Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 193540..194105 Replicon chromosome
Accession NZ_CP080463
Organism Vibrio cholerae strain ICDC-VC702

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag K1T74_RS15465 Protein ID WP_199352274.1
Coordinates 193818..194105 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag K1T74_RS15460 Protein ID WP_176398545.1
Coordinates 193540..193821 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1T74_RS15420 188821..189132 + 312 WP_000623749.1 hypothetical protein -
K1T74_RS19865 189228..189902 + 675 WP_258534315.1 SLATT domain-containing protein -
K1T74_RS15430 190060..190584 + 525 WP_220106424.1 GNAT family protein -
K1T74_RS15435 190758..190994 - 237 WP_000772130.1 RNA-binding protein -
K1T74_RS15440 191246..191671 + 426 WP_220106425.1 GNAT family N-acetyltransferase -
K1T74_RS15445 191858..192166 + 309 WP_220106426.1 hypothetical protein -
K1T74_RS15450 192316..192804 + 489 WP_002051091.1 GNAT family N-acetyltransferase -
K1T74_RS19870 192861..192932 + 72 Protein_209 acetyltransferase -
K1T74_RS15455 193098..193279 + 182 Protein_210 DUF645 family protein -
K1T74_RS15460 193540..193821 + 282 WP_176398545.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K1T74_RS15465 193818..194105 + 288 WP_199352274.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K1T74_RS15470 194267..194653 + 387 WP_000703159.1 VOC family protein -
K1T74_RS15475 194798..195295 + 498 WP_220106427.1 GNAT family N-acetyltransferase -
K1T74_RS15480 195459..196229 + 771 WP_057569086.1 alpha/beta hydrolase -
K1T74_RS15485 196397..197320 + 924 WP_258534312.1 DUF4263 domain-containing protein -
K1T74_RS19875 197424..197519 + 96 WP_114762990.1 hypothetical protein -
K1T74_RS15495 197571..197981 + 411 WP_220106428.1 hypothetical protein -
K1T74_RS15500 198135..198413 - 279 WP_148553813.1 type II toxin-antitoxin system RelE/ParE family toxin -
K1T74_RS15505 198410..198694 - 285 WP_002044806.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
K1T74_RS19880 198844..198923 + 80 Protein_221 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 146834..233648 86814


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11056.81 Da        Isoelectric Point: 6.4790

>T211894 WP_199352274.1 NZ_CP080463:193818-194105 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVREMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV

Download         Length: 288 bp

>T211894 NZ_CP106831:38674-38931 [Empedobacter falsenii]
ATGAAATACATATTCGTAGATGAATCTTGGGAAGATTATTTGTTTTGGCAAAAAACAGACAAAAAAAAAGTCAAACGAAT
CAATGATCTATTAAAAGACATCTCTAGAACACCTTTTACAGGAATAAGGAAGCCAGAGCCTTTAAAACATAAGTATTCGG
GGTTTTGGTCACGAAGAATAGATGATGAACATCGTTTAATATATAAATATGAAGACGGACAAATACTTATTGCTAAATGC
CGTTTTCATTATGATTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10346.96 Da        Isoelectric Point: 5.1548

>AT211894 WP_176398545.1 NZ_CP080463:193540-193821 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSLVLGRIIK

Download         Length: 282 bp

>AT211894 NZ_CP106831:38419-38673 [Empedobacter falsenii]
ATGTTAATAGCAAGTGTTTCAGATTTCAGAAAAGATTTAAAATCTTATTTAGATAGAGTTTCAAAAAATTTTGAAACTTT
AATCATCAACAGAGGAAAAGATTCTGGTATTGTTGTAATGTCTCTTGAAGAATACAATTCATTAATGGCGACAAACTATG
AATTATCTTCTCGTATCAACGAATCAAGACTTGATTCAGCCATTGAAAAATTAAAAAGTAATCAATCTTTCGAAAAAGAA
TTAATCGAAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References