Detailed information of TA system TA211900

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc(toxin)
• Location: 216908..217479
• Replicon: chromosome
• Accession: NZ_CP080463
• Organism: Vibrio cholerae strain ICDC-VC702

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: K1T74_RS15675
• Protein ID: WP_220106435.1
• Coordinates: 217078..217479 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: Q8GNG3
• Locus tag: K1T74_RS19910
• Protein ID: WP_001080654.1
• Coordinates: 216908..217078 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K1T74_RS15630	212230..212727	+	498	WP_000259905.1	GNAT family N-acetyltransferase	-
K1T74_RS19900	212783..212851	+	69	Protein_248	acetyltransferase	-
K1T74_RS15635	213022..213201	+	180	WP_025998961.1	DUF645 family protein	-
K1T74_RS15640	213452..213709	+	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
K1T74_RS15645	213697..213999	+	303	WP_131476981.1	type II toxin-antitoxin system RelE/ParE family toxin	-
K1T74_RS15650	214340..214492	+	153	WP_001893908.1	DUF645 family protein	-
K1T74_RS15655	214700..215047	+	348	WP_142542447.1	hypothetical protein	-
K1T74_RS15660	215166..215471	+	306	WP_258534313.1	hypothetical protein	-
K1T74_RS15665	215589..216249	+	661	Protein_255	Vat family streptogramin A O-acetyltransferase	-
K1T74_RS19905	216386..216784	+	399	Protein_256	GNAT family N-acetyltransferase	-
K1T74_RS19910	216908..217078	+	171	WP_001080654.1	hypothetical protein	Antitoxin
K1T74_RS15675	217078..217479	+	402	WP_220106435.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
K1T74_RS19915	217482..217592	+	111	WP_082798255.1	DUF3265 domain-containing protein	-
K1T74_RS15680	217620..218087	+	468	WP_025992851.1	GNAT family N-acetyltransferase	-
K1T74_RS15685	218288..218539	+	252	WP_088124792.1	TIGR03643 family protein	-
K1T74_RS15690	218703..219551	+	849	WP_108347920.1	hypothetical protein	-
K1T74_RS15695	219714..220352	+	639	WP_220106507.1	HD domain-containing protein	-
K1T74_RS15700	220518..221258	+	741	WP_172781623.1	PhzF family phenazine biosynthesis protein	-
K1T74_RS15705	221412..221951	+	540	WP_001898634.1	histidine phosphatase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	146834..233648	86814

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (1-132)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14624.71 Da
• Isoelectric Point: 4.0128

>T211900 WP_220106435.1 NZ_CP080463:217078-217479 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGSVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Nucleotide

• Length: 402 bp

>T211900 NZ_CP106834:1937872-1938060 [Staphylococcus epidermidis]
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCAGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAAAGAAGAACGAAAAGAATCTTATCTAGGCTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6287.35 Da
• Isoelectric Point: 10.7274

>AT211900 WP_001080654.1 NZ_CP080463:216908-217078 [Vibrio cholerae]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Nucleotide

• Length: 171 bp

>AT211900 NZ_CP106834:1937590-1937847 [Staphylococcus epidermidis]
ATGAAATTAAACAAAGCAAATATATTCAATTTGATATTCACCATTTTATTTTTTTCATTTAACATTCTCATAACCTATAA
CGCAAATATAGATTATAAGTTATGGTTAATACCTGGTTTAGCAATTTGTGGTTTTGCTCTTTTTTCAAGCTTGACCTTAG
TAATTATCTATAGTGATTTATTCAGTGAAATATTATTTTTTATCAACATTATCTTAGCACTGTATTACATTTATCCGATT
TTTTATGAATTTGTCTAA

Structures

Antitoxin

• AlphaFold DB: A0A1T4SJJ1