGGCGATGTTCTCGGTTGGCCTGCTGTCCGGCTGCAACACCGTTGCCGGTGC
CGGCAAGGATGTGCAGAGCGCCGGCGAGAAGGTCGAAGACGCCGCCAAGAACTGA

Structures

Antitoxin

• AlphaFold DB: A0A837FFV9