Detailed information of TA system TA211902

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DhiAT/-
• Location: 229303..230087
• Replicon: chromosome
• Accession: NZ_CP080463
• Organism: Vibrio cholerae strain ICDC-VC702

Toxin (Protein)

• Gene name: dhiT
• Uniprot ID: A0A086SLD6
• Locus tag: K1T74_RS15765
• Protein ID: WP_001114075.1
• Coordinates: 229303..229572 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: dhiA
• Uniprot ID: Q9KM84
• Locus tag: K1T74_RS15770
• Protein ID: WP_000921691.1
• Coordinates: 229566..230087 (+)
• Length: 174 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K1T74_RS15730	224411..224698	+	288	WP_000221354.1	type II toxin-antitoxin system RelE/ParE family toxin	-
K1T74_RS15735	224908..225150	+	243	WP_000107462.1	hypothetical protein	-
K1T74_RS15740	225325..225714	+	390	WP_001081302.1	hypothetical protein	-
K1T74_RS15745	225850..226275	+	426	WP_002045007.1	GNAT family N-acetyltransferase	-
K1T74_RS15750	226450..227322	+	873	Protein_274	DUF3800 domain-containing protein	-
K1T74_RS15755	227472..228071	+	600	WP_001891245.1	glutathione S-transferase N-terminal domain-containing protein	-
K1T74_RS15760	228227..228763	+	537	WP_000469484.1	GNAT family protein	-
K1T74_RS19920	228820..228891	+	72	Protein_277	iron transporter	-
K1T74_RS15765	229303..229572	+	270	WP_001114075.1	DUF4160 domain-containing protein	Toxin
K1T74_RS15770	229566..230087	+	522	WP_000921691.1	DUF2442 domain-containing protein	Antitoxin
K1T74_RS15775	230386..230511	+	126	WP_001905700.1	DUF645 family protein	-
K1T74_RS15780	230762..231157	+	396	WP_001000868.1	hypothetical protein	-
K1T74_RS15785	231296..231574	-	279	WP_001897114.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
K1T74_RS15790	231571..231855	-	285	WP_000381183.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
K1T74_RS15795	232049..232564	+	516	WP_000343779.1	GNAT family protein	-
K1T74_RS15800	232748..233161	+	414	WP_000049420.1	VOC family protein	-
K1T74_RS15805	233716..234894	+	1179	Protein_286	IS3-like element ISVch4 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	146834..233648	86814

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF4160 (9-74)

Antitoxin

• Protein of unknown function DUF2442 (4-59)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10310.94 Da
• Isoelectric Point: 6.6303

>T211902 WP_001114075.1 NZ_CP080463:229303-229572 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Nucleotide

• Length: 270 bp

>T211902 NZ_CP106835:c6195-5929 [Staphylococcus epidermidis]
ATGAATAAGTACAATATAACTTTCACACCTACAGCTTTTGAAGATTATAAGTATTGGCAAACACAAGATAAAAAACTATT
AAAGAAAATTAATAGTTTGATTAAGAGTATTCAAAGAGATGGCATTTTAGAGGGTGAAGGCAAGGCCGAGCCTTTGAAAG
GTAATTTGAAAGGTTACTATAGTAGAAGAATAAATCACGAGCATAGATTAGTTTATACTATTAAAGACCCTAGTATTATA
ATCATTGCATGTAGATATCATTATTAA

Antitoxin

Protein

• Length: 174 a.a.
• Molecular weight: 19409.01 Da
• Isoelectric Point: 6.7342

>AT211902 WP_000921691.1 NZ_CP080463:229566-230087 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Nucleotide

• Length: 522 bp

>AT211902 NZ_CP106835:c6442-6188 [Staphylococcus epidermidis]
ATGACTGTTTTAACTTATTCAAACGCACGTAAGGATTTCCGAAAACTAATAGATAAAGTAAATGATGATAGTGATACAGT
AACTATTACAACTAATGACCGTAACGCTGTATTGATTAGTGAAGATGATTATAACTCAATTATGGAAACTCTCTACTTAC
AACAATCACCAGTCAATGCTAAACGCTTAGCTCAATCAATGGAAGAAGCTGAAAGAGTCAATACTGTAGAGGTAGATATA
ACAACTTATGAATAA

Structures

Toxin

• AlphaFold DB: A0A086SLD6

Antitoxin

• AlphaFold DB: Q9KM84