Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 204522..205060 Replicon chromosome
Accession NZ_CP080463
Organism Vibrio cholerae strain ICDC-VC702

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag K1T74_RS15555 Protein ID WP_000802136.1
Coordinates 204522..204821 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag K1T74_RS15560 Protein ID WP_001107719.1
Coordinates 204818..205060 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1T74_RS15520 200590..200847 + 258 WP_220106429.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K1T74_RS15525 200835..201136 + 302 Protein_225 type II toxin-antitoxin system RelE/ParE family toxin -
K1T74_RS15530 201386..201811 + 426 WP_001898239.1 hypothetical protein -
K1T74_RS15535 201973..202635 + 663 WP_202863405.1 hypothetical protein -
K1T74_RS15540 202847..203671 + 825 WP_220106430.1 serine protease -
K1T74_RS15545 203830..204288 + 459 WP_114755989.1 hypothetical protein -
K1T74_RS15550 204328..204405 + 78 Protein_230 VOC family protein -
K1T74_RS15555 204522..204821 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K1T74_RS15560 204818..205060 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
K1T74_RS15565 205190..205288 + 99 WP_189018378.1 acetyltransferase -
K1T74_RS15570 205309..205575 + 267 WP_220106431.1 BrnT family toxin -
K1T74_RS15575 205562..205804 + 243 WP_033933251.1 hypothetical protein -
K1T74_RS15580 205948..206715 + 768 WP_220106432.1 GNAT family N-acetyltransferase -
K1T74_RS15585 206846..207232 + 387 WP_001015868.1 NUDIX hydrolase -
K1T74_RS15590 207371..207823 + 453 WP_000383626.1 hypothetical protein -
K1T74_RS19890 207892..207960 + 69 Protein_239 acetyltransferase -
K1T74_RS15595 207973..208797 + 825 WP_220106433.1 hypothetical protein -
K1T74_RS15600 208941..209486 + 546 WP_000494513.1 GNAT family protein -
K1T74_RS15610 209626..209922 + 297 WP_000617997.1 Dabb family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 146834..233648 86814


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T211896 WP_000802136.1 NZ_CP080463:c204821-204522 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T211896 NZ_CP106834:788557-788766 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT211896 WP_001107719.1 NZ_CP080463:c205060-204818 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT211896 NZ_CP106834:788257-788550 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
PDB 7R5A
PDB 7B22
AlphaFold DB A0A151JFU4

References