Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2261092..2261831 Replicon chromosome
Accession NZ_CP080470
Organism Enterobacter hormaechei strain ECC59

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag K0823_RS10835 Protein ID WP_220153839.1
Coordinates 2261092..2261577 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A927HKN6
Locus tag K0823_RS10840 Protein ID WP_045336276.1
Coordinates 2261565..2261831 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0823_RS10815 (K0823_10815) 2256175..2257467 + 1293 WP_045342950.1 glycosyl hydrolase family 28 protein -
K0823_RS25370 2257763..2258215 - 453 WP_250018378.1 hypothetical protein -
K0823_RS25375 2258294..2258710 - 417 WP_250018380.1 hypothetical protein -
K0823_RS10825 (K0823_10825) 2259526..2259885 - 360 WP_220153837.1 hypothetical protein -
K0823_RS10830 (K0823_10830) 2259903..2260841 - 939 WP_220153838.1 hypothetical protein -
K0823_RS10835 (K0823_10835) 2261092..2261577 - 486 WP_220153839.1 GNAT family N-acetyltransferase Toxin
K0823_RS10840 (K0823_10840) 2261565..2261831 - 267 WP_045336276.1 DUF1778 domain-containing protein Antitoxin
K0823_RS10845 (K0823_10845) 2261895..2262824 - 930 WP_126524894.1 LysR family transcriptional regulator -
K0823_RS10850 (K0823_10850) 2262954..2264342 + 1389 WP_063401776.1 MFS transporter -
K0823_RS10855 (K0823_10855) 2264364..2265359 - 996 WP_126524895.1 DUF2891 domain-containing protein -
K0823_RS10860 (K0823_10860) 2265369..2266355 - 987 WP_003857123.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17526.21 Da        Isoelectric Point: 9.9658

>T211928 WP_220153839.1 NZ_CP080470:c2261577-2261092 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLGEFVSGEAVLDEWLKQRGLKNQALGAARTFVICKTGTKQVAGFYSLGTGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T211928 NZ_CP106852:1962875-1963252 [Edwardsiella ictaluri]
ATGGGCAAGAACTTGCGAAAACATAACAATATTGTTATGTTTCACTCCATGAACTACACTATTGAGTACTACAGCGAAGA
GGTTCGGCTTGAGGTCGATCAGTTGCCAATGGGTATGCGGGTTCGATACCAGCATCTCGTTGAACGCATGGAAATCTACG
GTAGTAATCTCGGAGAACCACACACAAGCCCTTTTGGCGATGGGCTTTTTGAGCTTCGAATCAAAGGCAGTGATGGCATC
GCCCGCGTGTTTTACTGCACTCTTACCGGAAAACGTATCGTCATGCTGCACAGCTTCATCAAGAAAACCCAGAAGACGCC
AAGCGCTGAACGTAAGAAGGCTGAAACCAGAATGAAGGAGGTAAAACATGGCTGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10032.46 Da        Isoelectric Point: 4.4857

>AT211928 WP_045336276.1 NZ_CP080470:c2261831-2261565 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWGV

Download         Length: 267 bp

>AT211928 NZ_CP106852:1963242-1963550 [Edwardsiella ictaluri]
ATGGCTGGTAAACGCACCCCCCCCACGATGACGCATGATGAAATGGCTGCAAAATGGATGGAAGACCCGGCATTTAAAGC
AGAATACGATGCCATCGAAGAGGAATACGCCCTACTCGATGAAATGCTCGCAGCCCGCAAAAACGCGGGGCTGACCCAGG
CGCAGGTCGCCGAACGTATGGGAACCAAGGCTACAGCGATCACTCGCATGGAAAGTAATTTAGCCTCCGGCCAAAGCGGG
CCATCATTCGCCACGCTGAAAAAATTTGCACACGCGACCGGCAAGAAACTGCAGATCCGGTTTGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References