Detailed information of TA system TA211896

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 204522..205060
• Replicon: chromosome
• Accession: NZ_CP080463
• Organism: Vibrio cholerae strain ICDC-VC702

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q9KMJ0
• Locus tag: K1T74_RS15555
• Protein ID: WP_000802136.1
• Coordinates: 204522..204821 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: P58093
• Locus tag: K1T74_RS15560
• Protein ID: WP_001107719.1
• Coordinates: 204818..205060 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K1T74_RS15520	200590..200847	+	258	WP_220106429.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
K1T74_RS15525	200835..201136	+	302	Protein_225	type II toxin-antitoxin system RelE/ParE family toxin	-
K1T74_RS15530	201386..201811	+	426	WP_001898239.1	hypothetical protein	-
K1T74_RS15535	201973..202635	+	663	WP_202863405.1	hypothetical protein	-
K1T74_RS15540	202847..203671	+	825	WP_220106430.1	serine protease	-
K1T74_RS15545	203830..204288	+	459	WP_114755989.1	hypothetical protein	-
K1T74_RS15550	204328..204405	+	78	Protein_230	VOC family protein	-
K1T74_RS15555	204522..204821	-	300	WP_000802136.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K1T74_RS15560	204818..205060	-	243	WP_001107719.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
K1T74_RS15565	205190..205288	+	99	WP_189018378.1	acetyltransferase	-
K1T74_RS15570	205309..205575	+	267	WP_220106431.1	BrnT family toxin	-
K1T74_RS15575	205562..205804	+	243	WP_033933251.1	hypothetical protein	-
K1T74_RS15580	205948..206715	+	768	WP_220106432.1	GNAT family N-acetyltransferase	-
K1T74_RS15585	206846..207232	+	387	WP_001015868.1	NUDIX hydrolase	-
K1T74_RS15590	207371..207823	+	453	WP_000383626.1	hypothetical protein	-
K1T74_RS19890	207892..207960	+	69	Protein_239	acetyltransferase	-
K1T74_RS15595	207973..208797	+	825	WP_220106433.1	hypothetical protein	-
K1T74_RS15600	208941..209486	+	546	WP_000494513.1	GNAT family protein	-
K1T74_RS15610	209626..209922	+	297	WP_000617997.1	Dabb family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	146834..233648	86814

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11589.29 Da
• Isoelectric Point: 9.9232

>T211896 WP_000802136.1 NZ_CP080463:c204821-204522 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Nucleotide

• Length: 300 bp

>T211896 NZ_CP106834:788557-788766 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8964.84 Da
• Isoelectric Point: 4.1677

>AT211896 WP_001107719.1 NZ_CP080463:c205060-204818 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Nucleotide

• Length: 243 bp

>AT211896 NZ_CP106834:788257-788550 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Structures

Toxin

• PDB: 7R5A

Antitoxin

• AlphaFold DB: A0A151JFU4