Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 154056..154554 Replicon chromosome
Accession NZ_CP080463
Organism Vibrio cholerae strain ICDC-VC702

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag K1T74_RS15150 Protein ID WP_000589156.1
Coordinates 154056..154322 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag K1T74_RS15155 Protein ID WP_000643598.1
Coordinates 154309..154554 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1T74_RS15120 149342..149878 + 537 WP_220106410.1 GNAT family protein -
K1T74_RS15125 150405..150905 + 501 WP_148530004.1 NAD(P)H-dependent oxidoreductase -
K1T74_RS15130 151161..151586 + 426 WP_108347903.1 hypothetical protein -
K1T74_RS15135 151934..152053 + 120 Protein_129 DUF645 family protein -
K1T74_RS19760 152043..152141 + 99 WP_230078617.1 Tfp pilus assembly protein -
K1T74_RS15140 152318..152905 + 588 WP_185842728.1 hypothetical protein -
K1T74_RS15145 153065..153874 + 810 WP_199357937.1 GIY-YIG nuclease family protein -
K1T74_RS15150 154056..154322 + 267 WP_000589156.1 BrnT family toxin Toxin
K1T74_RS15155 154309..154554 + 246 WP_000643598.1 hypothetical protein Antitoxin
K1T74_RS19765 154650..154793 + 144 WP_258534307.1 acetyltransferase -
K1T74_RS19770 154926..154981 + 56 Protein_136 DUF645 family protein -
K1T74_RS19775 154960..155055 + 96 WP_230965109.1 Tfp pilus assembly protein -
K1T74_RS15165 155231..155767 + 537 WP_149595946.1 nucleotidyltransferase family protein -
K1T74_RS15170 155911..156540 + 630 WP_001009012.1 type B-5 chloramphenicol O-acetyltransferase CatB9 -
K1T74_RS15175 156696..157232 + 537 WP_000469484.1 GNAT family protein -
K1T74_RS15180 157416..157979 + 564 WP_156844814.1 hypothetical protein -
K1T74_RS15185 157972..158487 + 516 WP_114806728.1 hypothetical protein -
K1T74_RS15190 158584..158745 + 162 WP_113625331.1 DUF3709 domain-containing protein -
K1T74_RS15195 158766..158987 + 222 WP_114710075.1 DUF3709 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 146834..233648 86814


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T211891 WP_000589156.1 NZ_CP080463:154056-154322 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T211891 NZ_CP106826:661467-661886 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT211891 WP_000643598.1 NZ_CP080463:154309-154554 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT211891 NZ_CP106826:661231-661467 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VMP7

Antitoxin

Source ID Structure
AlphaFold DB A0A271VME2

References