Detailed information of TA system TA211895

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 198135..198694
• Replicon: chromosome
• Accession: NZ_CP080463
• Organism: Vibrio cholerae strain ICDC-VC702

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K1T74_RS15500
• Protein ID: WP_148553813.1
• Coordinates: 198135..198413 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: K1T74_RS15505
• Protein ID: WP_002044806.1
• Coordinates: 198410..198694 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K1T74_RS15460	193540..193821	+	282	WP_176398545.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
K1T74_RS15465	193818..194105	+	288	WP_199352274.1	type II toxin-antitoxin system RelE/ParE family toxin	-
K1T74_RS15470	194267..194653	+	387	WP_000703159.1	VOC family protein	-
K1T74_RS15475	194798..195295	+	498	WP_220106427.1	GNAT family N-acetyltransferase	-
K1T74_RS15480	195459..196229	+	771	WP_057569086.1	alpha/beta hydrolase	-
K1T74_RS15485	196397..197320	+	924	WP_258534312.1	DUF4263 domain-containing protein	-
K1T74_RS19875	197424..197519	+	96	WP_114762990.1	hypothetical protein	-
K1T74_RS15495	197571..197981	+	411	WP_220106428.1	hypothetical protein	-
K1T74_RS15500	198135..198413	-	279	WP_148553813.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K1T74_RS15505	198410..198694	-	285	WP_002044806.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
K1T74_RS19880	198844..198923	+	80	Protein_221	acetyltransferase	-
K1T74_RS19885	199047..199199	+	153	Protein_222	DUF645 family protein	-
K1T74_RS15515	199475..200392	+	918	WP_000186333.1	alpha/beta hydrolase	-
K1T74_RS15520	200590..200847	+	258	WP_220106429.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
K1T74_RS15525	200835..201136	+	302	Protein_225	type II toxin-antitoxin system RelE/ParE family toxin	-
K1T74_RS15530	201386..201811	+	426	WP_001898239.1	hypothetical protein	-
K1T74_RS15535	201973..202635	+	663	WP_202863405.1	hypothetical protein	-
K1T74_RS15540	202847..203671	+	825	WP_220106430.1	serine protease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	146834..233648	86814

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10810.51 Da
• Isoelectric Point: 4.6794

>T211895 WP_148553813.1 NZ_CP080463:c198413-198135 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIASYWVDGSKIRIM
RVLHQKQKFPND

Nucleotide

• Length: 279 bp

>T211895 NZ_CP106831:c1215146-1214847 [Empedobacter falsenii]
ATGAATTACAAAATCAGTAAGCAAGCTGAAATTGATTTAGAAAATATTTGGCTTTATACTTTTGAAGAATGGTCTTTGGA
ACAAGCTGATTATTATCTTGATTTAATAATAGATGAAATTGAATATATTTCTGAAAACCCAAAAACAGGGAAAGATTACA
ATGATGTTAGAAAAGGATATTTTAGATCTAGAGTAAAATCACATTTCATTTTTTACAGAATTAATATAAAGGAAGAAATT
GTGGAAATTATTAGAATTTTACATCAACAAATGGATATTGAATCTCATATTAATGAATAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10929.30 Da
• Isoelectric Point: 8.0775

>AT211895 WP_002044806.1 NZ_CP080463:c198694-198410 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHV

Nucleotide

• Length: 285 bp

>AT211895 NZ_CP106831:c1215394-1215146 [Empedobacter falsenii]
ATGGCAAAAAATACTTCGATTTTATTGGGCGATTATTTCGACAATTTTATCAATTCACAAATAAAAACTGGAAAATATTC
TTCGGCAAGTGAAGTTGTAAGAGCTGCTTTAAGAATGTTTGAGCATGAAGAAACAAAGAAAACTGAATTAATTAAAGAAT
TAAAAAAAGGAGAAAAATCTGGTTTTTCTTCAGATTTTAATCGAGAATCATTCAAACAAAATTTACATCAAAAATGTTCT
GCTAAATAA