Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 419538..420175 Replicon chromosome
Accession NC_007146
Organism Haemophilus influenzae 86-028NP

Toxin (Protein)


Gene name VapC1 Uniprot ID E4QWH2
Locus tag NTHI_RS02095 Protein ID WP_005649049.1
Coordinates 419771..420175 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID E4QWH3
Locus tag NTHI_RS02090 Protein ID WP_005649046.1
Coordinates 419538..419774 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTHI_RS02065 (NTHI0433) 414917..415657 - 741 WP_005649034.1 YebC/PmpR family DNA-binding transcriptional regulator -
NTHI_RS02070 (NTHI0434) 415669..416142 - 474 WP_011271985.1 dihydroneopterin triphosphate diphosphatase -
NTHI_RS02075 (NTHI0435) 416164..417930 - 1767 WP_011271986.1 aspartate--tRNA ligase -
NTHI_RS02080 (NTHI0436) 418149..418667 + 519 WP_005649040.1 isoprenylcysteine carboxyl methyltransferase family protein -
NTHI_RS02085 (NTHI0438) 418720..419445 + 726 WP_011271987.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
NTHI_RS02090 (NTHI0439) 419538..419774 + 237 WP_005649046.1 antitoxin Antitoxin
NTHI_RS02095 (NTHI0440) 419771..420175 + 405 WP_005649049.1 type II toxin-antitoxin system VapC family toxin Toxin
NTHI_RS02100 (NTHI0441) 420242..420649 + 408 WP_005688980.1 lactoylglutathione lyase -
NTHI_RS02105 (NTHI0442) 420723..421412 + 690 WP_011271988.1 ribonuclease T -
NTHI_RS02110 (NTHI0443) 421726..423078 + 1353 WP_005694344.1 Na+/H+ antiporter family protein -
NTHI_RS02115 (NTHI0444) 423111..423698 + 588 WP_005654063.1 primosomal replication protein -
NTHI_RS02125 (NTHI0446) 424049..424615 - 567 WP_005544066.1 elongation factor P -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15692.29 Da        Isoelectric Point: 8.9777

>T21192 WP_005649049.1 NC_007146:419771-420175 [Haemophilus influenzae 86-028NP]
MIYMLDTNIIIYLMKNRPKIIAERVSQLLPNDRLVMSFITYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Download         Length: 405 bp

>T21192 NC_007146:419771-420175 [Haemophilus influenzae 86-028NP]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTATTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATGAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCCTTTGGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTGAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGCGACCTATCGGAAATAATGATCTATGGATCGCTTGTCACGCATT
GAGTTTAAATGCCGTTCTTATTACACATAATGTAAAAGAATTTCAGCGAATTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9037.19 Da        Isoelectric Point: 4.2342

>AT21192 WP_005649046.1 NC_007146:419538-419774 [Haemophilus influenzae 86-028NP]
MLTKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Download         Length: 237 bp

>AT21192 NC_007146:419538-419774 [Haemophilus influenzae 86-028NP]
ATGCTTACTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGACGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E4QWH2

Antitoxin

Source ID Structure
AlphaFold DB E4QWH3

References