Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1091592..1092212 Replicon chromosome
Accession NZ_CP080470
Organism Enterobacter hormaechei strain ECC59

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag K0823_RS05205 Protein ID WP_015571250.1
Coordinates 1091592..1091810 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag K0823_RS05210 Protein ID WP_006809850.1
Coordinates 1091838..1092212 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0823_RS05175 (K0823_05175) 1087617..1087877 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
K0823_RS05180 (K0823_05180) 1087880..1088020 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
K0823_RS05185 (K0823_05185) 1088017..1088727 - 711 WP_022650493.1 GNAT family protein -
K0823_RS05190 (K0823_05190) 1088829..1090276 + 1448 Protein_1004 PLP-dependent aminotransferase family protein -
K0823_RS05195 (K0823_05195) 1090248..1090715 - 468 WP_022650495.1 YlaC family protein -
K0823_RS05200 (K0823_05200) 1090832..1091383 - 552 WP_022650496.1 maltose O-acetyltransferase -
K0823_RS05205 (K0823_05205) 1091592..1091810 - 219 WP_015571250.1 HHA domain-containing protein Toxin
K0823_RS05210 (K0823_05210) 1091838..1092212 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
K0823_RS05215 (K0823_05215) 1092722..1095868 - 3147 WP_022650497.1 multidrug efflux RND transporter permease subunit AcrB -
K0823_RS05220 (K0823_05220) 1095891..1097084 - 1194 WP_220153614.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T211926 WP_015571250.1 NZ_CP080470:c1091810-1091592 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T211926 NZ_CP106852:c1110018-1109815 [Edwardsiella ictaluri]
ATGACAAAAATCGATTATCTGATGAAGTTGCGTAAATGCACGACGCTGGATACTCTGGAACGCGTGATCGAAAAGAACAA
ATACGAACTTTCAGATGATGAGCTGGAAATTTTTTATTCTGCCGCAGATCATCGACTGGCTGAATTAACCATGAATAAAC
TATACGACAAAATTCCGGCAGAAGTTTGGCAATACGTCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT211926 WP_006809850.1 NZ_CP080470:c1092212-1091838 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT211926 NZ_CP106852:c1110407-1110039 [Edwardsiella ictaluri]
ATGGATGAGAACACTTCTTATCAGCATGACATCTCAGAGTTAAAATACCTGTGTGATTACCTGTATCATCAGGGAATAGA
TGTCTTGGGAGAAAGCAATCACGGCTGGGTCAGCGATCCGACGGCAGAAGTAAATCTACAGCTTAACGAGCTGATTGAGC
ATATTGCCAGCATCGCGCAATCATTTAAGATCAAATATCCGCGTCATTCGGATTTAGCCGAAATGCTGGATTATTATCTG
GATGAAACCTATGCCCTGTTTGGCACCTATAGCATAAGTGAAACGGCGCTCAGGCAATGGTTGCGTACCAAACGTCGGAT
GGCATACTGTCTGGCGCATGAAAAGCGCAACGCTGCCTTACATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References