Detailed information of TA system TA211903

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 231296..231855
• Replicon: chromosome
• Accession: NZ_CP080463
• Organism: Vibrio cholerae strain ICDC-VC702

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K1T74_RS15785
• Protein ID: WP_001897114.1
• Coordinates: 231296..231574 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9L991
• Locus tag: K1T74_RS15790
• Protein ID: WP_000381183.1
• Coordinates: 231571..231855 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K1T74_RS15750	226450..227322	+	873	Protein_274	DUF3800 domain-containing protein	-
K1T74_RS15755	227472..228071	+	600	WP_001891245.1	glutathione S-transferase N-terminal domain-containing protein	-
K1T74_RS15760	228227..228763	+	537	WP_000469484.1	GNAT family protein	-
K1T74_RS19920	228820..228891	+	72	Protein_277	iron transporter	-
K1T74_RS15765	229303..229572	+	270	WP_001114075.1	DUF4160 domain-containing protein	-
K1T74_RS15770	229566..230087	+	522	WP_000921691.1	DUF2442 domain-containing protein	-
K1T74_RS15775	230386..230511	+	126	WP_001905700.1	DUF645 family protein	-
K1T74_RS15780	230762..231157	+	396	WP_001000868.1	hypothetical protein	-
K1T74_RS15785	231296..231574	-	279	WP_001897114.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
K1T74_RS15790	231571..231855	-	285	WP_000381183.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
K1T74_RS15795	232049..232564	+	516	WP_000343779.1	GNAT family protein	-
K1T74_RS15800	232748..233161	+	414	WP_000049420.1	VOC family protein	-
K1T74_RS15805	233716..234894	+	1179	Protein_286	IS3-like element ISVch4 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	146834..233648	86814

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10820.53 Da
• Isoelectric Point: 4.6794

>T211903 WP_001897114.1 NZ_CP080463:c231574-231296 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Nucleotide

• Length: 279 bp

>T211903 NZ_CP106838:c505066-504746 [Klebsiella michiganensis]
ATGCACATTTCATCTGTACCAGCCACGGTGCCGGCTTCGTCACGCCTGTCGCCCATACAGGTCTGGCAGCAACTGTTAAC
GTATCTGCTGGAGCACCATTACGGCCTCACACTCAACGACACACCATTCCATGATGACACGGCTATCCAGGAACATATCG
AGGCGGGGATCACGCTTGCCGATGCAGTGAATTTTCTGGTGGATCGCTATGAACTGGTGCGCACTGATCGTAAGGGTTTC
AGTTGGCAGGAGCAGACGCCATTCCTGACCGCCACCGATATTCTCAGAGCAAGGCGTGCTACCGGGCTGATGAATACGTA
A

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10901.25 Da
• Isoelectric Point: 8.0775

>AT211903 WP_000381183.1 NZ_CP080463:c231855-231571 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Nucleotide

• Length: 285 bp

>AT211903 NZ_CP106838:c505426-505103 [Klebsiella michiganensis]
ATGCCATTAACACCACCTCATGAATGGGGGTTACAAAGCGATATCACCCCGCGATTTGGCGCAAGATTGGTTCAGGAAGG
TAACCGGCTGCATTACCTGGCTGACAGGGCTGGGTTGACGGGGAGCTTTAGCCCGGAGCAATTACAGAAACTGGATCAGG
CTTTCCCGCTGTTTATAGAACAACTGGAAAATTTGCTGCGCTCCGGTGAGATAAATCCACACCATCAACATCAGGTGACC
ATCCAGCTTGCGGGTTTAACCTGCATAGCTGATACCCGTGGTAGCTGCGGCTACGTTTACATTTCTATTTATCCAACCCA
GTAA

Structures

Antitoxin

• AlphaFold DB: A0A067BL33