Detailed information of TA system TA021192

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 419538..420175
• Replicon: chromosome
• Accession: NC_007146
• Organism: Haemophilus influenzae 86-028NP

Toxin (Protein)

• Gene name: VapC1
• Uniprot ID: E4QWH2
• Locus tag: NTHI_RS02095
• Protein ID: WP_005649049.1
• Coordinates: 419771..420175 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: VapB1
• Uniprot ID: E4QWH3
• Locus tag: NTHI_RS02090
• Protein ID: WP_005649046.1
• Coordinates: 419538..419774 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NTHI_RS02065 (NTHI0433)	414917..415657	-	741	WP_005649034.1	YebC/PmpR family DNA-binding transcriptional regulator	-
NTHI_RS02070 (NTHI0434)	415669..416142	-	474	WP_011271985.1	dihydroneopterin triphosphate diphosphatase	-
NTHI_RS02075 (NTHI0435)	416164..417930	-	1767	WP_011271986.1	aspartate--tRNA ligase	-
NTHI_RS02080 (NTHI0436)	418149..418667	+	519	WP_005649040.1	isoprenylcysteine carboxyl methyltransferase family protein	-
NTHI_RS02085 (NTHI0438)	418720..419445	+	726	WP_011271987.1	carboxy-S-adenosyl-L-methionine synthase CmoA	-
NTHI_RS02090 (NTHI0439)	419538..419774	+	237	WP_005649046.1	antitoxin	Antitoxin
NTHI_RS02095 (NTHI0440)	419771..420175	+	405	WP_005649049.1	type II toxin-antitoxin system VapC family toxin	Toxin
NTHI_RS02100 (NTHI0441)	420242..420649	+	408	WP_005688980.1	lactoylglutathione lyase	-
NTHI_RS02105 (NTHI0442)	420723..421412	+	690	WP_011271988.1	ribonuclease T	-
NTHI_RS02110 (NTHI0443)	421726..423078	+	1353	WP_005694344.1	Na+/H+ antiporter family protein	-
NTHI_RS02115 (NTHI0444)	423111..423698	+	588	WP_005654063.1	primosomal replication protein	-
NTHI_RS02125 (NTHI0446)	424049..424615	-	567	WP_005544066.1	elongation factor P	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• SpoVT-AbrB domain (6-44)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15692.29 Da
• Isoelectric Point: 8.9777

>T21192 WP_005649049.1 NC_007146:419771-420175 [Haemophilus influenzae 86-028NP]
MIYMLDTNIIIYLMKNRPKIIAERVSQLLPNDRLVMSFITYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Nucleotide

• Length: 405 bp

>T21192 NC_007146:419771-420175 [Haemophilus influenzae 86-028NP]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTATTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATGAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCCTTTGGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTGAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGCGACCTATCGGAAATAATGATCTATGGATCGCTTGTCACGCATT
GAGTTTAAATGCCGTTCTTATTACACATAATGTAAAAGAATTTCAGCGAATTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9037.19 Da
• Isoelectric Point: 4.2342

>AT21192 WP_005649046.1 NC_007146:419538-419774 [Haemophilus influenzae 86-028NP]
MLTKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Nucleotide

• Length: 237 bp

>AT21192 NC_007146:419538-419774 [Haemophilus influenzae 86-028NP]
ATGCTTACTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGACGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA

Structures

Toxin

• AlphaFold DB: E4QWH2

Antitoxin

• AlphaFold DB: E4QWH3