Detailed information of TA system TA211893

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 187341..187900
• Replicon: chromosome
• Accession: NZ_CP080463
• Organism: Vibrio cholerae strain ICDC-VC702

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D2YI11
• Locus tag: K1T74_RS15405
• Protein ID: WP_000578473.1
• Coordinates: 187341..187619 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9L991
• Locus tag: K1T74_RS15410
• Protein ID: WP_000381183.1
• Coordinates: 187616..187900 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K1T74_RS15370	182930..183484	+	555	WP_220106419.1	sugar O-acetyltransferase	-
K1T74_RS19855	183857..183919	+	63	Protein_192	DUF645 family protein	-
K1T74_RS19860	183909..184019	+	111	WP_223804330.1	Tfp pilus assembly protein	-
K1T74_RS15380	184178..184603	+	426	WP_220106420.1	GNAT family N-acetyltransferase	-
K1T74_RS15385	185083..185454	+	372	WP_220106505.1	DUF4144 domain-containing protein	-
K1T74_RS15390	185635..185871	-	237	WP_000772130.1	RNA-binding protein	-
K1T74_RS15395	186126..187196	+	1071	WP_220106421.1	hypothetical protein	-
K1T74_RS15400	187219..187311	+	93	WP_220106422.1	DUF3265 domain-containing protein	-
K1T74_RS15405	187341..187619	-	279	WP_000578473.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
K1T74_RS15410	187616..187900	-	285	WP_000381183.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
K1T74_RS15415	188016..188666	+	651	WP_220106423.1	DUF4875 domain-containing protein	-
K1T74_RS15420	188821..189132	+	312	WP_000623749.1	hypothetical protein	-
K1T74_RS19865	189228..189902	+	675	WP_258534315.1	SLATT domain-containing protein	-
K1T74_RS15430	190060..190584	+	525	WP_220106424.1	GNAT family protein	-
K1T74_RS15435	190758..190994	-	237	WP_000772130.1	RNA-binding protein	-
K1T74_RS15440	191246..191671	+	426	WP_220106425.1	GNAT family N-acetyltransferase	-
K1T74_RS15445	191858..192166	+	309	WP_220106426.1	hypothetical protein	-
K1T74_RS15450	192316..192804	+	489	WP_002051091.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	146834..233648	86814

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10868.59 Da
• Isoelectric Point: 4.6794

>T211893 WP_000578473.1 NZ_CP080463:c187619-187341 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIETKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Nucleotide

• Length: 279 bp

>T211893 NZ_CP106831:38419-38673 [Empedobacter falsenii]
ATGTTAATAGCAAGTGTTTCAGATTTCAGAAAAGATTTAAAATCTTATTTAGATAGAGTTTCAAAAAATTTTGAAACTTT
AATCATCAACAGAGGAAAAGATTCTGGTATTGTTGTAATGTCTCTTGAAGAATACAATTCATTAATGGCGACAAACTATG
AATTATCTTCTCGTATCAACGAATCAAGACTTGATTCAGCCATTGAAAAATTAAAAAGTAATCAATCTTTCGAAAAAGAA
TTAATCGAAGAATAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10901.25 Da
• Isoelectric Point: 8.0775

>AT211893 WP_000381183.1 NZ_CP080463:c187900-187616 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Nucleotide

• Length: 285 bp

>AT211893 NZ_CP106831:38674-38931 [Empedobacter falsenii]
ATGAAATACATATTCGTAGATGAATCTTGGGAAGATTATTTGTTTTGGCAAAAAACAGACAAAAAAAAAGTCAAACGAAT
CAATGATCTATTAAAAGACATCTCTAGAACACCTTTTACAGGAATAAGGAAGCCAGAGCCTTTAAAACATAAGTATTCGG
GGTTTTGGTCACGAAGAATAGATGATGAACATCGTTTAATATATAAATATGAAGACGGACAAATACTTATTGCTAAATGC
CGTTTTCATTATGATTAA

Structures

Toxin

• AlphaFold DB: D2YI11

Antitoxin

• AlphaFold DB: A0A067BL33