Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | /BrnT(toxin) |
Location | 154056..154554 | Replicon | chromosome |
Accession | NZ_CP080463 | ||
Organism | Vibrio cholerae strain ICDC-VC702 |
Toxin (Protein)
Gene name | - | Uniprot ID | Q9KMK7 |
Locus tag | K1T74_RS15150 | Protein ID | WP_000589156.1 |
Coordinates | 154056..154322 (+) | Length | 89 a.a. |
Antitoxin (Protein)
Gene name | - | Uniprot ID | Q9KMK6 |
Locus tag | K1T74_RS15155 | Protein ID | WP_000643598.1 |
Coordinates | 154309..154554 (+) | Length | 82 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K1T74_RS15120 | 149342..149878 | + | 537 | WP_220106410.1 | GNAT family protein | - |
K1T74_RS15125 | 150405..150905 | + | 501 | WP_148530004.1 | NAD(P)H-dependent oxidoreductase | - |
K1T74_RS15130 | 151161..151586 | + | 426 | WP_108347903.1 | hypothetical protein | - |
K1T74_RS15135 | 151934..152053 | + | 120 | Protein_129 | DUF645 family protein | - |
K1T74_RS19760 | 152043..152141 | + | 99 | WP_230078617.1 | Tfp pilus assembly protein | - |
K1T74_RS15140 | 152318..152905 | + | 588 | WP_185842728.1 | hypothetical protein | - |
K1T74_RS15145 | 153065..153874 | + | 810 | WP_199357937.1 | GIY-YIG nuclease family protein | - |
K1T74_RS15150 | 154056..154322 | + | 267 | WP_000589156.1 | BrnT family toxin | Toxin |
K1T74_RS15155 | 154309..154554 | + | 246 | WP_000643598.1 | hypothetical protein | Antitoxin |
K1T74_RS19765 | 154650..154793 | + | 144 | WP_258534307.1 | acetyltransferase | - |
K1T74_RS19770 | 154926..154981 | + | 56 | Protein_136 | DUF645 family protein | - |
K1T74_RS19775 | 154960..155055 | + | 96 | WP_230965109.1 | Tfp pilus assembly protein | - |
K1T74_RS15165 | 155231..155767 | + | 537 | WP_149595946.1 | nucleotidyltransferase family protein | - |
K1T74_RS15170 | 155911..156540 | + | 630 | WP_001009012.1 | type B-5 chloramphenicol O-acetyltransferase CatB9 | - |
K1T74_RS15175 | 156696..157232 | + | 537 | WP_000469484.1 | GNAT family protein | - |
K1T74_RS15180 | 157416..157979 | + | 564 | WP_156844814.1 | hypothetical protein | - |
K1T74_RS15185 | 157972..158487 | + | 516 | WP_114806728.1 | hypothetical protein | - |
K1T74_RS15190 | 158584..158745 | + | 162 | WP_113625331.1 | DUF3709 domain-containing protein | - |
K1T74_RS15195 | 158766..158987 | + | 222 | WP_114710075.1 | DUF3709 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Integron | - | - | 146834..233648 | 86814 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10092.34 Da Isoelectric Point: 7.3171
>T211891 WP_000589156.1 NZ_CP080463:154056-154322 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA
Download Length: 267 bp
>T211891 NZ_CP106826:661467-661886 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9478.77 Da Isoelectric Point: 6.4832
>AT211891 WP_000643598.1 NZ_CP080463:154309-154554 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R
Download Length: 246 bp
>AT211891 NZ_CP106826:661231-661467 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A271VMP7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A271VME2 |