Detailed information of TA system TA211897

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 205190..205575
• Replicon: chromosome
• Accession: NZ_CP080463
• Organism: Vibrio cholerae strain ICDC-VC702

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: K1T74_RS15570
• Protein ID: WP_220106431.1
• Coordinates: 205309..205575 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: K1T74_RS15565
• Protein ID: WP_189018378.1
• Coordinates: 205190..205288 (+)
• Length: 33 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K1T74_RS15520	200590..200847	+	258	WP_220106429.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
K1T74_RS15525	200835..201136	+	302	Protein_225	type II toxin-antitoxin system RelE/ParE family toxin	-
K1T74_RS15530	201386..201811	+	426	WP_001898239.1	hypothetical protein	-
K1T74_RS15535	201973..202635	+	663	WP_202863405.1	hypothetical protein	-
K1T74_RS15540	202847..203671	+	825	WP_220106430.1	serine protease	-
K1T74_RS15545	203830..204288	+	459	WP_114755989.1	hypothetical protein	-
K1T74_RS15550	204328..204405	+	78	Protein_230	VOC family protein	-
K1T74_RS15555	204522..204821	-	300	WP_000802136.1	type II toxin-antitoxin system RelE/ParE family toxin	-
K1T74_RS15560	204818..205060	-	243	WP_001107719.1	type II toxin-antitoxin system ParD family antitoxin	-
K1T74_RS15565	205190..205288	+	99	WP_189018378.1	acetyltransferase	Antitoxin
K1T74_RS15570	205309..205575	+	267	WP_220106431.1	BrnT family toxin	Toxin
K1T74_RS15575	205562..205804	+	243	WP_033933251.1	hypothetical protein	-
K1T74_RS15580	205948..206715	+	768	WP_220106432.1	GNAT family N-acetyltransferase	-
K1T74_RS15585	206846..207232	+	387	WP_001015868.1	NUDIX hydrolase	-
K1T74_RS15590	207371..207823	+	453	WP_000383626.1	hypothetical protein	-
K1T74_RS19890	207892..207960	+	69	Protein_239	acetyltransferase	-
K1T74_RS15595	207973..208797	+	825	WP_220106433.1	hypothetical protein	-
K1T74_RS15600	208941..209486	+	546	WP_000494513.1	GNAT family protein	-
K1T74_RS15610	209626..209922	+	297	WP_000617997.1	Dabb family protein	-
K1T74_RS19895	209997..210062	+	66	Protein_243	acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	146834..233648	86814

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (6-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10062.32 Da
• Isoelectric Point: 7.3171

>T211897 WP_220106431.1 NZ_CP080463:205309-205575 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHAAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Nucleotide

• Length: 267 bp

>T211897 NZ_CP106834:799609-799971 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin

Protein

• Length: 33 a.a.
• Molecular weight: 3614.33 Da
• Isoelectric Point: 9.6590

>AT211897 WP_189018378.1 NZ_CP080463:205190-205288 [Vibrio cholerae]
VVTVVVFEFGVMRCQPLRRALAVINKQSLPNE

Nucleotide

• Length: 99 bp

>AT211897 NZ_CP106834:799442-799612 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTCCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA