Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 193540..194105 | Replicon | chromosome |
| Accession | NZ_CP080463 | ||
| Organism | Vibrio cholerae strain ICDC-VC702 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | K1T74_RS15465 | Protein ID | WP_199352274.1 |
| Coordinates | 193818..194105 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | K1T74_RS15460 | Protein ID | WP_176398545.1 |
| Coordinates | 193540..193821 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K1T74_RS15420 | 188821..189132 | + | 312 | WP_000623749.1 | hypothetical protein | - |
| K1T74_RS19865 | 189228..189902 | + | 675 | WP_258534315.1 | SLATT domain-containing protein | - |
| K1T74_RS15430 | 190060..190584 | + | 525 | WP_220106424.1 | GNAT family protein | - |
| K1T74_RS15435 | 190758..190994 | - | 237 | WP_000772130.1 | RNA-binding protein | - |
| K1T74_RS15440 | 191246..191671 | + | 426 | WP_220106425.1 | GNAT family N-acetyltransferase | - |
| K1T74_RS15445 | 191858..192166 | + | 309 | WP_220106426.1 | hypothetical protein | - |
| K1T74_RS15450 | 192316..192804 | + | 489 | WP_002051091.1 | GNAT family N-acetyltransferase | - |
| K1T74_RS19870 | 192861..192932 | + | 72 | Protein_209 | acetyltransferase | - |
| K1T74_RS15455 | 193098..193279 | + | 182 | Protein_210 | DUF645 family protein | - |
| K1T74_RS15460 | 193540..193821 | + | 282 | WP_176398545.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| K1T74_RS15465 | 193818..194105 | + | 288 | WP_199352274.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K1T74_RS15470 | 194267..194653 | + | 387 | WP_000703159.1 | VOC family protein | - |
| K1T74_RS15475 | 194798..195295 | + | 498 | WP_220106427.1 | GNAT family N-acetyltransferase | - |
| K1T74_RS15480 | 195459..196229 | + | 771 | WP_057569086.1 | alpha/beta hydrolase | - |
| K1T74_RS15485 | 196397..197320 | + | 924 | WP_258534312.1 | DUF4263 domain-containing protein | - |
| K1T74_RS19875 | 197424..197519 | + | 96 | WP_114762990.1 | hypothetical protein | - |
| K1T74_RS15495 | 197571..197981 | + | 411 | WP_220106428.1 | hypothetical protein | - |
| K1T74_RS15500 | 198135..198413 | - | 279 | WP_148553813.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| K1T74_RS15505 | 198410..198694 | - | 285 | WP_002044806.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| K1T74_RS19880 | 198844..198923 | + | 80 | Protein_221 | acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 146834..233648 | 86814 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11056.81 Da Isoelectric Point: 6.4790
>T211894 WP_199352274.1 NZ_CP080463:193818-194105 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVREMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVREMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV
Download Length: 288 bp
>T211894 NZ_CP106831:38674-38931 [Empedobacter falsenii]
ATGAAATACATATTCGTAGATGAATCTTGGGAAGATTATTTGTTTTGGCAAAAAACAGACAAAAAAAAAGTCAAACGAAT
CAATGATCTATTAAAAGACATCTCTAGAACACCTTTTACAGGAATAAGGAAGCCAGAGCCTTTAAAACATAAGTATTCGG
GGTTTTGGTCACGAAGAATAGATGATGAACATCGTTTAATATATAAATATGAAGACGGACAAATACTTATTGCTAAATGC
CGTTTTCATTATGATTAA
ATGAAATACATATTCGTAGATGAATCTTGGGAAGATTATTTGTTTTGGCAAAAAACAGACAAAAAAAAAGTCAAACGAAT
CAATGATCTATTAAAAGACATCTCTAGAACACCTTTTACAGGAATAAGGAAGCCAGAGCCTTTAAAACATAAGTATTCGG
GGTTTTGGTCACGAAGAATAGATGATGAACATCGTTTAATATATAAATATGAAGACGGACAAATACTTATTGCTAAATGC
CGTTTTCATTATGATTAA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10346.96 Da Isoelectric Point: 5.1548
>AT211894 WP_176398545.1 NZ_CP080463:193540-193821 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSLVLGRIIK
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSLVLGRIIK
Download Length: 282 bp
>AT211894 NZ_CP106831:38419-38673 [Empedobacter falsenii]
ATGTTAATAGCAAGTGTTTCAGATTTCAGAAAAGATTTAAAATCTTATTTAGATAGAGTTTCAAAAAATTTTGAAACTTT
AATCATCAACAGAGGAAAAGATTCTGGTATTGTTGTAATGTCTCTTGAAGAATACAATTCATTAATGGCGACAAACTATG
AATTATCTTCTCGTATCAACGAATCAAGACTTGATTCAGCCATTGAAAAATTAAAAAGTAATCAATCTTTCGAAAAAGAA
TTAATCGAAGAATAA
ATGTTAATAGCAAGTGTTTCAGATTTCAGAAAAGATTTAAAATCTTATTTAGATAGAGTTTCAAAAAATTTTGAAACTTT
AATCATCAACAGAGGAAAAGATTCTGGTATTGTTGTAATGTCTCTTGAAGAATACAATTCATTAATGGCGACAAACTATG
AATTATCTTCTCGTATCAACGAATCAAGACTTGATTCAGCCATTGAAAAATTAAAAAGTAATCAATCTTTCGAAAAAGAA
TTAATCGAAGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|