Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 229303..230087 Replicon chromosome
Accession NZ_CP080463
Organism Vibrio cholerae strain ICDC-VC702

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag K1T74_RS15765 Protein ID WP_001114075.1
Coordinates 229303..229572 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag K1T74_RS15770 Protein ID WP_000921691.1
Coordinates 229566..230087 (+) Length 174 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1T74_RS15730 224411..224698 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
K1T74_RS15735 224908..225150 + 243 WP_000107462.1 hypothetical protein -
K1T74_RS15740 225325..225714 + 390 WP_001081302.1 hypothetical protein -
K1T74_RS15745 225850..226275 + 426 WP_002045007.1 GNAT family N-acetyltransferase -
K1T74_RS15750 226450..227322 + 873 Protein_274 DUF3800 domain-containing protein -
K1T74_RS15755 227472..228071 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
K1T74_RS15760 228227..228763 + 537 WP_000469484.1 GNAT family protein -
K1T74_RS19920 228820..228891 + 72 Protein_277 iron transporter -
K1T74_RS15765 229303..229572 + 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
K1T74_RS15770 229566..230087 + 522 WP_000921691.1 DUF2442 domain-containing protein Antitoxin
K1T74_RS15775 230386..230511 + 126 WP_001905700.1 DUF645 family protein -
K1T74_RS15780 230762..231157 + 396 WP_001000868.1 hypothetical protein -
K1T74_RS15785 231296..231574 - 279 WP_001897114.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
K1T74_RS15790 231571..231855 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
K1T74_RS15795 232049..232564 + 516 WP_000343779.1 GNAT family protein -
K1T74_RS15800 232748..233161 + 414 WP_000049420.1 VOC family protein -
K1T74_RS15805 233716..234894 + 1179 Protein_286 IS3-like element ISVch4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 146834..233648 86814


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T211902 WP_001114075.1 NZ_CP080463:229303-229572 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T211902 NZ_CP106835:c6195-5929 [Staphylococcus epidermidis]
ATGAATAAGTACAATATAACTTTCACACCTACAGCTTTTGAAGATTATAAGTATTGGCAAACACAAGATAAAAAACTATT
AAAGAAAATTAATAGTTTGATTAAGAGTATTCAAAGAGATGGCATTTTAGAGGGTGAAGGCAAGGCCGAGCCTTTGAAAG
GTAATTTGAAAGGTTACTATAGTAGAAGAATAAATCACGAGCATAGATTAGTTTATACTATTAAAGACCCTAGTATTATA
ATCATTGCATGTAGATATCATTATTAA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT211902 WP_000921691.1 NZ_CP080463:229566-230087 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT211902 NZ_CP106835:c6442-6188 [Staphylococcus epidermidis]
ATGACTGTTTTAACTTATTCAAACGCACGTAAGGATTTCCGAAAACTAATAGATAAAGTAAATGATGATAGTGATACAGT
AACTATTACAACTAATGACCGTAACGCTGTATTGATTAGTGAAGATGATTATAACTCAATTATGGAAACTCTCTACTTAC
AACAATCACCAGTCAATGCTAAACGCTTAGCTCAATCAATGGAAGAAGCTGAAAGAGTCAATACTGTAGAGGTAGATATA
ACAACTTATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure
AlphaFold DB Q9KM84

References