Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /DUF1778(antitoxin) |
| Location | 181087..182018 | Replicon | chromosome |
| Accession | NZ_CP080463 | ||
| Organism | Vibrio cholerae strain ICDC-VC702 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | Q9KM94 |
| Locus tag | K1T74_RS15360 | Protein ID | WP_000118351.1 |
| Coordinates | 181485..182018 (+) | Length | 178 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | K1T74_RS15355 | Protein ID | WP_012706060.1 |
| Coordinates | 181087..181488 (+) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K1T74_RS15320 | 176360..176821 | + | 462 | WP_142729373.1 | hypothetical protein | - |
| K1T74_RS15325 | 177143..177295 | + | 153 | WP_142542324.1 | DUF645 family protein | - |
| K1T74_RS15330 | 177561..177698 | + | 138 | WP_000757220.1 | YHYH domain-containing protein | - |
| K1T74_RS15335 | 177951..178568 | + | 618 | WP_142736388.1 | plasmid pRiA4b ORF-3 family protein | - |
| K1T74_RS15340 | 178711..179181 | + | 471 | WP_258534311.1 | dual specificity protein phosphatase family protein | - |
| K1T74_RS15345 | 179272..180174 | + | 903 | WP_001203707.1 | hypothetical protein | - |
| K1T74_RS19845 | 180250..180318 | + | 69 | Protein_185 | acetyltransferase | - |
| K1T74_RS15350 | 180331..180984 | + | 654 | WP_113612641.1 | hypothetical protein | - |
| K1T74_RS15355 | 181087..181488 | + | 402 | WP_012706060.1 | DUF1778 domain-containing protein | Antitoxin |
| K1T74_RS15360 | 181485..182018 | + | 534 | WP_000118351.1 | GNAT family N-acetyltransferase | Toxin |
| K1T74_RS19850 | 182028..182138 | + | 111 | WP_086010065.1 | DUF3265 domain-containing protein | - |
| K1T74_RS15365 | 182165..182776 | + | 612 | WP_113622232.1 | hypothetical protein | - |
| K1T74_RS15370 | 182930..183484 | + | 555 | WP_220106419.1 | sugar O-acetyltransferase | - |
| K1T74_RS19855 | 183857..183919 | + | 63 | Protein_192 | DUF645 family protein | - |
| K1T74_RS19860 | 183909..184019 | + | 111 | WP_223804330.1 | Tfp pilus assembly protein | - |
| K1T74_RS15380 | 184178..184603 | + | 426 | WP_220106420.1 | GNAT family N-acetyltransferase | - |
| K1T74_RS15385 | 185083..185454 | + | 372 | WP_220106505.1 | DUF4144 domain-containing protein | - |
| K1T74_RS15390 | 185635..185871 | - | 237 | WP_000772130.1 | RNA-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 146834..233648 | 86814 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 178 a.a. Molecular weight: 20171.46 Da Isoelectric Point: 9.1432
>T211892 WP_000118351.1 NZ_CP080463:181485-182018 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ
Download Length: 534 bp
>T211892 NZ_CP106826:c1644147-1643965 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA
Antitoxin
Download Length: 134 a.a. Molecular weight: 14855.25 Da Isoelectric Point: 7.7413
>AT211892 WP_012706060.1 NZ_CP080463:181087-181488 [Vibrio cholerae]
MRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVR
LMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK
MRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVR
LMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK
Download Length: 402 bp
>AT211892 NZ_CP106826:c1643863-1643462 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|